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The map label for this gene is lepB [H]

Identifier: 42522424

GI number: 42522424

Start: 798977

End: 799765

Strand: Direct

Name: lepB [H]

Synonym: Bd0852

Alternate gene names: 42522424

Gene position: 798977-799765 (Clockwise)

Preceding gene: 42522423

Following gene: 42522425

Centisome position: 21.12

GC content: 49.43

Gene sequence:

>789_bases
ATGAGCGACAAACAACCAAAAAGCTGGGACTTTAGAACGAAACACTTCTGGACAGAGGGTTGGGGCTCTTTGTTCCTGGC
GGTGTTCATCGCTTTGTTCATTCGCTGGGGCTTCATCGAAGCTTACGTGATTCCATCGGGCTCGATGCTGCCGTCGCTTT
TGATTCATGACCATATCTTCGTGAACAAGCTGACTTACGGTCTGCGTGTTCCTTTCAGCGAAAAATGGCTGGTGAAATTC
AACGAACCTGAGCGTGGGGAAGTGATTGTCTTTAAATATCCTAAAGACATGAGCACTTTCTTCATCAAACGCATCGTGGG
CGAGTCGGGCGACAAGGTTTACTACGAAAACGGGACTCTTTATATCAACGACAAACCGGTTGAAAAAAAGGTTCCAGCCA
ACATGGATGACTTTGCATGGCTTCGCGATGCGGACTTCCAGCGTGATGGCAATATCAATGATAGCAAAGAAAACTACGTC
GAGTTCACTGAAGTCCTGCCGGCGGGCAAAGCTGCCAAAGAAGGTAAAGAGCATGCCATCCTTCTTCGCAAGGGTGATAT
CTATGAAACCTTTGGCCCGGTGACCATTCCGGATGACCATCTGTTTGTCATGGGCGACAACCGCATGAATTCTTCAGACA
GCCGTGTGTGGGGTTTCCTGCCAAAACAAAACATCCTGGGTCGTGCGATGTTCGTATGGCTAAGTTGCGAAGAAACGGTG
CCGATGCTTCCGTTCCTGTGCAACCCGCTGACCATCCGCTGGGGACGTTTCTTCCACTCTGTGAACTAG

Upstream 100 bases:

>100_bases
CAAAAAGAGGGTAAGAAGCGCATGAAGGCCATCGGCCATGTCGAAGTCCCTCAAGAAGCCTTCCTCGCGATCCTGAAAGT
CGAAGACTAGGAGAATCAAC

Downstream 100 bases:

>100_bases
ATGTCTGAACCCAAGGCCACTCCCAATCTGAAAGGAACATGGAATCAGGCGATCCTGACTTTCTTGTTTCCGATTCTGCT
GGTGATGGGAGTGCGCTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSDKQPKSWDFRTKHFWTEGWGSLFLAVFIALFIRWGFIEAYVIPSGSMLPSLLIHDHIFVNKLTYGLRVPFSEKWLVKF
NEPERGEVIVFKYPKDMSTFFIKRIVGESGDKVYYENGTLYINDKPVEKKVPANMDDFAWLRDADFQRDGNINDSKENYV
EFTEVLPAGKAAKEGKEHAILLRKGDIYETFGPVTIPDDHLFVMGDNRMNSSDSRVWGFLPKQNILGRAMFVWLSCEETV
PMLPFLCNPLTIRWGRFFHSVN

Sequences:

>Translated_262_residues
MSDKQPKSWDFRTKHFWTEGWGSLFLAVFIALFIRWGFIEAYVIPSGSMLPSLLIHDHIFVNKLTYGLRVPFSEKWLVKF
NEPERGEVIVFKYPKDMSTFFIKRIVGESGDKVYYENGTLYINDKPVEKKVPANMDDFAWLRDADFQRDGNINDSKENYV
EFTEVLPAGKAAKEGKEHAILLRKGDIYETFGPVTIPDDHLFVMGDNRMNSSDSRVWGFLPKQNILGRAMFVWLSCEETV
PMLPFLCNPLTIRWGRFFHSVN
>Mature_261_residues
SDKQPKSWDFRTKHFWTEGWGSLFLAVFIALFIRWGFIEAYVIPSGSMLPSLLIHDHIFVNKLTYGLRVPFSEKWLVKFN
EPERGEVIVFKYPKDMSTFFIKRIVGESGDKVYYENGTLYINDKPVEKKVPANMDDFAWLRDADFQRDGNINDSKENYVE
FTEVLPAGKAAKEGKEHAILLRKGDIYETFGPVTIPDDHLFVMGDNRMNSSDSRVWGFLPKQNILGRAMFVWLSCEETVP
MLPFLCNPLTIRWGRFFHSVN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=257, Percent_Identity=34.2412451361868, Blast_Score=135, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 30454; Mature: 30323

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKQPKSWDFRTKHFWTEGWGSLFLAVFIALFIRWGFIEAYVIPSGSMLPSLLIHDHIF
CCCCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
VNKLTYGLRVPFSEKWLVKFNEPERGEVIVFKYPKDMSTFFIKRIVGESGDKVYYENGTL
EEHEEEEEECCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCEE
YINDKPVEKKVPANMDDFAWLRDADFQRDGNINDSKENYVEFTEVLPAGKAAKEGKEHAI
EECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCEEE
LLRKGDIYETFGPVTIPDDHLFVMGDNRMNSSDSRVWGFLPKQNILGRAMFVWLSCEETV
EEEECCCHHHCCCEECCCCEEEEEECCCCCCCCCEEEECCCCCHHCCEEEEEEEECCCCC
PMLPFLCNPLTIRWGRFFHSVN
CCHHHHCCCEEEEHHHHHCCCC
>Mature Secondary Structure 
SDKQPKSWDFRTKHFWTEGWGSLFLAVFIALFIRWGFIEAYVIPSGSMLPSLLIHDHIF
CCCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
VNKLTYGLRVPFSEKWLVKFNEPERGEVIVFKYPKDMSTFFIKRIVGESGDKVYYENGTL
EEHEEEEEECCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCEE
YINDKPVEKKVPANMDDFAWLRDADFQRDGNINDSKENYVEFTEVLPAGKAAKEGKEHAI
EECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCEEE
LLRKGDIYETFGPVTIPDDHLFVMGDNRMNSSDSRVWGFLPKQNILGRAMFVWLSCEETV
EEEECCCHHHCCCEECCCCEEEEEECCCCCCCCCEEEECCCCCHHCCEEEEEEEECCCCC
PMLPFLCNPLTIRWGRFFHSVN
CCHHHHCCCEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]