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The map label for this gene is bfmBAB [H]

Identifier: 42522536

GI number: 42522536

Start: 921371

End: 922426

Strand: Direct

Name: bfmBAB [H]

Synonym: Bd0974

Alternate gene names: 42522536

Gene position: 921371-922426 (Clockwise)

Preceding gene: 42522535

Following gene: 42522537

Centisome position: 24.36

GC content: 51.8

Gene sequence:

>1056_bases
ATGGCAAGTATTGCTCAGGCCATCAGAATGGCCCTTCACTATGGTGAAGCCAACATGGGAGTTAAAGACATCTTCGGTCA
GGACGTGGGCGCACCACTGGGGGGCGTTTTCACAGCGACTCAAGGTTTGGAAACGGCGTGGAACTCCACTCTGGATGAAC
GTGGGATCATCAGCATGGCGATGGGTATCGCGATGGGTGGTGACCGCTGCGTGGCTGAAATCCAGTTTGCCGATTATATC
TTTAACACCATCGATCTTTTGAAAATTGCCGGTAACACTTTGTGGTGCACGAACGGTCAGATTCAACTGCCGATGGTGGT
GATGACTCCGGTGGGTGCGGGGATCTTTGGTTCCGTTTACCATTCTCACTCTTTCGATGCATGGGCCTCCCGCCTGCAAG
GCTGGAAGATCGTGATGCCGTCCAATCCGTTGGATGCTTACGGTTTGATGCTTTCTGCGATCGAAGATCCAAATCCGGTT
CTTTATTTGAAATCCAAGGCGCTGATGCGCCATAAAGGTGATGAGCTGATCCCAGGTGAACCTGCGGATGAAAAAGAGCT
TAAAGCCATGATCGATAAACCAGTTCAGAATTCTGAAGGCTGGAAACCTCGCTGGCCGGAACTTGAAAAGTACATGGTTC
CAATCGGCAAGGGCAAGATCACTCACGCGGGTGAACACATCACGGTTGTTACCTACAGCCGCATGGTGCACCTGTGTGAC
GAAGTGGCGGTGAAACTGGCGGAAGAAGGCATCTCTGTTGAGGTGATCGATCTGCGCTCGATTTATCCATACGACTGGCC
GATGATCAAAGCATCCATCGAAAAAACCGGCCGTGTATTGTTCGTGAACGAGGACACGGAAGTGACCAACTTCGGCGAAC
ATTTGGCTTACCGTGCGACTCAAGAGTGCTTCTATCAACTGATGGCGCGTCCGCGTGTTCTGGCCGGTAAAAACCTGCCG
GGCATCGGTCTGCACCCGAACCTTGAAAAGAACTCTGTGCCACAGATCCATGACATTGAACTTGCGATTCGTGAAGTCGT
AGCGGAAGTGCCGTAA

Upstream 100 bases:

>100_bases
GCGCTCAGGAACAAGCCCGCCAGGAACCGGTACCGACTCCGGAATCTGTTTGGGATCATGTTTACGTTAACAGCGAAAAT
GCAGATTGGAGAAAATTCTA

Downstream 100 bases:

>100_bases
ATGAAAAAAGAAATGTCCCACAGAAAAAAGGTCCGCCGTCGTGTGAATAAAAAAAGCACGGCTTTGGTATTCGATAAATA
CGAACTGTACCGCAAAGCGG

Product: 3-methyl-2-oxobutanoate dehydrogenase

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MASIAQAIRMALHYGEANMGVKDIFGQDVGAPLGGVFTATQGLETAWNSTLDERGIISMAMGIAMGGDRCVAEIQFADYI
FNTIDLLKIAGNTLWCTNGQIQLPMVVMTPVGAGIFGSVYHSHSFDAWASRLQGWKIVMPSNPLDAYGLMLSAIEDPNPV
LYLKSKALMRHKGDELIPGEPADEKELKAMIDKPVQNSEGWKPRWPELEKYMVPIGKGKITHAGEHITVVTYSRMVHLCD
EVAVKLAEEGISVEVIDLRSIYPYDWPMIKASIEKTGRVLFVNEDTEVTNFGEHLAYRATQECFYQLMARPRVLAGKNLP
GIGLHPNLEKNSVPQIHDIELAIREVVAEVP

Sequences:

>Translated_351_residues
MASIAQAIRMALHYGEANMGVKDIFGQDVGAPLGGVFTATQGLETAWNSTLDERGIISMAMGIAMGGDRCVAEIQFADYI
FNTIDLLKIAGNTLWCTNGQIQLPMVVMTPVGAGIFGSVYHSHSFDAWASRLQGWKIVMPSNPLDAYGLMLSAIEDPNPV
LYLKSKALMRHKGDELIPGEPADEKELKAMIDKPVQNSEGWKPRWPELEKYMVPIGKGKITHAGEHITVVTYSRMVHLCD
EVAVKLAEEGISVEVIDLRSIYPYDWPMIKASIEKTGRVLFVNEDTEVTNFGEHLAYRATQECFYQLMARPRVLAGKNLP
GIGLHPNLEKNSVPQIHDIELAIREVVAEVP
>Mature_350_residues
ASIAQAIRMALHYGEANMGVKDIFGQDVGAPLGGVFTATQGLETAWNSTLDERGIISMAMGIAMGGDRCVAEIQFADYIF
NTIDLLKIAGNTLWCTNGQIQLPMVVMTPVGAGIFGSVYHSHSFDAWASRLQGWKIVMPSNPLDAYGLMLSAIEDPNPVL
YLKSKALMRHKGDELIPGEPADEKELKAMIDKPVQNSEGWKPRWPELEKYMVPIGKGKITHAGEHITVVTYSRMVHLCDE
VAVKLAEEGISVEVIDLRSIYPYDWPMIKASIEKTGRVLFVNEDTEVTNFGEHLAYRATQECFYQLMARPRVLAGKNLPG
IGLHPNLEKNSVPQIHDIELAIREVVAEVP

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=333, Percent_Identity=31.8318318318318, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI34101272, Length=333, Percent_Identity=31.8318318318318, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI156564403, Length=332, Percent_Identity=30.7228915662651, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI291084858, Length=358, Percent_Identity=29.0502793296089, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17506935, Length=357, Percent_Identity=30.2521008403361, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17538422, Length=333, Percent_Identity=28.2282282282282, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319698, Length=339, Percent_Identity=28.6135693215339, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI160714832, Length=355, Percent_Identity=31.5492957746479, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI160714828, Length=355, Percent_Identity=31.5492957746479, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=29.8192771084337, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=29.8192771084337, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 38762; Mature: 38631

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIAQAIRMALHYGEANMGVKDIFGQDVGAPLGGVFTATQGLETAWNSTLDERGIISMA
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
MGIAMGGDRCVAEIQFADYIFNTIDLLKIAGNTLWCTNGQIQLPMVVMTPVGAGIFGSVY
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEEEEECCCCCHHHHHH
HSHSFDAWASRLQGWKIVMPSNPLDAYGLMLSAIEDPNPVLYLKSKALMRHKGDELIPGE
HCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCC
PADEKELKAMIDKPVQNSEGWKPRWPELEKYMVPIGKGKITHAGEHITVVTYSRMVHLCD
CCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCCCEEECCCEEEEEEHHHHHHHHH
EVAVKLAEEGISVEVIDLRSIYPYDWPMIKASIEKTGRVLFVNEDTEVTNFGEHLAYRAT
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
QECFYQLMARPRVLAGKNLPGIGLHPNLEKNSVPQIHDIELAIREVVAEVP
HHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASIAQAIRMALHYGEANMGVKDIFGQDVGAPLGGVFTATQGLETAWNSTLDERGIISMA
CHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
MGIAMGGDRCVAEIQFADYIFNTIDLLKIAGNTLWCTNGQIQLPMVVMTPVGAGIFGSVY
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEEEEECCCCCHHHHHH
HSHSFDAWASRLQGWKIVMPSNPLDAYGLMLSAIEDPNPVLYLKSKALMRHKGDELIPGE
HCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCC
PADEKELKAMIDKPVQNSEGWKPRWPELEKYMVPIGKGKITHAGEHITVVTYSRMVHLCD
CCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCCCEEECCCEEEEEEHHHHHHHHH
EVAVKLAEEGISVEVIDLRSIYPYDWPMIKASIEKTGRVLFVNEDTEVTNFGEHLAYRAT
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
QECFYQLMARPRVLAGKNLPGIGLHPNLEKNSVPQIHDIELAIREVVAEVP
HHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]