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The map label for this gene is adhC [H]

Identifier: 42522468

GI number: 42522468

Start: 850834

End: 851943

Strand: Direct

Name: adhC [H]

Synonym: Bd0898

Alternate gene names: 42522468

Gene position: 850834-851943 (Clockwise)

Preceding gene: 42522464

Following gene: 42522469

Centisome position: 22.49

GC content: 52.79

Gene sequence:

>1110_bases
ATGAAAATCAAAGCCGCAGTCGCCTGGAAAGCCGGAGCCCCCTTGTCTATCGAAGAAGTGGATCTGGAAGGACCCAAAAA
AGGCGAAGTCCTGATCAGGGTTGTTGCCACGGGCGTATGCCATACGGACGCCTTCACATTGTCCGGGGCGGATCCTGAAG
GTTTGTTTCCGGTGATTCTGGGCCACGAAGGTGGTGGTATCGTTGAGGAGGTCGGAGAAGGTGTGACCACTTTGAAAAAA
GGCGATCACGTGATTCCGCTTTATACTCCTGAATGCAAAGAGTGCAAATTCTGTCTGTCTGGTAAGACCAATCTGTGCGT
GCGCATCCGTGCGACTCAAGGCAAAGGGCTGATGCCGGATGGGACGTCCCGCTTTTCTAAAGACGGAAAAATGATTCATC
ACTATATGGGCTGCTCCACTTTCGCGGAATACACCGTCGTTCCGGAAATCGCTTTGGCGAAAGTCAATCCGGCCGCACCG
CTGGACAAAGTATGTTTGCTGGGGTGCGGAGTCACCACCGGGATCGGTGCTGTTTTGAACACGGCGAAGGTTGAAAAGGG
TGCGACTGTGGCGGTCTTTGGTTTGGGCGGCATCGGTCTGTCTGTCATTCAGGGCGCAAAAATGGCGGGGGCTTCCCGTA
TCATCGCGATCGACATCAACGACGCGAAATGGGAAATGGCGCAAAAATTCGGCGCCACGGACTTTGTAAATCCCAAGAAG
CACGACAAACCCATTCAGCAGGTGATTGTGGAAATGACCGAATGGGGCGTGGACTATTCCTTCGAGTGTGTGGGGAATAC
TCAGTTGATGCGTGCGGCATTGGAATGTGCGCACCGTGGCTGGGGGCAGTCCATCGTGATTGGTGTGGCTGGCGCCGGGC
AGGAGATTTCAACCCGTCCATTCCAACTGGTCACGGGCCGCGTGTGGAAGGGCTCTGCATTCGGTGGCGTAAAAGGACGT
ACCGAACTTCCAGGTTATGTGGAGCAATACATGTCTGGCGAAATCAACATTGATGACATGGTGACCTTCACAATGCCACT
TGAAGATATCAACAAAGCCTTTGATTATATGCATGAAGGAAAAAGCATCCGTTCTGTCATCAAGATGTAG

Upstream 100 bases:

>100_bases
TCTTATTGTTTCCATATAGAAACAGTATTGTTCCGTTCGTTGCCTAGTCAAGCGGGGGTTCGGAAATTATAATTCCTTCT
TATTAACTAAGGAGAATCAC

Downstream 100 bases:

>100_bases
AGCGGGCGGGGGATCCATGAATCTGACACCTTTAAAAACGCATAAAACATTCCAGGGACTGACGCAGTTCTGGGAGCACG
ATTCTGCTGTGACTAAAACC

Product: alcohol dehydrogenase / formaldehyde dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKIKAAVAWKAGAPLSIEEVDLEGPKKGEVLIRVVATGVCHTDAFTLSGADPEGLFPVILGHEGGGIVEEVGEGVTTLKK
GDHVIPLYTPECKECKFCLSGKTNLCVRIRATQGKGLMPDGTSRFSKDGKMIHHYMGCSTFAEYTVVPEIALAKVNPAAP
LDKVCLLGCGVTTGIGAVLNTAKVEKGATVAVFGLGGIGLSVIQGAKMAGASRIIAIDINDAKWEMAQKFGATDFVNPKK
HDKPIQQVIVEMTEWGVDYSFECVGNTQLMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRVWKGSAFGGVKGR
TELPGYVEQYMSGEINIDDMVTFTMPLEDINKAFDYMHEGKSIRSVIKM

Sequences:

>Translated_369_residues
MKIKAAVAWKAGAPLSIEEVDLEGPKKGEVLIRVVATGVCHTDAFTLSGADPEGLFPVILGHEGGGIVEEVGEGVTTLKK
GDHVIPLYTPECKECKFCLSGKTNLCVRIRATQGKGLMPDGTSRFSKDGKMIHHYMGCSTFAEYTVVPEIALAKVNPAAP
LDKVCLLGCGVTTGIGAVLNTAKVEKGATVAVFGLGGIGLSVIQGAKMAGASRIIAIDINDAKWEMAQKFGATDFVNPKK
HDKPIQQVIVEMTEWGVDYSFECVGNTQLMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRVWKGSAFGGVKGR
TELPGYVEQYMSGEINIDDMVTFTMPLEDINKAFDYMHEGKSIRSVIKM
>Mature_369_residues
MKIKAAVAWKAGAPLSIEEVDLEGPKKGEVLIRVVATGVCHTDAFTLSGADPEGLFPVILGHEGGGIVEEVGEGVTTLKK
GDHVIPLYTPECKECKFCLSGKTNLCVRIRATQGKGLMPDGTSRFSKDGKMIHHYMGCSTFAEYTVVPEIALAKVNPAAP
LDKVCLLGCGVTTGIGAVLNTAKVEKGATVAVFGLGGIGLSVIQGAKMAGASRIIAIDINDAKWEMAQKFGATDFVNPKK
HDKPIQQVIVEMTEWGVDYSFECVGNTQLMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRVWKGSAFGGVKGR
TELPGYVEQYMSGEINIDDMVTFTMPLEDINKAFDYMHEGKSIRSVIKM

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=65.8536585365854, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=50.408719346049, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=51.0752688172043, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=49.8637602179836, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=49.8637602179836, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=47.9674796747967, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=47.9564032697548, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=47.9564032697548, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=48.4764542936288, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI156627571, Length=363, Percent_Identity=26.1707988980716, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=69.5652173913043, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1788073, Length=382, Percent_Identity=27.4869109947644, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081918, Length=363, Percent_Identity=31.404958677686, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790045, Length=371, Percent_Identity=26.9541778975741, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=270, Percent_Identity=29.2592592592593, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25.2631578947368, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=24.7159090909091, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=262, Percent_Identity=27.4809160305344, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790718, Length=334, Percent_Identity=23.3532934131737, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=24.2774566473988, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=25.2717391304348, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=59.8382749326146, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=59.5174262734584, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=59.5870206489675, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17562878, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=368, Percent_Identity=26.9021739130435, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=362, Percent_Identity=26.2430939226519, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=361, Percent_Identity=25.4847645429363, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=61.0215053763441, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319621, Length=281, Percent_Identity=30.9608540925267, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.0718232044199, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.0718232044199, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=27.5280898876405, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=27.0096463022508, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=26.9021739130435, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=307, Percent_Identity=26.7100977198697, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=30.188679245283, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=354, Percent_Identity=25.1412429378531, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=64.3051771117166, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=27.2189349112426, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=265, Percent_Identity=26.7924528301887, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39411; Mature: 39411

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKAAVAWKAGAPLSIEEVDLEGPKKGEVLIRVVATGVCHTDAFTLSGADPEGLFPVIL
CCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
GHEGGGIVEEVGEGVTTLKKGDHVIPLYTPECKECKFCLSGKTNLCVRIRATQGKGLMPD
ECCCCCHHHHHCCCHHHHCCCCEEEEEECCCHHHCCEEECCCCCEEEEEEECCCCCCCCC
GTSRFSKDGKMIHHYMGCSTFAEYTVVPEIALAKVNPAAPLDKVCLLGCGVTTGIGAVLN
CCHHHCCCCHHHHHHHCHHHHHHEEECCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHH
TAKVEKGATVAVFGLGGIGLSVIQGAKMAGASRIIAIDINDAKWEMAQKFGATDFVNPKK
HHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCC
HDKPIQQVIVEMTEWGVDYSFECVGNTQLMRAALECAHRGWGQSIVIGVAGAGQEISTRP
CCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRTELPGYVEQYMSGEINIDDMVTFTMPLEDINKAFDYMHEG
EEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHCC
KSIRSVIKM
HHHHHHHCC
>Mature Secondary Structure
MKIKAAVAWKAGAPLSIEEVDLEGPKKGEVLIRVVATGVCHTDAFTLSGADPEGLFPVIL
CCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
GHEGGGIVEEVGEGVTTLKKGDHVIPLYTPECKECKFCLSGKTNLCVRIRATQGKGLMPD
ECCCCCHHHHHCCCHHHHCCCCEEEEEECCCHHHCCEEECCCCCEEEEEEECCCCCCCCC
GTSRFSKDGKMIHHYMGCSTFAEYTVVPEIALAKVNPAAPLDKVCLLGCGVTTGIGAVLN
CCHHHCCCCHHHHHHHCHHHHHHEEECCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHH
TAKVEKGATVAVFGLGGIGLSVIQGAKMAGASRIIAIDINDAKWEMAQKFGATDFVNPKK
HHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCC
HDKPIQQVIVEMTEWGVDYSFECVGNTQLMRAALECAHRGWGQSIVIGVAGAGQEISTRP
CCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRTELPGYVEQYMSGEINIDDMVTFTMPLEDINKAFDYMHEG
EEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHCC
KSIRSVIKM
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]