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The map label for this gene is phoR [H]

Identifier: 42522578

GI number: 42522578

Start: 965964

End: 967397

Strand: Direct

Name: phoR [H]

Synonym: Bd1018

Alternate gene names: 42522578

Gene position: 965964-967397 (Clockwise)

Preceding gene: 42522577

Following gene: 42522579

Centisome position: 25.53

GC content: 50.56

Gene sequence:

>1434_bases
ATGAAGCGATTTATCCGATTCCCATGGCGAGTTTACTGGCGCTACTTCTCTTGGCAGGTAGTGGCCTTCAATGGTCTGTA
TCTGGCGGTCATTTCTGTTATCGATGTTCGCCACGGAGTTCGTCCATTTGTCTATAACGAAGCCCTGCTGAATTTTTTTG
TTTTCAGTATTCTTGTTTCTGCCATCACATCCTATCGTTTTGCAAAACCCATTCACCGGGTGATCCTGAAAGCTTTGCGC
ATTTCCAGCAAACGCACCTTCGGCAGTCTGGTGAAAGAACAAGAAGACGATCTGGCAGACGATGAAACCGCTGACATTTC
CGAGCTGGAACTGGCTTTGGACCGCATTCATCGCAAGATGAAAAGCCGCAAAGCGCGCTATCTGCAGTCCCAGGAAGAAT
CCCAGGCCTTTATGAGCGCCGTGGCCGAGGGCCTGGTATCGGTCAGTCTTGATGAAAAGATTCTTTATTTTAATTCTCAA
TTTGCCGCGCAATTCCTGTCGTCCGACCTTCTGAACGGGCAGATTCTGCGATTGAAAGACGCCATTCGTTCTTCCGATGT
TTTGGAAGGCTTTGGCAAAACCATCAAGATCGGCAAGGTTCAGCGTTTCACCGTGAAACTTCCGACCTTGATCGACAATC
AGCCCCGCTTCTTTGCCGTGTCGGTGAACCCGATCCGCAATGAAAAGACGCAAGAGATTTACGGTGTTGTGGGGATCTTC
CATGACATCACCGAGATGAAACGGGCCGAGCAGATCCGCATGGATTTCGTTGGAAACGCGTCTCACGAGCTGCGCACTCC
ACTGACGTCCATCAAGGGCTATGTCGACACACTGAAAGAGGACGTAAAAACCGGCCAGATTCAGCAGGCCGGCAAGTTCC
TGGATATTGTTTCTCGTAATATCGACCGTCTGATGGATCTGGTGAATGACATGCTTAGCATCAACACTCTGGAGGCATCA
AATTCCGAGCTGAAGCTTGAAATGATTCATCCGCTGGCGATTTCTGAGCATGTGGTGTCAGAGCTGGCCGTGATGGCGGC
GGAAAAAAACATCACCATCCGCGTGAACGGCGATGTGCCACCGTTTTTGGCAGATGCCCGCAAAGTGGAGCAGGTTCTGC
GCAATCTGGTGTCCAATGCCGTGAAATACATTCCCTCTGGCAAGACCATCCAGATTCGTTGGGAACGCGATATCAAAGAA
TACATAATTTTGCGAGTGATCGACGACGGGCAGGGCATTCCTGAGCAACACTTGGATCGTCTGTTTGAGCGCTTCTATCG
CATCGACAAGGGCCGCACCCGCGATGCCGGGGGCACCGGACTTGGTCTGGCCATTGTGAAGCATATTATGCAAAGTCACG
GTGGTACGGTCGCGGTGAAGAGTATTGTCGACCAGGGATCTGAATTTATTTGCTCTTTCCCGATCCGAAAGTAA

Upstream 100 bases:

>100_bases
TCGACACCCACGTCTTCGGATTACGCAAGAAGTTAGGGGAGTGGGGAGACCGTATTGAGACTATCCGTGGCGTTGGATAT
CGGGTTAAAGTAGACATCGC

Downstream 100 bases:

>100_bases
AATTTGGGGGATGAACACCGATCATCCCTTTTATCGTCATTTTGAAAAAGTCTATGGTTCCCGCTGGCCGGGCCTCTTCG
CTGCCCTGCAAACCCGTGAA

Product: phosphate regulon sensor protein phoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKRFIRFPWRVYWRYFSWQVVAFNGLYLAVISVIDVRHGVRPFVYNEALLNFFVFSILVSAITSYRFAKPIHRVILKALR
ISSKRTFGSLVKEQEDDLADDETADISELELALDRIHRKMKSRKARYLQSQEESQAFMSAVAEGLVSVSLDEKILYFNSQ
FAAQFLSSDLLNGQILRLKDAIRSSDVLEGFGKTIKIGKVQRFTVKLPTLIDNQPRFFAVSVNPIRNEKTQEIYGVVGIF
HDITEMKRAEQIRMDFVGNASHELRTPLTSIKGYVDTLKEDVKTGQIQQAGKFLDIVSRNIDRLMDLVNDMLSINTLEAS
NSELKLEMIHPLAISEHVVSELAVMAAEKNITIRVNGDVPPFLADARKVEQVLRNLVSNAVKYIPSGKTIQIRWERDIKE
YIILRVIDDGQGIPEQHLDRLFERFYRIDKGRTRDAGGTGLGLAIVKHIMQSHGGTVAVKSIVDQGSEFICSFPIRK

Sequences:

>Translated_477_residues
MKRFIRFPWRVYWRYFSWQVVAFNGLYLAVISVIDVRHGVRPFVYNEALLNFFVFSILVSAITSYRFAKPIHRVILKALR
ISSKRTFGSLVKEQEDDLADDETADISELELALDRIHRKMKSRKARYLQSQEESQAFMSAVAEGLVSVSLDEKILYFNSQ
FAAQFLSSDLLNGQILRLKDAIRSSDVLEGFGKTIKIGKVQRFTVKLPTLIDNQPRFFAVSVNPIRNEKTQEIYGVVGIF
HDITEMKRAEQIRMDFVGNASHELRTPLTSIKGYVDTLKEDVKTGQIQQAGKFLDIVSRNIDRLMDLVNDMLSINTLEAS
NSELKLEMIHPLAISEHVVSELAVMAAEKNITIRVNGDVPPFLADARKVEQVLRNLVSNAVKYIPSGKTIQIRWERDIKE
YIILRVIDDGQGIPEQHLDRLFERFYRIDKGRTRDAGGTGLGLAIVKHIMQSHGGTVAVKSIVDQGSEFICSFPIRK
>Mature_477_residues
MKRFIRFPWRVYWRYFSWQVVAFNGLYLAVISVIDVRHGVRPFVYNEALLNFFVFSILVSAITSYRFAKPIHRVILKALR
ISSKRTFGSLVKEQEDDLADDETADISELELALDRIHRKMKSRKARYLQSQEESQAFMSAVAEGLVSVSLDEKILYFNSQ
FAAQFLSSDLLNGQILRLKDAIRSSDVLEGFGKTIKIGKVQRFTVKLPTLIDNQPRFFAVSVNPIRNEKTQEIYGVVGIF
HDITEMKRAEQIRMDFVGNASHELRTPLTSIKGYVDTLKEDVKTGQIQQAGKFLDIVSRNIDRLMDLVNDMLSINTLEAS
NSELKLEMIHPLAISEHVVSELAVMAAEKNITIRVNGDVPPFLADARKVEQVLRNLVSNAVKYIPSGKTIQIRWERDIKE
YIILRVIDDGQGIPEQHLDRLFERFYRIDKGRTRDAGGTGLGLAIVKHIMQSHGGTVAVKSIVDQGSEFICSFPIRK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=269, Percent_Identity=31.9702602230483, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=34.051724137931, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=32, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=29.0598290598291, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=28.2868525896414, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=29.7872340425532, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=29.6, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=31.8385650224215, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=25, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=24.6808510638298, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=30, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=28.0442804428044, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=31.304347826087, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=28, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790551, Length=264, Percent_Identity=29.9242424242424, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=29.646017699115, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=246, Percent_Identity=28.0487804878049, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=30.4545454545455, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789808, Length=263, Percent_Identity=26.2357414448669, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54355; Mature: 54355

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFIRFPWRVYWRYFSWQVVAFNGLYLAVISVIDVRHGVRPFVYNEALLNFFVFSILVS
CCCCHHCHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AITSYRFAKPIHRVILKALRISSKRTFGSLVKEQEDDLADDETADISELELALDRIHRKM
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KSRKARYLQSQEESQAFMSAVAEGLVSVSLDEKILYFNSQFAAQFLSSDLLNGQILRLKD
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECHHHHHHHHHHHHCCCHHHHHHH
AIRSSDVLEGFGKTIKIGKVQRFTVKLPTLIDNQPRFFAVSVNPIRNEKTQEIYGVVGIF
HHHHHHHHHHCCCEEEECCEEEEEEECCHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
HDITEMKRAEQIRMDFVGNASHELRTPLTSIKGYVDTLKEDVKTGQIQQAGKFLDIVSRN
HHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IDRLMDLVNDMLSINTLEASNSELKLEMIHPLAISEHVVSELAVMAAEKNITIRVNGDVP
HHHHHHHHHHHHHCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PFLADARKVEQVLRNLVSNAVKYIPSGKTIQIRWERDIKEYIILRVIDDGQGIPEQHLDR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHH
LFERFYRIDKGRTRDAGGTGLGLAIVKHIMQSHGGTVAVKSIVDQGSEFICSFPIRK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure
MKRFIRFPWRVYWRYFSWQVVAFNGLYLAVISVIDVRHGVRPFVYNEALLNFFVFSILVS
CCCCHHCHHHHHHHHHHEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AITSYRFAKPIHRVILKALRISSKRTFGSLVKEQEDDLADDETADISELELALDRIHRKM
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KSRKARYLQSQEESQAFMSAVAEGLVSVSLDEKILYFNSQFAAQFLSSDLLNGQILRLKD
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECHHHHHHHHHHHHCCCHHHHHHH
AIRSSDVLEGFGKTIKIGKVQRFTVKLPTLIDNQPRFFAVSVNPIRNEKTQEIYGVVGIF
HHHHHHHHHHCCCEEEECCEEEEEEECCHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
HDITEMKRAEQIRMDFVGNASHELRTPLTSIKGYVDTLKEDVKTGQIQQAGKFLDIVSRN
HHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IDRLMDLVNDMLSINTLEASNSELKLEMIHPLAISEHVVSELAVMAAEKNITIRVNGDVP
HHHHHHHHHHHHHCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PFLADARKVEQVLRNLVSNAVKYIPSGKTIQIRWERDIKEYIILRVIDDGQGIPEQHLDR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHH
LFERFYRIDKGRTRDAGGTGLGLAIVKHIMQSHGGTVAVKSIVDQGSEFICSFPIRK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]