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The map label for this gene is lpxK

Identifier: 42523006

GI number: 42523006

Start: 1418402

End: 1419421

Strand: Direct

Name: lpxK

Synonym: Bd1499

Alternate gene names: 42523006

Gene position: 1418402-1419421 (Clockwise)

Preceding gene: 42523005

Following gene: 42523007

Centisome position: 37.49

GC content: 50.98

Gene sequence:

>1020_bases
ATGAGAGCCTATCTTCGTCCATTGTCATTTTTGTATGATCAAGTCGTAGGGGTGAAAAACAACCTCTACGACCGCGGTGT
TTTCGGGGTGTTTAAAGCTCCGGTGCCGGTGGTCAGTATTGGAAATCTGACGGTGGGTGGAACGGGTAAGACTCCGATCA
CGGATTTTTGTCTGAAGTCCCTGGTGGCTGACGGCAAAAAAGTGGCGGTGATCAGCCGATCTTACCGCGCGGATGCTTCG
GCTCCATGTCTGGTGGATGTGGATCATCCTTTTGCCGCAAGATATTTCGGCGATGAACCCGTGTTGCTCGCACAAGCCAA
CCCGCAGGTGTCTGTCTATGTCGGCCCCAGCAAGTGGCGCACGGCCCGTTATGCCGTGGAAAAACATAAATATGACCTGT
TGATTGTGGACGATGGTTTTCAACACCGTCGCCTGCATCGGGATTTGAATATCGTGATTCTGGATGCGACGGAAAGTCTT
TCTAACTATGAAGTCCTTCCCGAAGGCCGGGCTCGTGAATCCTGGGCCGGGATTGAACGCGCGGATGTGTTAATTCTTTC
CAAGTGCAATCTGGCGCCCGAAGATGAGTTGAAGGCCCTGGAGGCGCGGCTTCCGAAGAATAAGGAAGTCCTTTATTTCG
GCTACGAGATTCAGCAGTGCCAGAACGTCAAGACCGGCCAAGTGCTTCATCGGGACGAGCTGAAAGGCAAAAAACTTTTC
CTGGTGTCTGCGATTGCACGGCCGGATGTTTTTGAAAAAATGATGAGAGAAATCGGCGAGGTTTCAAACCAAAGCCTGCA
TTTCCGCGATCATCATCAGTACACCGCCGACGATGTGAAGAATATCGAAAATGCGTTTAAGAAATCCCAGGCGGACTATC
TTGTCACCACCGGCAAGGATGCAGTGAAGCTCCGTCAGTTGTTCAATGATACCGCCATCCTGTGGAGCACTTCGTTGGAA
GTTGCAGAGTCAGGCAGGAAGGGACGCCTTCATGAGATTATTACTCAAGTTCTTCGTTAA

Upstream 100 bases:

>100_bases
ATGACTCTGTGGTTTCTGATCTCGGGCAGGTTCGTCAGTATCTCGGCGACAAAGGGGCCACCCAGCGCGTGGTGAAAGCC
CTGGAAGAGTACTTCGTCTG

Downstream 100 bases:

>100_bases
TTTGATGGTCTTTATCAGTTCCCTGGTGCCGCGCCGTTGGTTGCGCAAGTCCGGGTCCTGGGTGGGCTTTTTGTGGTTTG
ATGTCTTTGGTTTTCGCAAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRAYLRPLSFLYDQVVGVKNNLYDRGVFGVFKAPVPVVSIGNLTVGGTGKTPITDFCLKSLVADGKKVAVISRSYRADAS
APCLVDVDHPFAARYFGDEPVLLAQANPQVSVYVGPSKWRTARYAVEKHKYDLLIVDDGFQHRRLHRDLNIVILDATESL
SNYEVLPEGRARESWAGIERADVLILSKCNLAPEDELKALEARLPKNKEVLYFGYEIQQCQNVKTGQVLHRDELKGKKLF
LVSAIARPDVFEKMMREIGEVSNQSLHFRDHHQYTADDVKNIENAFKKSQADYLVTTGKDAVKLRQLFNDTAILWSTSLE
VAESGRKGRLHEIITQVLR

Sequences:

>Translated_339_residues
MRAYLRPLSFLYDQVVGVKNNLYDRGVFGVFKAPVPVVSIGNLTVGGTGKTPITDFCLKSLVADGKKVAVISRSYRADAS
APCLVDVDHPFAARYFGDEPVLLAQANPQVSVYVGPSKWRTARYAVEKHKYDLLIVDDGFQHRRLHRDLNIVILDATESL
SNYEVLPEGRARESWAGIERADVLILSKCNLAPEDELKALEARLPKNKEVLYFGYEIQQCQNVKTGQVLHRDELKGKKLF
LVSAIARPDVFEKMMREIGEVSNQSLHFRDHHQYTADDVKNIENAFKKSQADYLVTTGKDAVKLRQLFNDTAILWSTSLE
VAESGRKGRLHEIITQVLR
>Mature_339_residues
MRAYLRPLSFLYDQVVGVKNNLYDRGVFGVFKAPVPVVSIGNLTVGGTGKTPITDFCLKSLVADGKKVAVISRSYRADAS
APCLVDVDHPFAARYFGDEPVLLAQANPQVSVYVGPSKWRTARYAVEKHKYDLLIVDDGFQHRRLHRDLNIVILDATESL
SNYEVLPEGRARESWAGIERADVLILSKCNLAPEDELKALEARLPKNKEVLYFGYEIQQCQNVKTGQVLHRDELKGKKLF
LVSAIARPDVFEKMMREIGEVSNQSLHFRDHHQYTADDVKNIENAFKKSQADYLVTTGKDAVKLRQLFNDTAILWSTSLE
VAESGRKGRLHEIITQVLR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=326, Percent_Identity=30.3680981595092, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_BDEBA (Q6MMX4)

Other databases:

- EMBL:   BX842650
- RefSeq:   NP_968386.1
- GeneID:   2735568
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1499
- NMPDR:   fig|264462.1.peg.1356
- HOGENOM:   HBG663914
- OMA:   IVDDGFQ
- PhylomeDB:   Q6MMX4
- BioCyc:   BBAC264462:BD1499-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38203; Mature: 38203

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYLRPLSFLYDQVVGVKNNLYDRGVFGVFKAPVPVVSIGNLTVGGTGKTPITDFCLKS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCEEECCCCCCCHHHHHHHH
LVADGKKVAVISRSYRADASAPCLVDVDHPFAARYFGDEPVLLAQANPQVSVYVGPSKWR
HHCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEECCCEEEEEECCCHHH
TARYAVEKHKYDLLIVDDGFQHRRLHRDLNIVILDATESLSNYEVLPEGRARESWAGIER
HHHHHHHHCCEEEEEEECCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCCCHHHCCCCC
ADVLILSKCNLAPEDELKALEARLPKNKEVLYFGYEIQQCQNVKTGQVLHRDELKGKKLF
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCCEEEHHHCCCCEEE
LVSAIARPDVFEKMMREIGEVSNQSLHFRDHHQYTADDVKNIENAFKKSQADYLVTTGKD
EEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCH
AVKLRQLFNDTAILWSTSLEVAESGRKGRLHEIITQVLR
HHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHC
>Mature Secondary Structure
MRAYLRPLSFLYDQVVGVKNNLYDRGVFGVFKAPVPVVSIGNLTVGGTGKTPITDFCLKS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCEEECCCCCCCHHHHHHHH
LVADGKKVAVISRSYRADASAPCLVDVDHPFAARYFGDEPVLLAQANPQVSVYVGPSKWR
HHCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEECCCEEEEEECCCHHH
TARYAVEKHKYDLLIVDDGFQHRRLHRDLNIVILDATESLSNYEVLPEGRARESWAGIER
HHHHHHHHCCEEEEEEECCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCCCHHHCCCCC
ADVLILSKCNLAPEDELKALEARLPKNKEVLYFGYEIQQCQNVKTGQVLHRDELKGKKLF
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCCCCEEEHHHCCCCEEE
LVSAIARPDVFEKMMREIGEVSNQSLHFRDHHQYTADDVKNIENAFKKSQADYLVTTGKD
EEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCH
AVKLRQLFNDTAILWSTSLEVAESGRKGRLHEIITQVLR
HHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA