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The map label for this gene is lpxB [H]

Identifier: 42523005

GI number: 42523005

Start: 1417254

End: 1418402

Strand: Direct

Name: lpxB [H]

Synonym: Bd1498

Alternate gene names: 42523005

Gene position: 1417254-1418402 (Clockwise)

Preceding gene: 42523004

Following gene: 42523006

Centisome position: 37.46

GC content: 51.26

Gene sequence:

>1149_bases
ATGGATCAGGTTCTGATTGTGGCGGCGGAAGCCTCCAGTGTGACCTATGCCCAAAGAATTCTGGAAGCCTGGAAGGCCCA
GGGCCGCAAAGTCCATGCTTTCGGTGTGGGCAGCCAGGATATGGAAGACATCGGCTTTGAACGCCTTGGCAAATCTGAAG
AGATGGCCGTTGTCGGTGCCGCTGAGATCATCAGTGCGTATTCCCACCTGAAAAGTGTTTTTGACAGCCTGGTGGCGGAA
GCTGAAAAGCGCCGTCCGAAGGTGGCGATCGTGATGGACTATCCGGAATTCAACCTGATGCTGGCGAAAAAACTGCACGC
CTTGGGTATTCCGGTGGTTTACTACATTTCTCCGCAGGTGTGGGCATGGCGCAAAGGCCGTGTGAAGACCATCAAGAAAT
ACTGTAAAAAAGTATTCGTTCTGTTCCCGTTTGAAGTGCCTTTCTATGAAGAGCACGGCGTGCCGGTGGAGTTCGTCGGT
CATCCGCTTTTGGATGAATTGGACGAGCGCCTGATTGACGATTTGGAGTATCGCAAGAACCACCGCAATCAGTGTGGTAT
TCGGGACAGCGAAATTGTGCTGGGTTTGATGCCGGGCAGCCGTCGTCTGGAAGTGAAGCAGCATCTGGACATTCAGTTGG
ATGCAGCTCGCATTCTTTCCAAAAAGTTCCCGAATCTGAAAGTTTTGATTCTGACCGCGCCGACCTTTACTAAAGAGTAC
ATGCAGGACCGTCTCGAAAACTTCCGACTGCCTTATATGTTGTTGAAGGATGAACCGTTCAGAATGATTCATCTGGTGGA
CATGATGCTGGTGGCTTCAGGAACTGCGACCCTGCAAGTGGGGCTTCTGAAAAAACCGATGGTCATCATGTACAAGATGA
AGTGGTTGACCGGCGTGTTTGCCAAACTCTTCGTTCGTGGGACCAAGTATTTTGGTCTGGTGAATCTGATTCTGAACAAA
GAAGCGGTGCCAGAGCTGTTCCAAAGCGAAGTCACTGCTGAAAATTTGGCAGCCGAGCTGGAGCGCTATGTTCTGGATAA
AAAGTACCATGACTCTGTGGTTTCTGATCTCGGGCAGGTTCGTCAGTATCTCGGCGACAAAGGGGCCACCCAGCGCGTGG
TGAAAGCCCTGGAAGAGTACTTCGTCTGA

Upstream 100 bases:

>100_bases
TCGACTGTGTATTGAATGACAAACAACCTGTCGTCACAGGTCTTGACGGGTTGAAAGCCCTGAAAGCCATCGAAGACGTG
CAGAGAATGATTGAGGGCTG

Downstream 100 bases:

>100_bases
TGAGAGCCTATCTTCGTCCATTGTCATTTTTGTATGATCAAGTCGTAGGGGTGAAAAACAACCTCTACGACCGCGGTGTT
TTCGGGGTGTTTAAAGCTCC

Product: lipid A disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDQVLIVAAEASSVTYAQRILEAWKAQGRKVHAFGVGSQDMEDIGFERLGKSEEMAVVGAAEIISAYSHLKSVFDSLVAE
AEKRRPKVAIVMDYPEFNLMLAKKLHALGIPVVYYISPQVWAWRKGRVKTIKKYCKKVFVLFPFEVPFYEEHGVPVEFVG
HPLLDELDERLIDDLEYRKNHRNQCGIRDSEIVLGLMPGSRRLEVKQHLDIQLDAARILSKKFPNLKVLILTAPTFTKEY
MQDRLENFRLPYMLLKDEPFRMIHLVDMMLVASGTATLQVGLLKKPMVIMYKMKWLTGVFAKLFVRGTKYFGLVNLILNK
EAVPELFQSEVTAENLAAELERYVLDKKYHDSVVSDLGQVRQYLGDKGATQRVVKALEEYFV

Sequences:

>Translated_382_residues
MDQVLIVAAEASSVTYAQRILEAWKAQGRKVHAFGVGSQDMEDIGFERLGKSEEMAVVGAAEIISAYSHLKSVFDSLVAE
AEKRRPKVAIVMDYPEFNLMLAKKLHALGIPVVYYISPQVWAWRKGRVKTIKKYCKKVFVLFPFEVPFYEEHGVPVEFVG
HPLLDELDERLIDDLEYRKNHRNQCGIRDSEIVLGLMPGSRRLEVKQHLDIQLDAARILSKKFPNLKVLILTAPTFTKEY
MQDRLENFRLPYMLLKDEPFRMIHLVDMMLVASGTATLQVGLLKKPMVIMYKMKWLTGVFAKLFVRGTKYFGLVNLILNK
EAVPELFQSEVTAENLAAELERYVLDKKYHDSVVSDLGQVRQYLGDKGATQRVVKALEEYFV
>Mature_382_residues
MDQVLIVAAEASSVTYAQRILEAWKAQGRKVHAFGVGSQDMEDIGFERLGKSEEMAVVGAAEIISAYSHLKSVFDSLVAE
AEKRRPKVAIVMDYPEFNLMLAKKLHALGIPVVYYISPQVWAWRKGRVKTIKKYCKKVFVLFPFEVPFYEEHGVPVEFVG
HPLLDELDERLIDDLEYRKNHRNQCGIRDSEIVLGLMPGSRRLEVKQHLDIQLDAARILSKKFPNLKVLILTAPTFTKEY
MQDRLENFRLPYMLLKDEPFRMIHLVDMMLVASGTATLQVGLLKKPMVIMYKMKWLTGVFAKLFVRGTKYFGLVNLILNK
EAVPELFQSEVTAENLAAELERYVLDKKYHDSVVSDLGQVRQYLGDKGATQRVVKALEEYFV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=342, Percent_Identity=32.7485380116959, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43765; Mature: 43765

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQVLIVAAEASSVTYAQRILEAWKAQGRKVHAFGVGSQDMEDIGFERLGKSEEMAVVGA
CCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCHHHCCCCCCEEEHHH
AEIISAYSHLKSVFDSLVAEAEKRRPKVAIVMDYPEFNLMLAKKLHALGIPVVYYISPQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCE
WAWRKGRVKTIKKYCKKVFVLFPFEVPFYEEHGVPVEFVGHPLLDELDERLIDDLEYRKN
EEECCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHC
HRNQCGIRDSEIVLGLMPGSRRLEVKQHLDIQLDAARILSKKFPNLKVLILTAPTFTKEY
CCCCCCCCCCCEEEEECCCCCCEEHHHCCCEEEHHHHHHHHCCCCEEEEEEECCHHHHHH
MQDRLENFRLPYMLLKDEPFRMIHLVDMMLVASGTATLQVGLLKKPMVIMYKMKWLTGVF
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
AKLFVRGTKYFGLVNLILNKEAVPELFQSEVTAENLAAELERYVLDKKYHDSVVSDLGQV
HHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RQYLGDKGATQRVVKALEEYFV
HHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQVLIVAAEASSVTYAQRILEAWKAQGRKVHAFGVGSQDMEDIGFERLGKSEEMAVVGA
CCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCHHHCCCCCCEEEHHH
AEIISAYSHLKSVFDSLVAEAEKRRPKVAIVMDYPEFNLMLAKKLHALGIPVVYYISPQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCE
WAWRKGRVKTIKKYCKKVFVLFPFEVPFYEEHGVPVEFVGHPLLDELDERLIDDLEYRKN
EEECCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHC
HRNQCGIRDSEIVLGLMPGSRRLEVKQHLDIQLDAARILSKKFPNLKVLILTAPTFTKEY
CCCCCCCCCCCEEEEECCCCCCEEHHHCCCEEEHHHHHHHHCCCCEEEEEEECCHHHHHH
MQDRLENFRLPYMLLKDEPFRMIHLVDMMLVASGTATLQVGLLKKPMVIMYKMKWLTGVF
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
AKLFVRGTKYFGLVNLILNKEAVPELFQSEVTAENLAAELERYVLDKKYHDSVVSDLGQV
HHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RQYLGDKGATQRVVKALEEYFV
HHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA