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The map label for this gene is tmk

Identifier: 45358597

GI number: 45358597

Start: 1028504

End: 1029103

Strand: Direct

Name: tmk

Synonym: MMP1034

Alternate gene names: 45358597

Gene position: 1028504-1029103 (Clockwise)

Preceding gene: 45358596

Following gene: 45358598

Centisome position: 61.92

GC content: 30.83

Gene sequence:

>600_bases
ATGAACAAATTCATCGTTTTTGAAGGAATTGACGGCTGTGGAAAAACTACTCAGGCAAAACTCGTAGCTGAAAAATTAAA
TGCAAATTTTACATTTGAACCAACTGACGGAAAAATTGGAAAATCTATTAGAGAAATTTTAGCAGGTTCTAAATGCAATA
AAGAAACTCTCGCTCTCCTTTTTGCAGCAGACCGTGTTGAACACGTTTCAAAAATCGAAGAAGATTTGAAAAATGCACAT
GTTGTTTCAGACCGTTATGTATACTCTTCGATAGTTTACCAGATGACACAAGGAATTCCAAAAGATTTTATATACAAGAT
TAACGATTATGCAAAAATTCCAGATCTTGTGGTTTTACTCGATGTGGATTTAAATGAAGCTTTAAAAAGAATGGAGTCCA
GAGAAAAGGAAATATTTGAAAAACTGGAATTTCAGAAAAAAATAAAAGAAGGATATTACAACCTTATAAATTCAGAGAAT
GGAAAATTCATGCCAAAATATGGATTTATTGTAATTGATACAACTTCAAAACCAATAGATCAGGTTTTTAACGAAATTTT
AAACGCGATTGTCGATAAAATTCCAGATATTATACAATAA

Upstream 100 bases:

>100_bases
TTACGGAACATGGAGCATAAAAGAAGAAATAATGAGATTAAAATTATCATACTACAATAAATTAAGACAAAAACACTAAT
TATCTCTTTTTGGTAATATT

Downstream 100 bases:

>100_bases
ACTATATATTGTTCTTAGCAAATAGATTATTTAGTGCACTATATAAATAATCTAATCTTTAAAGGTGTATCATGGACTTA
GGTTATATAACAATTATAAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MNKFIVFEGIDGCGKTTQAKLVAEKLNANFTFEPTDGKIGKSIREILAGSKCNKETLALLFAADRVEHVSKIEEDLKNAH
VVSDRYVYSSIVYQMTQGIPKDFIYKINDYAKIPDLVVLLDVDLNEALKRMESREKEIFEKLEFQKKIKEGYYNLINSEN
GKFMPKYGFIVIDTTSKPIDQVFNEILNAIVDKIPDIIQ

Sequences:

>Translated_199_residues
MNKFIVFEGIDGCGKTTQAKLVAEKLNANFTFEPTDGKIGKSIREILAGSKCNKETLALLFAADRVEHVSKIEEDLKNAH
VVSDRYVYSSIVYQMTQGIPKDFIYKINDYAKIPDLVVLLDVDLNEALKRMESREKEIFEKLEFQKKIKEGYYNLINSEN
GKFMPKYGFIVIDTTSKPIDQVFNEILNAIVDKIPDIIQ
>Mature_199_residues
MNKFIVFEGIDGCGKTTQAKLVAEKLNANFTFEPTDGKIGKSIREILAGSKCNKETLALLFAADRVEHVSKIEEDLKNAH
VVSDRYVYSSIVYQMTQGIPKDFIYKINDYAKIPDLVVLLDVDLNEALKRMESREKEIFEKLEFQKKIKEGYYNLINSEN
GKFMPKYGFIVIDTTSKPIDQVFNEILNAIVDKIPDIIQ

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Caenorhabditis elegans, GI17535647, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322517, Length=193, Percent_Identity=33.6787564766839, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573735, Length=172, Percent_Identity=32.5581395348837, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METMP (Q6LYF7)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988154.1
- ProteinModelPortal:   Q6LYF7
- GeneID:   2761844
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP1034
- NMPDR:   fig|267377.1.peg.1034
- HOGENOM:   HBG626009
- OMA:   FTFEPTD
- ProtClustDB:   PRK13975
- BioCyc:   MMAR267377:MMP1034-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22724; Mature: 22724

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFIVFEGIDGCGKTTQAKLVAEKLNANFTFEPTDGKIGKSIREILAGSKCNKETLALL
CCCEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHH
FAADRVEHVSKIEEDLKNAHVVSDRYVYSSIVYQMTQGIPKDFIYKINDYAKIPDLVVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEE
DVDLNEALKRMESREKEIFEKLEFQKKIKEGYYNLINSENGKFMPKYGFIVIDTTSKPID
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
QVFNEILNAIVDKIPDIIQ
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKFIVFEGIDGCGKTTQAKLVAEKLNANFTFEPTDGKIGKSIREILAGSKCNKETLALL
CCCEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHH
FAADRVEHVSKIEEDLKNAHVVSDRYVYSSIVYQMTQGIPKDFIYKINDYAKIPDLVVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEE
DVDLNEALKRMESREKEIFEKLEFQKKIKEGYYNLINSENGKFMPKYGFIVIDTTSKPID
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
QVFNEILNAIVDKIPDIIQ
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA