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The map label for this gene is pyrG

Identifier: 45358456

GI number: 45358456

Start: 885559

End: 887160

Strand: Direct

Name: pyrG

Synonym: MMP0893

Alternate gene names: 45358456

Gene position: 885559-887160 (Clockwise)

Preceding gene: 45358454

Following gene: 45358457

Centisome position: 53.31

GC content: 34.77

Gene sequence:

>1602_bases
ATGAAATATATATTTGTTACAGGCGGTGTAGTGTCTTCTTTAGGTAAAGGGATAACTTCATCATCTCTTGGAAGACTTCT
CAAAGCCAGGGGTTTGAACGTAAATATGATTAAAATCGACCCTTATTTACAGATCGATGCAGGTACGATGTCCCCATTTG
AACATGGTGAAGTTTTCGTAACTGATGATGGCGGAGAAACTGATCTTGACCTTGGAAATTACGAAAGATTTGTAGATATT
GGATTGAAAGCTGACAACAATATTACAACAGGTAAAATTTACTGGAGCGTTCTTTCAAAAGAAAGAAAAGGAGATTATCT
TGGAAAAACGGTTCAGGTAATTCCGCACATTACAAACGAGATAAAAGATAGAATCAAAAATCTTGGAAAAGAATCCGACA
TTACAATTATTGAAATTGGTGGAACTGTTGGAGATATCGAAAGTTTACCTTTTTTAGAAGCAATTAGGCAATTTAAAAAA
GATGTTGGAAAGGAAAATGTTCTCTATATTCACGTTTCACTTCTCCCATATATTAGAAGTGCAGGCGAATTAAAGACAAA
ACCAACACAACACTCGGTAAAAGAATTGAAAGGAATTGGAATTCAGCCAGATATATTGGTTTGTAGATCAGAAATTCCGA
TAAGTGAAAAAATAAAAGACAAACTTGCGCTCTTTTGCGATGTTGAAAAAGAAGCAGTAATTGAATGTAAAGACGCAAGA
ACAATTTACGAAGTTCCACTAAATCTTGAAAAAGAAGGACTTGGAAAATTAGTTACTGAAAAACTTAATTTAAGAGATTC
AACTCCAGATTTAACTGAATGGAGAGCTATTGTTGACAGAATCATAAACCCGATGAATGAAATCACAATTGGAATCGTTG
GAAAATACATCGAATTAAAAGATTCTTACATGAGTATAATGGAAGCTTTAGGCCATGCAGGTGCTAAAAACGATACTAAA
GTAAATATTGCATGGATTAATTCAGAAGAACTAGAAACCAAAAATTATGAAGAAATCCTCAACAAAATGGTTGACGATGA
AAAATTACATGGTATTTTGGTTCCCGGCGGTTTTGGAGATCGAGGAATCGATGGAAAAGTAAATGCCGTACGATATGCAA
GAGAAAAAAATATTCCGTTTTTAGGAATATGTCTTGGAATGCAGTGTGCAGTAATTGAATTTGCAAGACACGTATGTGGT
TTAAATGCCAATTCAACAGAATTTGACGAAGAAACTGAACATCCTGTAATTGATTACATTCCAGAACAGCGTGAAGTAAC
TGAAAAAGGGGGAACCATGAGACTTGGTGCATACCCTGCAGTTTTAACAGAAAATTCGCTTGCAAGTGAATTATACGGTT
CAATAAATGCATCTGAAAGACACAGACACCGATATGAAGTAAATCCAGAATACCATGAAATATTGAAGAAAAACGGGTTA
ATAATTTCGGGAATGTCACCTGACGGAAAACTTGCAGAATTCATAGAACTTGAAAATCACAAGTACTTTATTGCAACACA
AGCACACCCCGAATTTAAATCAAGACCAAACAAACCTCACCCATTATTCCATGGATTGGTAAAAGCTTCGATTGAAAAAT
AA

Upstream 100 bases:

>100_bases
TCTAAAATTTTGTTTTCAAAAAATCGGGAAACATTTATATTTGATTGAATAATATTTCTAAAATTATTATTTTGATTTTA
CTATTTATCGAGGGATTCTG

Downstream 100 bases:

>100_bases
TTAATTATTTGGAGGAATATCAATGTTCAAGACCGAACCGTTTATAGAAGAATCCATTGAAGAAATAAGAAAGCAGATTA
ATAATAGAAAAACAATCATT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFVTDDGGETDLDLGNYERFVDI
GLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNEIKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDAR
TIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELKDSYMSIMEALGHAGAKNDTK
VNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGDRGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCG
LNANSTEFDEETEHPVIDYIPEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGL
IISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK

Sequences:

>Translated_533_residues
MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFVTDDGGETDLDLGNYERFVDI
GLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNEIKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDAR
TIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELKDSYMSIMEALGHAGAKNDTK
VNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGDRGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCG
LNANSTEFDEETEHPVIDYIPEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGL
IISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK
>Mature_533_residues
MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFVTDDGGETDLDLGNYERFVDI
GLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNEIKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKK
DVGKENVLYIHVSLLPYIRSAGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDAR
TIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELKDSYMSIMEALGHAGAKNDTK
VNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGDRGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCG
LNANSTEFDEETEHPVIDYIPEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGL
IISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=552, Percent_Identity=50.5434782608696, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=50.2722323049002, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=50.2722323049002, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=50.2722323049002, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=53.4195933456562, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25148299, Length=606, Percent_Identity=41.2541254125413, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=47.7718360071301, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319432, Length=559, Percent_Identity=48.1216457960644, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24664469, Length=554, Percent_Identity=49.0974729241877, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI21357815, Length=498, Percent_Identity=46.9879518072289, Blast_Score=444, Evalue=1e-125,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_METMP (Q6LYU4)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988013.1
- HSSP:   P17812
- ProteinModelPortal:   Q6LYU4
- SMR:   Q6LYU4
- GeneID:   2761197
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0893
- NMPDR:   fig|267377.1.peg.893
- HOGENOM:   HBG597806
- OMA:   DNINSWI
- ProtClustDB:   PRK05380
- BioCyc:   MMAR267377:MMP0893-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59547; Mature: 59547

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 384-384 ACT_SITE 509-509 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFVDIGLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHEEEHHHHHCCCHHCHHHHHHHHHHHH
IKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRS
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHC
AGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDAR
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHEEEECCCHHHEEEECCCC
TIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELK
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHEEEEEEEHHHHHH
DSYMSIMEALGHAGAKNDTKVNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGD
HHHHHHHHHHHCCCCCCCCEEEEEEECCHHCCCCCHHHHHHHHCCCCCCCEEEECCCCCC
RGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCGLNANSTEFDEETEHPVIDYI
CCCCCCCHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCC
PEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGL
CCHHHHHHCCCEEEECCCCCEEECCHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHCCE
IISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK
EEECCCCCCHHHHHEEECCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKYIFVTGGVVSSLGKGITSSSLGRLLKARGLNVNMIKIDPYLQIDAGTMSPFEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFVDIGLKADNNITTGKIYWSVLSKERKGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHEEEHHHHHCCCHHCHHHHHHHHHHHH
IKDRIKNLGKESDITIIEIGGTVGDIESLPFLEAIRQFKKDVGKENVLYIHVSLLPYIRS
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHC
AGELKTKPTQHSVKELKGIGIQPDILVCRSEIPISEKIKDKLALFCDVEKEAVIECKDAR
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHEEEECCCHHHEEEECCCC
TIYEVPLNLEKEGLGKLVTEKLNLRDSTPDLTEWRAIVDRIINPMNEITIGIVGKYIELK
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHEEEEEEEHHHHHH
DSYMSIMEALGHAGAKNDTKVNIAWINSEELETKNYEEILNKMVDDEKLHGILVPGGFGD
HHHHHHHHHHHCCCCCCCCEEEEEEECCHHCCCCCHHHHHHHHCCCCCCCEEEECCCCCC
RGIDGKVNAVRYAREKNIPFLGICLGMQCAVIEFARHVCGLNANSTEFDEETEHPVIDYI
CCCCCCCHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCC
PEQREVTEKGGTMRLGAYPAVLTENSLASELYGSINASERHRHRYEVNPEYHEILKKNGL
CCHHHHHHCCCEEEECCCCCEEECCHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHCCE
IISGMSPDGKLAEFIELENHKYFIATQAHPEFKSRPNKPHPLFHGLVKASIEK
EEECCCCCCHHHHHEEECCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA