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The map label for this gene is guaA [H]

Identifier: 45358457

GI number: 45358457

Start: 887183

End: 888115

Strand: Direct

Name: guaA [H]

Synonym: MMP0894

Alternate gene names: 45358457

Gene position: 887183-888115 (Clockwise)

Preceding gene: 45358456

Following gene: 45358458

Centisome position: 53.41

GC content: 37.41

Gene sequence:

>933_bases
ATGTTCAAGACCGAACCGTTTATAGAAGAATCCATTGAAGAAATAAGAAAGCAGATTAATAATAGAAAAACAATCATTGC
GCTGAGCGGTGGAGTTGACAGTGCAGTTGCTGCAGTTCTTACCGATAGGGCAGTTGGAGATAAATTACTTGCAGTTTACG
TTGATACCGGATTGATGAGAAAAAACGAGTCTGAAGAAATCTGGAAAATTTTTAAAGAACAGATGGGACTTAATTTAAAA
ATTGTCGAAGCAAAAGACATATTTTTAAAGGAACTTGAAGGAGTAATTGATCCGGAAGAAAAAAGAAAGATAATTGGAAG
GCTCTTTATCGAAGTATTTGAAAAAGTTGCAGAAGAACAGGGTGAAGAAGTACTCGTTCAGGGAACAATTGCACCAGACT
GGATTGAAAGTGAAGGACAGATTAAAACACACCACAATATTGCATTACCTGGCGGAATGGTTTTAGATGTTGTTGAACCG
TTAAGGGAACTCTATAAAGACGAAGTTAGACTTTTAGCAGTTGCACTCGGGTTACCTGACCAGATTGCACACAGACAGCC
TTTCCCTGGACCCGGACTTGCAGTTAGAATTTTGGGCGAAATTACAGATGAAAAATTAGCAATCTGTAAAGAAGCAAACT
TCATTGTTTCAGAAGAAATTGAAAAAACCGAACTTAAAAACGAACTCTGGCAGTACTTTGCAGCAGTGCTCGATACAAAA
GCAACTGGTGTTAAAGGCGACATTAGAGATTACAACTGGGTTGTTGCACTTAGATTTGTAAGCTCACTTGATGCAATGAC
TGCACACACCCCTGAAATTCCATTTGATCTTATAAAAAAAATCAGCAAAAGAATAACTTCAGAAATTCCAAACGTTACAA
GAGTAGTTCTTGACGTAACTGATAAACCACCAGCAACAATTGAATTTGAATAA

Upstream 100 bases:

>100_bases
CACCCCGAATTTAAATCAAGACCAAACAAACCTCACCCATTATTCCATGGATTGGTAAAAGCTTCGATTGAAAAATAATT
AATTATTTGGAGGAATATCA

Downstream 100 bases:

>100_bases
TTCTTTAAAATATCTCTTTTTTAAATTAAATTCTCTACCTACACAATAGCTATTTATTTTCAAACTTCATTATTCATTAT
ATCAAAAGATTTGGACTGTT

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MFKTEPFIEESIEEIRKQINNRKTIIALSGGVDSAVAAVLTDRAVGDKLLAVYVDTGLMRKNESEEIWKIFKEQMGLNLK
IVEAKDIFLKELEGVIDPEEKRKIIGRLFIEVFEKVAEEQGEEVLVQGTIAPDWIESEGQIKTHHNIALPGGMVLDVVEP
LRELYKDEVRLLAVALGLPDQIAHRQPFPGPGLAVRILGEITDEKLAICKEANFIVSEEIEKTELKNELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVSSLDAMTAHTPEIPFDLIKKISKRITSEIPNVTRVVLDVTDKPPATIEFE

Sequences:

>Translated_310_residues
MFKTEPFIEESIEEIRKQINNRKTIIALSGGVDSAVAAVLTDRAVGDKLLAVYVDTGLMRKNESEEIWKIFKEQMGLNLK
IVEAKDIFLKELEGVIDPEEKRKIIGRLFIEVFEKVAEEQGEEVLVQGTIAPDWIESEGQIKTHHNIALPGGMVLDVVEP
LRELYKDEVRLLAVALGLPDQIAHRQPFPGPGLAVRILGEITDEKLAICKEANFIVSEEIEKTELKNELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVSSLDAMTAHTPEIPFDLIKKISKRITSEIPNVTRVVLDVTDKPPATIEFE
>Mature_310_residues
MFKTEPFIEESIEEIRKQINNRKTIIALSGGVDSAVAAVLTDRAVGDKLLAVYVDTGLMRKNESEEIWKIFKEQMGLNLK
IVEAKDIFLKELEGVIDPEEKRKIIGRLFIEVFEKVAEEQGEEVLVQGTIAPDWIESEGQIKTHHNIALPGGMVLDVVEP
LRELYKDEVRLLAVALGLPDQIAHRQPFPGPGLAVRILGEITDEKLAICKEANFIVSEEIEKTELKNELWQYFAAVLDTK
ATGVKGDIRDYNWVVALRFVSSLDAMTAHTPEIPFDLIKKISKRITSEIPNVTRVVLDVTDKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=316, Percent_Identity=34.8101265822785, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1788854, Length=312, Percent_Identity=46.7948717948718, Blast_Score=288, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=371, Percent_Identity=31.8059299191375, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI133901714, Length=371, Percent_Identity=31.8059299191375, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71992717, Length=371, Percent_Identity=31.8059299191375, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323873, Length=320, Percent_Identity=46.875, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI281365319, Length=307, Percent_Identity=36.8078175895765, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 34857; Mature: 34857

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTEPFIEESIEEIRKQINNRKTIIALSGGVDSAVAAVLTDRAVGDKLLAVYVDTGLMR
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCHHHEEEEECCHHHC
KNESEEIWKIFKEQMGLNLKIVEAKDIFLKELEGVIDPEEKRKIIGRLFIEVFEKVAEEQ
CCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
GEEVLVQGTIAPDWIESEGQIKTHHNIALPGGMVLDVVEPLRELYKDEVRLLAVALGLPD
CCEEEEECCCCCCHHCCCCCEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QIAHRQPFPGPGLAVRILGEITDEKLAICKEANFIVSEEIEKTELKNELWQYFAAVLDTK
HHHCCCCCCCCCCEEHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ATGVKGDIRDYNWVVALRFVSSLDAMTAHTPEIPFDLIKKISKRITSEIPNVTRVVLDVT
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKPPATIEFE
CCCCCEEECC
>Mature Secondary Structure
MFKTEPFIEESIEEIRKQINNRKTIIALSGGVDSAVAAVLTDRAVGDKLLAVYVDTGLMR
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCHHHEEEEECCHHHC
KNESEEIWKIFKEQMGLNLKIVEAKDIFLKELEGVIDPEEKRKIIGRLFIEVFEKVAEEQ
CCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
GEEVLVQGTIAPDWIESEGQIKTHHNIALPGGMVLDVVEPLRELYKDEVRLLAVALGLPD
CCEEEEECCCCCCHHCCCCCEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QIAHRQPFPGPGLAVRILGEITDEKLAICKEANFIVSEEIEKTELKNELWQYFAAVLDTK
HHHCCCCCCCCCCEEHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ATGVKGDIRDYNWVVALRFVSSLDAMTAHTPEIPFDLIKKISKRITSEIPNVTRVVLDVT
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEC
DKPPATIEFE
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA