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The map label for this gene is esd [C]

Identifier: 42522469

GI number: 42522469

Start: 851960

End: 852790

Strand: Direct

Name: esd [C]

Synonym: Bd0899

Alternate gene names: 42522469

Gene position: 851960-852790 (Clockwise)

Preceding gene: 42522468

Following gene: 42522471

Centisome position: 22.52

GC content: 49.94

Gene sequence:

>831_bases
ATGAATCTGACACCTTTAAAAACGCATAAAACATTCCAGGGACTGACGCAGTTCTGGGAGCACGATTCTGCTGTGACTAA
AACCAAGATGAAGTTTTCAACCTTCATCCCCGAGGGCAAAGCCAAAGGCTGTGTGATCTGGCTTTCAGGTCTGACCTGCA
CCGATGAAAACTTCATCACCAAAGCAGGAGCACAAAAATATCTGGCAGAGCATCAGCTGATGGTGATCTGTCCGGACACT
TCGCCGCGGGGCTTACAGCTTCCCGGGGAACATGACACCTATGACTTCGGCTCTGGCGCGGGCTTTTACGTGGATGCGAC
AGTGGATGGTTATAAAGACCACTACAGGATGTACAGCTATGTGAATGATGAGCTTTATTCTCTGATACAGAAACAGTTTG
AAGTGTCTGCTGAGCACATCTCCATCATGGGGCATTCGATGGGGGGGCATGGTGCTTTGGTTCTGGGGTTGCGCAATCCC
GGGAAGTATCGTTCAGTTTCGGCGTTTTCACCGATTGTGAATCCGGCGCAGTGTCCTTGGGGGCAAAAAGCCTTCACTGG
ATATCTGGGGAGTGATGCCAGTGTGTGGTCCCAGTACGACGCCACAGAATTGGTAAGTAGTGGTGCCCGCCATCCGGCCA
AAATCCTGATTGATCAGGGAACGCAGGATGAATTCCTGCAAAAAGGCCAACTGCTGACTCAGAACTTTGAAGGTGCCTGC
AAAACGGCGGGGCAACCTTACGAAGTCAACTACCGAGAACAGTACGATCACAGCTATTACTTCATTGCGACTTTCATCGA
AAGTCACATCAAGTTTCACGCAAGTGTGTAA

Upstream 100 bases:

>100_bases
TTCACAATGCCACTTGAAGATATCAACAAAGCCTTTGATTATATGCATGAAGGAAAAAGCATCCGTTCTGTCATCAAGAT
GTAGAGCGGGCGGGGGATCC

Downstream 100 bases:

>100_bases
AGCAAAGAGGCCGGTTTCCCGGCCTCTTTTTTAACTGTTTTTAGATTTTCCCCATGTCCAGAACGAATCGATAGCGCACG
TCGCTTTTTAGAACGCGTTC

Product: esterase D

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNLTPLKTHKTFQGLTQFWEHDSAVTKTKMKFSTFIPEGKAKGCVIWLSGLTCTDENFITKAGAQKYLAEHQLMVICPDT
SPRGLQLPGEHDTYDFGSGAGFYVDATVDGYKDHYRMYSYVNDELYSLIQKQFEVSAEHISIMGHSMGGHGALVLGLRNP
GKYRSVSAFSPIVNPAQCPWGQKAFTGYLGSDASVWSQYDATELVSSGARHPAKILIDQGTQDEFLQKGQLLTQNFEGAC
KTAGQPYEVNYREQYDHSYYFIATFIESHIKFHASV

Sequences:

>Translated_276_residues
MNLTPLKTHKTFQGLTQFWEHDSAVTKTKMKFSTFIPEGKAKGCVIWLSGLTCTDENFITKAGAQKYLAEHQLMVICPDT
SPRGLQLPGEHDTYDFGSGAGFYVDATVDGYKDHYRMYSYVNDELYSLIQKQFEVSAEHISIMGHSMGGHGALVLGLRNP
GKYRSVSAFSPIVNPAQCPWGQKAFTGYLGSDASVWSQYDATELVSSGARHPAKILIDQGTQDEFLQKGQLLTQNFEGAC
KTAGQPYEVNYREQYDHSYYFIATFIESHIKFHASV
>Mature_276_residues
MNLTPLKTHKTFQGLTQFWEHDSAVTKTKMKFSTFIPEGKAKGCVIWLSGLTCTDENFITKAGAQKYLAEHQLMVICPDT
SPRGLQLPGEHDTYDFGSGAGFYVDATVDGYKDHYRMYSYVNDELYSLIQKQFEVSAEHISIMGHSMGGHGALVLGLRNP
GKYRSVSAFSPIVNPAQCPWGQKAFTGYLGSDASVWSQYDATELVSSGARHPAKILIDQGTQDEFLQKGQLLTQNFEGAC
KTAGQPYEVNYREQYDHSYYFIATFIESHIKFHASV

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=277, Percent_Identity=55.2346570397112, Blast_Score=315, Evalue=3e-86,
Organism=Escherichia coli, GI1788477, Length=273, Percent_Identity=49.8168498168498, Blast_Score=270, Evalue=9e-74,
Organism=Escherichia coli, GI1786551, Length=273, Percent_Identity=46.8864468864469, Blast_Score=259, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=43.0604982206406, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6322393, Length=276, Percent_Identity=38.768115942029, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45551932, Length=281, Percent_Identity=49.1103202846975, Blast_Score=282, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=49.1103202846975, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30830; Mature: 30830

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTPLKTHKTFQGLTQFWEHDSAVTKTKMKFSTFIPEGKAKGCVIWLSGLTCTDENFIT
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCHHH
KAGAQKYLAEHQLMVICPDTSPRGLQLPGEHDTYDFGSGAGFYVDATVDGYKDHYRMYSY
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHH
VNDELYSLIQKQFEVSAEHISIMGHSMGGHGALVLGLRNPGKYRSVSAFSPIVNPAQCPW
HHHHHHHHHHHHHHCCHHHEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC
GQKAFTGYLGSDASVWSQYDATELVSSGARHPAKILIDQGTQDEFLQKGQLLTQNFEGAC
CCHHHHEECCCCHHHHHHCCHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHCCCCCHH
KTAGQPYEVNYREQYDHSYYFIATFIESHIKFHASV
HCCCCCEECCHHHHCCCCEEEHHHHHHHHHEEECCC
>Mature Secondary Structure
MNLTPLKTHKTFQGLTQFWEHDSAVTKTKMKFSTFIPEGKAKGCVIWLSGLTCTDENFIT
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCHHH
KAGAQKYLAEHQLMVICPDTSPRGLQLPGEHDTYDFGSGAGFYVDATVDGYKDHYRMYSY
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHH
VNDELYSLIQKQFEVSAEHISIMGHSMGGHGALVLGLRNPGKYRSVSAFSPIVNPAQCPW
HHHHHHHHHHHHHHCCHHHEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC
GQKAFTGYLGSDASVWSQYDATELVSSGARHPAKILIDQGTQDEFLQKGQLLTQNFEGAC
CCHHHHEECCCCHHHHHHCCHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHCCCCCHH
KTAGQPYEVNYREQYDHSYYFIATFIESHIKFHASV
HCCCCCEECCHHHHCCCCEEEHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]