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The map label for this gene is lepB [H]

Identifier: 42522425

GI number: 42522425

Start: 799766

End: 800473

Strand: Direct

Name: lepB [H]

Synonym: Bd0853

Alternate gene names: 42522425

Gene position: 799766-800473 (Clockwise)

Preceding gene: 42522424

Following gene: 42522426

Centisome position: 21.14

GC content: 48.87

Gene sequence:

>708_bases
ATGTCTGAACCCAAGGCCACTCCCAATCTGAAAGGAACATGGAATCAGGCGATCCTGACTTTCTTGTTTCCGATTCTGCT
GGTGATGGGAGTGCGCTGGGCCTTGTTTGAGCCCTTCGTGATCCCGTCCGGGAGCATGATTCCGAATCTTCTGATCCATG
ACCACATTCTGGTAAAAAAATTCGCTTACGGTCTGCACATCCCTTTCAGTGACAAGTGGCTGGTGCAATGGTCAACGCCT
GAGCGCGGGGATATCGTGGTTTTCAAGTACCCTGAAAATCCGGATGTCTATTATATCAAGCGTTTGATTGGCCTGCCCGG
GGATCAGATTGAAGTCCGCGCCGGTCGCATTACAGTCAATGGCAAGGCTTTTGAGATGGCTCCTTACGAGGGCCCCCTGG
TGAACAATAAAGAGTTTTATTATTTCACTGAAAACAACACTCAGAAGTCCTACGTGGTGCGCTTCCTCAGTGAAGAAAAC
TCGGCCGATGTGCAGGTCTATCAAGTTCCGCCGGATCAGTTCTTCTTTATGGGTGACAACCGGGACCAATCCAGTGACTC
ACGTTTCTGGGGTTTTGTGAAAAACGACTATCTGGTCGGAAAAGCGTCGGTTATCTGGCTATCTTGTAACAGCACTTTGC
CGACAATGACGTTTGTGTGTGACCCCTCACAAATCCGCTTCAACCGTTTATTTAAGACCTTGGATTAA

Upstream 100 bases:

>100_bases
GTTCGTATGGCTAAGTTGCGAAGAAACGGTGCCGATGCTTCCGTTCCTGTGCAACCCGCTGACCATCCGCTGGGGACGTT
TCTTCCACTCTGTGAACTAG

Downstream 100 bases:

>100_bases
TAGGTCGTCTAAGAAATAATTGAAAGCCCTCAGAATTGCTTTGAAGGTCTCGCCCAAGTCCGTTTAGGATTTAGGGATGA
ATCGTTGGCGGGAATATCTA

Product: hypothetical protein

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSEPKATPNLKGTWNQAILTFLFPILLVMGVRWALFEPFVIPSGSMIPNLLIHDHILVKKFAYGLHIPFSDKWLVQWSTP
ERGDIVVFKYPENPDVYYIKRLIGLPGDQIEVRAGRITVNGKAFEMAPYEGPLVNNKEFYYFTENNTQKSYVVRFLSEEN
SADVQVYQVPPDQFFFMGDNRDQSSDSRFWGFVKNDYLVGKASVIWLSCNSTLPTMTFVCDPSQIRFNRLFKTLD

Sequences:

>Translated_235_residues
MSEPKATPNLKGTWNQAILTFLFPILLVMGVRWALFEPFVIPSGSMIPNLLIHDHILVKKFAYGLHIPFSDKWLVQWSTP
ERGDIVVFKYPENPDVYYIKRLIGLPGDQIEVRAGRITVNGKAFEMAPYEGPLVNNKEFYYFTENNTQKSYVVRFLSEEN
SADVQVYQVPPDQFFFMGDNRDQSSDSRFWGFVKNDYLVGKASVIWLSCNSTLPTMTFVCDPSQIRFNRLFKTLD
>Mature_234_residues
SEPKATPNLKGTWNQAILTFLFPILLVMGVRWALFEPFVIPSGSMIPNLLIHDHILVKKFAYGLHIPFSDKWLVQWSTPE
RGDIVVFKYPENPDVYYIKRLIGLPGDQIEVRAGRITVNGKAFEMAPYEGPLVNNKEFYYFTENNTQKSYVVRFLSEENS
ADVQVYQVPPDQFFFMGDNRDQSSDSRFWGFVKNDYLVGKASVIWLSCNSTLPTMTFVCDPSQIRFNRLFKTLD

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=237, Percent_Identity=41.3502109704641, Blast_Score=146, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 27144; Mature: 27013

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPKATPNLKGTWNQAILTFLFPILLVMGVRWALFEPFVIPSGSMIPNLLIHDHILVKK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCEECCCCCCCCHHHHHHHHHHHH
FAYGLHIPFSDKWLVQWSTPERGDIVVFKYPENPDVYYIKRLIGLPGDQIEVRAGRITVN
HHHEEECCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHHCCCCCEEEEEEEEEEEC
GKAFEMAPYEGPLVNNKEFYYFTENNTQKSYVVRFLSEENSADVQVYQVPPDQFFFMGDN
CCEEEECCCCCCEECCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEECC
RDQSSDSRFWGFVKNDYLVGKASVIWLSCNSTLPTMTFVCDPSQIRFNRLFKTLD
CCCCCCCEEEEEEECCEEEECEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEPKATPNLKGTWNQAILTFLFPILLVMGVRWALFEPFVIPSGSMIPNLLIHDHILVKK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCEECCCCCCCCHHHHHHHHHHHH
FAYGLHIPFSDKWLVQWSTPERGDIVVFKYPENPDVYYIKRLIGLPGDQIEVRAGRITVN
HHHEEECCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHHCCCCCEEEEEEEEEEEC
GKAFEMAPYEGPLVNNKEFYYFTENNTQKSYVVRFLSEENSADVQVYQVPPDQFFFMGDN
CCEEEECCCCCCEECCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEECC
RDQSSDSRFWGFVKNDYLVGKASVIWLSCNSTLPTMTFVCDPSQIRFNRLFKTLD
CCCCCCCEEEEEEECCEEEECEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]