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The map label for this gene is neuC [H]

Identifier: 42523178

GI number: 42523178

Start: 1617215

End: 1618387

Strand: Direct

Name: neuC [H]

Synonym: Bd1680

Alternate gene names: 42523178

Gene position: 1617215-1618387 (Clockwise)

Preceding gene: 42523177

Following gene: 42523179

Centisome position: 42.75

GC content: 44.33

Gene sequence:

>1173_bases
GTGAAAAGACGAATTTGTGTGTTAAGTGGAACGAGGGCAGACTACGGCCTGCTCTACTGGCTTATGAAAGAGCTTCAGAC
TTACTCGTCAGTAGACCTGCAAATCATTGCGACCGGTATGCACTTAAGTCCTGAATTTGGTATGACATATAAATTCATCG
AGGCTGACGGTTTTCTAATTAATGAAAAAGTTGAGATGCTACTGTCGGGAGATTCTGTAACAGCCCTGTGTAAATCAATG
GGTTTAGGGGTCATGGGTATTTCGGAGGCATTGGCAAGACTTTCCCCGGACCTGCTAGTTGTTCTGGGTGATAGATTTGA
AGCCCTTGCTGGAGCTCAGGCTGCGATGATTCACCGTATACCGATTGCTCATCTTCATGGCGGTGAAGCTACCGAAGGCT
TGATTGATGAAGCCATTCGGCATTCGATCACTAAGATGTCGCACTTGCATTTTGTTGCAGCCGAAGCATATCGAAATAAA
GTTATTCAGTTGGGGGAGTCTCCAGATAGGGTTTTCAACTTTGGAGCTACGGGAATCGACAACATTAAGAGACTTCCTCT
TTTTAATCGTGAGGAAGTGGAAGAAAGGATTCCTGTGCTGAAAGGTGCAAAGGGGCCTGTTTTTCTTGTCACTTATCACC
CAGTGACACTTTTAAATAGTTCTCCAGAGCAGGCGATGGCTGATTTGCTGTCAGCGATCGAGGAGTTCTCGGATGCTTGT
GTAATATTGACGAAATCAAACGCTGATACAGCAGGCCGCGTAATTAATGAAATGATTGATCAGTTTTGTCTGAAGCATCC
TGAAAGAGCAATGTCTAGTGTTTCCCTGGGGCAGAAGCTGTACCTGAGTGTGATGTCCATAGCTAATGTGGTCGTTGGAA
ACTCATCGAGTGGTATTATTGAGGCTCCGGCTATGAATATTCCAACAGTTAACATTGGTCCTCGTCAGCAGGGGCGAGCC
AAAGCCCCATCCGTTTTGGACTGTAACGAGACAAAATCTGAGATTGTAAGTGGTATTCAAACCGTTCTCGAAAATAGCTT
TATGGCATCCCGCAAAGATAAACATGTATATGGCGATGGAAATACGGCTGTTAAGGTTGCTGAAGTCCTTGCCTCTTATG
ATCTTGACGGAATCATTTTCAAAAAATTTTATAGTATTGATGGCGTGAAATGA

Upstream 100 bases:

>100_bases
GCACGAATGCTGTCTGATCGGCTCGTAAACATTCCAAGCAGTGTAAGGCTTCCTCGAGGTTAATGGACCTTGGTGAGTTG
TTGATTTTACGGGGGATTTG

Downstream 100 bases:

>100_bases
AGATTGCGTTTATTGGCTGCGTGGATTTTAGTGAAGCTATGCTCAGAACGGTACTTAACGTTCCAAAAGCTGAAGTTTGC
TGTATTATCACCCGTAAGGC

Product: putative UDP-N-acetylglucosamine-2-epimerase NeuC

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKRRICVLSGTRADYGLLYWLMKELQTYSSVDLQIIATGMHLSPEFGMTYKFIEADGFLINEKVEMLLSGDSVTALCKSM
GLGVMGISEALARLSPDLLVVLGDRFEALAGAQAAMIHRIPIAHLHGGEATEGLIDEAIRHSITKMSHLHFVAAEAYRNK
VIQLGESPDRVFNFGATGIDNIKRLPLFNREEVEERIPVLKGAKGPVFLVTYHPVTLLNSSPEQAMADLLSAIEEFSDAC
VILTKSNADTAGRVINEMIDQFCLKHPERAMSSVSLGQKLYLSVMSIANVVVGNSSSGIIEAPAMNIPTVNIGPRQQGRA
KAPSVLDCNETKSEIVSGIQTVLENSFMASRKDKHVYGDGNTAVKVAEVLASYDLDGIIFKKFYSIDGVK

Sequences:

>Translated_390_residues
MKRRICVLSGTRADYGLLYWLMKELQTYSSVDLQIIATGMHLSPEFGMTYKFIEADGFLINEKVEMLLSGDSVTALCKSM
GLGVMGISEALARLSPDLLVVLGDRFEALAGAQAAMIHRIPIAHLHGGEATEGLIDEAIRHSITKMSHLHFVAAEAYRNK
VIQLGESPDRVFNFGATGIDNIKRLPLFNREEVEERIPVLKGAKGPVFLVTYHPVTLLNSSPEQAMADLLSAIEEFSDAC
VILTKSNADTAGRVINEMIDQFCLKHPERAMSSVSLGQKLYLSVMSIANVVVGNSSSGIIEAPAMNIPTVNIGPRQQGRA
KAPSVLDCNETKSEIVSGIQTVLENSFMASRKDKHVYGDGNTAVKVAEVLASYDLDGIIFKKFYSIDGVK
>Mature_390_residues
MKRRICVLSGTRADYGLLYWLMKELQTYSSVDLQIIATGMHLSPEFGMTYKFIEADGFLINEKVEMLLSGDSVTALCKSM
GLGVMGISEALARLSPDLLVVLGDRFEALAGAQAAMIHRIPIAHLHGGEATEGLIDEAIRHSITKMSHLHFVAAEAYRNK
VIQLGESPDRVFNFGATGIDNIKRLPLFNREEVEERIPVLKGAKGPVFLVTYHPVTLLNSSPEQAMADLLSAIEEFSDAC
VILTKSNADTAGRVINEMIDQFCLKHPERAMSSVSLGQKLYLSVMSIANVVVGNSSSGIIEAPAMNIPTVNIGPRQQGRA
KAPSVLDCNETKSEIVSGIQTVLENSFMASRKDKHVYGDGNTAVKVAEVLASYDLDGIIFKKFYSIDGVK

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=388, Percent_Identity=30.9278350515464, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI190014632, Length=388, Percent_Identity=30.9278350515464, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4885285, Length=388, Percent_Identity=30.9278350515464, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI298566325, Length=354, Percent_Identity=30.225988700565, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI298566315, Length=131, Percent_Identity=37.4045801526718, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42480; Mature: 42480

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRICVLSGTRADYGLLYWLMKELQTYSSVDLQIIATGMHLSPEFGMTYKFIEADGFLI
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCCEEEEEECCCEEE
NEKVEMLLSGDSVTALCKSMGLGVMGISEALARLSPDLLVVLGDRFEALAGAQAAMIHRI
CCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHHHHHHCCHHHHHHHC
PIAHLHGGEATEGLIDEAIRHSITKMSHLHFVAAEAYRNKVIQLGESPDRVFNFGATGID
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHEECCCCCCC
NIKRLPLFNREEVEERIPVLKGAKGPVFLVTYHPVTLLNSSPEQAMADLLSAIEEFSDAC
CHHHCCCCCHHHHHHHCCHHCCCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHCCCEE
VILTKSNADTAGRVINEMIDQFCLKHPERAMSSVSLGQKLYLSVMSIANVVVGNSSSGII
EEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
EAPAMNIPTVNIGPRQQGRAKAPSVLDCNETKSEIVSGIQTVLENSFMASRKDKHVYGDG
ECCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
NTAVKVAEVLASYDLDGIIFKKFYSIDGVK
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRRICVLSGTRADYGLLYWLMKELQTYSSVDLQIIATGMHLSPEFGMTYKFIEADGFLI
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCCEEEEEECCCEEE
NEKVEMLLSGDSVTALCKSMGLGVMGISEALARLSPDLLVVLGDRFEALAGAQAAMIHRI
CCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHHHHHHCCHHHHHHHC
PIAHLHGGEATEGLIDEAIRHSITKMSHLHFVAAEAYRNKVIQLGESPDRVFNFGATGID
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHEECCCCCCC
NIKRLPLFNREEVEERIPVLKGAKGPVFLVTYHPVTLLNSSPEQAMADLLSAIEEFSDAC
CHHHCCCCCHHHHHHHCCHHCCCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHCCCEE
VILTKSNADTAGRVINEMIDQFCLKHPERAMSSVSLGQKLYLSVMSIANVVVGNSSSGII
EEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
EAPAMNIPTVNIGPRQQGRAKAPSVLDCNETKSEIVSGIQTVLENSFMASRKDKHVYGDG
ECCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
NTAVKVAEVLASYDLDGIIFKKFYSIDGVK
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]