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The map label for this gene is rncS

Identifier: 42523419

GI number: 42523419

Start: 1854247

End: 1854951

Strand: Direct

Name: rncS

Synonym: Bd1941

Alternate gene names: 42523419

Gene position: 1854247-1854951 (Clockwise)

Preceding gene: 42523418

Following gene: 42523420

Centisome position: 49.02

GC content: 50.5

Gene sequence:

>705_bases
ATGATCGATCAGGGGCGAAAGAGTCTGGAAGAGCGTGTAGGACATCAATTTAAAAACCCGGCACTGCTGGAAAGAGCGTT
GACCCACAAGAGTTTTGCCAACGAGCTGAGAAACACCGTTGAGCACAATGAAAAGCTGGAATTTTTGGGTGACGCTGTTT
TGGATCTGGTGGTGGGAGAGTTTTTGTATGAAAAATTCCCGACCGACACCGAAGGTGGTTTGTCAAAGAAACGAGCCAGT
ATTGTTAATGAAGAGGTTCTGTCCGAACTGGCATTGGAAATGGGTTTAAATAAACTCATGCAACTGGGAAAGGGTGAAGC
CCTGACCGGGGGCGCGCAGAAGCCGCGCCTGATAGCCTCTTCGTTTGAAGCCATTGTCGGGGCGTTGTACCTGGATGGTG
GGTTTGAAGTGGCTCGCAGCTTTATTCGCCAGGAGTTTGTTCCTTTGGCGGACCGGGTCTGCGGGCATGAGGACTTCGAG
CGGGATTATAAAACCCGTCTGCAGGAACTGGTGCAGAAGTCCTCGAAAGAAACGCCACGCTATGAAGTGCTGGCGGAAGA
AGGACCTCCGCATGATCGTGAGTTCCTGGTTTGTGTAAAAGTAAAAGAAGATGTCTGGGCTCAAGGGCGGGGCCGCAGTA
AGAAAAACGCCGAACAAATGGCGGCAAAGAATGCCCTTGAGATGAAGTACAAGGAGACGAATTAA

Upstream 100 bases:

>100_bases
TGGATCACTGGGCAGGGCAGGAAGTTGATGTGAAAGTCACAGGCTATGATCATTCCAACAAACAACACATGGAAGGTCAT
CTGATCGGCGAGGTGCTCTC

Downstream 100 bases:

>100_bases
GATGAGTTACAAAGCTGGATTTTTAGGTCTGATCGGACAGCCGAACGCGGGGAAGAGCACATTGATGAACTTCCTTGTGG
ACGAAAAGGTCTCTATCGTC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MIDQGRKSLEERVGHQFKNPALLERALTHKSFANELRNTVEHNEKLEFLGDAVLDLVVGEFLYEKFPTDTEGGLSKKRAS
IVNEEVLSELALEMGLNKLMQLGKGEALTGGAQKPRLIASSFEAIVGALYLDGGFEVARSFIRQEFVPLADRVCGHEDFE
RDYKTRLQELVQKSSKETPRYEVLAEEGPPHDREFLVCVKVKEDVWAQGRGRSKKNAEQMAAKNALEMKYKETN

Sequences:

>Translated_234_residues
MIDQGRKSLEERVGHQFKNPALLERALTHKSFANELRNTVEHNEKLEFLGDAVLDLVVGEFLYEKFPTDTEGGLSKKRAS
IVNEEVLSELALEMGLNKLMQLGKGEALTGGAQKPRLIASSFEAIVGALYLDGGFEVARSFIRQEFVPLADRVCGHEDFE
RDYKTRLQELVQKSSKETPRYEVLAEEGPPHDREFLVCVKVKEDVWAQGRGRSKKNAEQMAAKNALEMKYKETN
>Mature_234_residues
MIDQGRKSLEERVGHQFKNPALLERALTHKSFANELRNTVEHNEKLEFLGDAVLDLVVGEFLYEKFPTDTEGGLSKKRAS
IVNEEVLSELALEMGLNKLMQLGKGEALTGGAQKPRLIASSFEAIVGALYLDGGFEVARSFIRQEFVPLADRVCGHEDFE
RDYKTRLQELVQKSSKETPRYEVLAEEGPPHDREFLVCVKVKEDVWAQGRGRSKKNAEQMAAKNALEMKYKETN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=31.304347826087, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=31.304347826087, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788920, Length=209, Percent_Identity=35.4066985645933, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=229, Percent_Identity=34.061135371179, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=229, Percent_Identity=34.061135371179, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137682, Length=225, Percent_Identity=32, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_BDEBA (Q6MLR5)

Other databases:

- EMBL:   BX842651
- RefSeq:   NP_968799.1
- ProteinModelPortal:   Q6MLR5
- SMR:   Q6MLR5
- GeneID:   2734678
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1941
- NMPDR:   fig|264462.1.peg.1770
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q6MLR5
- BioCyc:   BBAC264462:BD1941-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26428; Mature: 26428

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQGRKSLEERVGHQFKNPALLERALTHKSFANELRNTVEHNEKLEFLGDAVLDLVVGE
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLYEKFPTDTEGGLSKKRASIVNEEVLSELALEMGLNKLMQLGKGEALTGGAQKPRLIAS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SFEAIVGALYLDGGFEVARSFIRQEFVPLADRVCGHEDFERDYKTRLQELVQKSSKETPR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
YEVLAEEGPPHDREFLVCVKVKEDVWAQGRGRSKKNAEQMAAKNALEMKYKETN
EEEEECCCCCCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIDQGRKSLEERVGHQFKNPALLERALTHKSFANELRNTVEHNEKLEFLGDAVLDLVVGE
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLYEKFPTDTEGGLSKKRASIVNEEVLSELALEMGLNKLMQLGKGEALTGGAQKPRLIAS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SFEAIVGALYLDGGFEVARSFIRQEFVPLADRVCGHEDFERDYKTRLQELVQKSSKETPR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
YEVLAEEGPPHDREFLVCVKVKEDVWAQGRGRSKKNAEQMAAKNALEMKYKETN
EEEEECCCCCCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA