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The map label for this gene is thrC

Identifier: 45656382

GI number: 45656382

Start: 560695

End: 562044

Strand: Direct

Name: thrC

Synonym: LIC10484

Alternate gene names: 45656382

Gene position: 560695-562044 (Clockwise)

Preceding gene: 45656381

Following gene: 45656383

Centisome position: 13.11

GC content: 39.78

Gene sequence:

>1350_bases
ATGATCTCTACTTTTACTCGATACAAAGCTGAATTTGAATGTATCAACGATTCCTGTAAAACCAGATATGATCTAAACGA
AATCATTTATGAATGTAAAAAGTGCGGAAGTCTTCTCCAAGTTTCCCACGATTTAGATGCGTTAAAATCTGTATCCGGAC
AGGAATGGAAGGATCTGTTTGATAGTAGATTTCGTTCTGTCAAGTTTCCCAATTCTTCCGGAATTTGGAACAAAAGAGAA
TGGGTTCTTCCTCATATCGAGGATAAGAACATTGTAACTTCAGGTGAAGGTCTTACTCATCTTTTTACTTCGGATCGATT
GACCGAAAGTCTTGGACTCGGAAGTTTTTATGTGAAACAGTGTGGGATCTCACACACTGGATCTTTTAAAGATTTAGGAA
TGACTGTTTTATTATCTCAAGTAAAACAGATGATTTCTTCTGGGGTTCCGATTCGTGCAGTGGCTTGTGCTAGTTCGGGA
GATACTTCGGCCGCTTTAGCATCTTACGCCGCAAAGGCGGGAATTCCTGCGATTATATTTTTACCTGCGGGTAAAGTGTC
TCAAGCGCAACTGATTCAACCAGTATCTAACGGTGCTAAGGTGATCGCACTTGATACTGACTTTGATGGTTGTATGAAAA
TCGTCAAAGAAGTAACTCGAGAAGCTGGAATTTATTTAGCAAACTCGATGAACTCTTTACGGATTGAAGGACAAAAAACG
ATTTCAGTGGAAATCACTCAACAGTTAGGGTGGAAGGTTCCGGATTGGATCGTAATTCCGGGTGGAAATTTAGGAAACGT
ATCTGCGTTAGGTGCTGGTTTCGAGATGATGTTTTCTTTGGGGCTAATAGATAAACTTCCGAGGATCGTTTTAGCACAAG
CGGAACACGCAAATCCTCTTTATCTTTCTTATTTAAAGAATTTTGAAAGTTTTGAACCGGTTTCTGCAAAAACGACTCTT
GCTTCTGCGATTCAAATTGGAAATCCGGTTTCGATTCAAAAGGCGATCAAAACTCTTAAAAAGTTCAATGGGGTTGTGGA
ACAGGCCAGCGAATCGGAGTTAGCCGATGCGGCCTCTAAAGCGGACTTATTCGGTTTATACAATGATCCTCATACGGGTG
TGGCTTTGGCGGCTTTGGAAAAGTTGATTCAAAAAGGAACCATTTCTAAAGGTGAGAGTGTAGTAGTCATTTCGACTGCT
CACGGATTGAAATTCACAGAGTTTAAGTTGAAATTCCACGGAGGTGAAATTCCTGGAACGGATTTTAAAATTGTAAATTC
AATTCATAAGGTAGAGCCTAAAGCGGATAAAGTAGTCGGTTTAATTCGGGATTTATTAGTTTCAAAATAA

Upstream 100 bases:

>100_bases
TGCAAGACTTGCCAAGTTAAAATCTCTTTTGGACGGGGGGTTGATTACTCAAGAAGAATTTGATACCAAAAAAAAGGACA
TTTTGAATTCTATCTAAAAT

Downstream 100 bases:

>100_bases
TTTGTTTTTGAAAATTGGGATTTAAACCGCGCACTAACCGAAAAATACAAGGTGGAGTTTTTGGTGCAAGGGCCTACTTT
AAATTTTCTTATCTTTCTGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MISTFTRYKAEFECINDSCKTRYDLNEIIYECKKCGSLLQVSHDLDALKSVSGQEWKDLFDSRFRSVKFPNSSGIWNKRE
WVLPHIEDKNIVTSGEGLTHLFTSDRLTESLGLGSFYVKQCGISHTGSFKDLGMTVLLSQVKQMISSGVPIRAVACASSG
DTSAALASYAAKAGIPAIIFLPAGKVSQAQLIQPVSNGAKVIALDTDFDGCMKIVKEVTREAGIYLANSMNSLRIEGQKT
ISVEITQQLGWKVPDWIVIPGGNLGNVSALGAGFEMMFSLGLIDKLPRIVLAQAEHANPLYLSYLKNFESFEPVSAKTTL
ASAIQIGNPVSIQKAIKTLKKFNGVVEQASESELADAASKADLFGLYNDPHTGVALAALEKLIQKGTISKGESVVVISTA
HGLKFTEFKLKFHGGEIPGTDFKIVNSIHKVEPKADKVVGLIRDLLVSK

Sequences:

>Translated_449_residues
MISTFTRYKAEFECINDSCKTRYDLNEIIYECKKCGSLLQVSHDLDALKSVSGQEWKDLFDSRFRSVKFPNSSGIWNKRE
WVLPHIEDKNIVTSGEGLTHLFTSDRLTESLGLGSFYVKQCGISHTGSFKDLGMTVLLSQVKQMISSGVPIRAVACASSG
DTSAALASYAAKAGIPAIIFLPAGKVSQAQLIQPVSNGAKVIALDTDFDGCMKIVKEVTREAGIYLANSMNSLRIEGQKT
ISVEITQQLGWKVPDWIVIPGGNLGNVSALGAGFEMMFSLGLIDKLPRIVLAQAEHANPLYLSYLKNFESFEPVSAKTTL
ASAIQIGNPVSIQKAIKTLKKFNGVVEQASESELADAASKADLFGLYNDPHTGVALAALEKLIQKGTISKGESVVVISTA
HGLKFTEFKLKFHGGEIPGTDFKIVNSIHKVEPKADKVVGLIRDLLVSK
>Mature_449_residues
MISTFTRYKAEFECINDSCKTRYDLNEIIYECKKCGSLLQVSHDLDALKSVSGQEWKDLFDSRFRSVKFPNSSGIWNKRE
WVLPHIEDKNIVTSGEGLTHLFTSDRLTESLGLGSFYVKQCGISHTGSFKDLGMTVLLSQVKQMISSGVPIRAVACASSG
DTSAALASYAAKAGIPAIIFLPAGKVSQAQLIQPVSNGAKVIALDTDFDGCMKIVKEVTREAGIYLANSMNSLRIEGQKT
ISVEITQQLGWKVPDWIVIPGGNLGNVSALGAGFEMMFSLGLIDKLPRIVLAQAEHANPLYLSYLKNFESFEPVSAKTTL
ASAIQIGNPVSIQKAIKTLKKFNGVVEQASESELADAASKADLFGLYNDPHTGVALAALEKLIQKGTISKGESVVVISTA
HGLKFTEFKLKFHGGEIPGTDFKIVNSIHKVEPKADKVVGLIRDLLVSK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=301, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48666; Mature: 48666

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTFTRYKAEFECINDSCKTRYDLNEIIYECKKCGSLLQVSHDLDALKSVSGQEWKDLF
CCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHH
DSRFRSVKFPNSSGIWNKREWVLPHIEDKNIVTSGEGLTHLFTSDRLTESLGLGSFYVKQ
HHHHHEEECCCCCCCCCCCCEECCCCCCCCEEECCCCCEEEHHHHHHHHHHCCCHHHHHH
CGISHTGSFKDLGMTVLLSQVKQMISSGVPIRAVACASSGDTSAALASYAAKAGIPAIIF
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
LPAGKVSQAQLIQPVSNGAKVIALDTDFDGCMKIVKEVTREAGIYLANSMNSLRIEGQKT
ECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEECCCCCEEECCCEE
ISVEITQQLGWKVPDWIVIPGGNLGNVSALGAGFEMMFSLGLIDKLPRIVLAQAEHANPL
EEEEEHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCH
YLSYLKNFESFEPVSAKTTLASAIQIGNPVSIQKAIKTLKKFNGVVEQASESELADAASK
HHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLFGLYNDPHTGVALAALEKLIQKGTISKGESVVVISTAHGLKFTEFKLKFHGGEIPGT
HHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEEEEECCCCCCC
DFKIVNSIHKVEPKADKVVGLIRDLLVSK
CHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISTFTRYKAEFECINDSCKTRYDLNEIIYECKKCGSLLQVSHDLDALKSVSGQEWKDLF
CCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHH
DSRFRSVKFPNSSGIWNKREWVLPHIEDKNIVTSGEGLTHLFTSDRLTESLGLGSFYVKQ
HHHHHEEECCCCCCCCCCCCEECCCCCCCCEEECCCCCEEEHHHHHHHHHHCCCHHHHHH
CGISHTGSFKDLGMTVLLSQVKQMISSGVPIRAVACASSGDTSAALASYAAKAGIPAIIF
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
LPAGKVSQAQLIQPVSNGAKVIALDTDFDGCMKIVKEVTREAGIYLANSMNSLRIEGQKT
ECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEECCCCCEEECCCEE
ISVEITQQLGWKVPDWIVIPGGNLGNVSALGAGFEMMFSLGLIDKLPRIVLAQAEHANPL
EEEEEHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCH
YLSYLKNFESFEPVSAKTTLASAIQIGNPVSIQKAIKTLKKFNGVVEQASESELADAASK
HHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLFGLYNDPHTGVALAALEKLIQKGTISKGESVVVISTAHGLKFTEFKLKFHGGEIPGT
HHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEEEEEECCCCCCC
DFKIVNSIHKVEPKADKVVGLIRDLLVSK
CHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]