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The map label for this gene is gmk [H]

Identifier: 42523073

GI number: 42523073

Start: 1493569

End: 1494039

Strand: Direct

Name: gmk [H]

Synonym: Bd1568

Alternate gene names: 42523073

Gene position: 1493569-1494039 (Clockwise)

Preceding gene: 42523072

Following gene: 42523074

Centisome position: 39.48

GC content: 48.62

Gene sequence:

>471_bases
TTGGTGGATATCGTCACTTTCACAACGCGCTCTATCCGCCAGGGAGAGACGCCGGGTCTGCAGTACAATTTCATTGATCA
TGCTGATTTTGAACAGAAGATCAAAGAGGGCTTCTTTGTGGAGTGGGCGAAGGTTCACACCAATTTCTATGGAACCTCAT
ATTCGTCCCTGGAAACAGCCTGGAATCAGGGTAAAACCGCCATTATGGACATCGACATCCAGGGTGTGGCGACCTTTAAG
TCCAAGTTCCCGGACGCTAAAACCGTCTTTATCCATCCCCCGAGTATTGACGAGCTGCGTCGTCGCATTGAAAAGCGCGA
TGGCAAGGTCCCTGCGGACATTGAAGTTCGTATGGCCAATGCCGAAAAGGAGATCCGTGAGGCCTCCAAGTTCGATTATC
AGATCGTCAACGACGTGTTTGAGAAATCCTATGGGGAATTTAAGAAAATCGTTGAAGATTTGCTAGCTTAG

Upstream 100 bases:

>100_bases
ACGTTCAGTAATTATGAAAACTCGCATGATTATCGTCGCCGCTCCAAGTGGCGCAGGAAAAAGCAGCTTTGTCGAAAGGA
TCACCCGGGAGGATTCCCGA

Downstream 100 bases:

>100_bases
CTGTAATTTGGCCTGATCTATTTGCTGGAGGCGTAATGGCTCGTGTAACCGTTGAAGATTGCTTGGAAAAAGTACCTAAC
AGATTTGCCCTTGTTTTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MVDIVTFTTRSIRQGETPGLQYNFIDHADFEQKIKEGFFVEWAKVHTNFYGTSYSSLETAWNQGKTAIMDIDIQGVATFK
SKFPDAKTVFIHPPSIDELRRRIEKRDGKVPADIEVRMANAEKEIREASKFDYQIVNDVFEKSYGEFKKIVEDLLA

Sequences:

>Translated_156_residues
MVDIVTFTTRSIRQGETPGLQYNFIDHADFEQKIKEGFFVEWAKVHTNFYGTSYSSLETAWNQGKTAIMDIDIQGVATFK
SKFPDAKTVFIHPPSIDELRRRIEKRDGKVPADIEVRMANAEKEIREASKFDYQIVNDVFEKSYGEFKKIVEDLLA
>Mature_156_residues
MVDIVTFTTRSIRQGETPGLQYNFIDHADFEQKIKEGFFVEWAKVHTNFYGTSYSSLETAWNQGKTAIMDIDIQGVATFK
SKFPDAKTVFIHPPSIDELRRRIEKRDGKVPADIEVRMANAEKEIREASKFDYQIVNDVFEKSYGEFKKIVEDLLA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=154, Percent_Identity=29.8701298701299, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI226874833, Length=154, Percent_Identity=29.8701298701299, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4504221, Length=154, Percent_Identity=29.8701298701299, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI38570142, Length=153, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI21361598, Length=161, Percent_Identity=26.7080745341615, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=28.2208588957055, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI192447426, Length=155, Percent_Identity=29.0322580645161, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4557529, Length=155, Percent_Identity=29.0322580645161, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=147, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193203132, Length=155, Percent_Identity=34.8387096774194, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17508835, Length=155, Percent_Identity=34.8387096774194, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17557440, Length=150, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=151, Percent_Identity=38.4105960264901, Blast_Score=109, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45554481, Length=146, Percent_Identity=30.8219178082192, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI85724806, Length=146, Percent_Identity=30.8219178082192, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077626, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007136, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640542, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554489, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 18022; Mature: 18022

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIVTFTTRSIRQGETPGLQYNFIDHADFEQKIKEGFFVEWAKVHTNFYGTSYSSLETA
CCEEEEECCHHHHCCCCCCEEEECCCCCCHHHHHHCCHHEEHHHHHHHHCCCCHHHHHHH
WNQGKTAIMDIDIQGVATFKSKFPDAKTVFIHPPSIDELRRRIEKRDGKVPADIEVRMAN
HCCCCEEEEEEECCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
AEKEIREASKFDYQIVNDVFEKSYGEFKKIVEDLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDIVTFTTRSIRQGETPGLQYNFIDHADFEQKIKEGFFVEWAKVHTNFYGTSYSSLETA
CCEEEEECCHHHHCCCCCCEEEECCCCCCHHHHHHCCHHEEHHHHHHHHCCCCHHHHHHH
WNQGKTAIMDIDIQGVATFKSKFPDAKTVFIHPPSIDELRRRIEKRDGKVPADIEVRMAN
HCCCCEEEEEEECCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
AEKEIREASKFDYQIVNDVFEKSYGEFKKIVEDLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA