Click here to switch to the map view.

The map label for this gene is ytcI [H]

Identifier: 42522110

GI number: 42522110

Start: 472903

End: 474591

Strand: Direct

Name: ytcI [H]

Synonym: Bd0504

Alternate gene names: 42522110

Gene position: 472903-474591 (Clockwise)

Preceding gene: 42522106

Following gene: 42522111

Centisome position: 12.5

GC content: 51.69

Gene sequence:

>1689_bases
ATGAGTTTTCGTAATGAATTTGAGCAGGCGAGGGATTTTCTGATTCTGCACCGTTCAGACTATAAACATGCTTACAGCCA
ATTCCGCTGGCCCCGTTTTGATGATTTCAACTGGGCTCTGGATTATTTCGACCCCATGGCCGAAGGCAATACCAAGATCG
GTCTGTGGCTGGTGGATGAGCTGGGACATGAAAAGAAGTTCAGCTTCAGCGAAATCTCCAAACGTTCCAATCAGGCGGCG
AACTTTATGCGCGCCCGGGGATTGCAAAAAGGCGACTCTGTCTTTCTGCTGATCGAAGATGACGTGGCCCTTTGGGAAAT
CATGCTGGCGGCCATGAAGCTCGGTGCGGTGATCGTTCCGAACAATCCTTTGTTGTCCCAGCAGGAGCTGAAAGACCGCT
TGAACCGCGAGCAGATCAAGATGATCGCCACAACCAAAGCACACACAGAAAAATTTGATGTGACCTCTTCGGGGGTTATC
CCTGTGGTGGTGGATGCCGAAGTCGAGGGCTGGATTTTTTATCCGGAAGCGTACAAGGAAAGTGCAGAGTTCGAAGCCAC
TGAGCGGACCAAGGCCACGGATCCCCTGTTCCGGTACTTTACTTCTTCCAGCGGGGTGAAACCAAAACTTGTCGAGCACA
GTCATGCCGGATTTACGGTCGGGCATCTTTCCACCATGTACTGGATGGGACTGCATCCCGGGGACGTGCATCTGGGAATC
AACTCTGCCGGCTGGGCCATGCATGACTGGAACTCTTTTGTCGCACCTTGGAATGCCGAGGCGACGGTTTTTGTTTTCAA
GGAAAAGCGTTTCAACGCCAGTTTGATTTTGGATGTTCTGGATGAATATCCCATCACCACCTTCTGTGCGCCGCCGACGG
TGTGGCGTTTGTTGTGCCAGGAAGATCTTAGATCCTATGACGTCCATCTGCGCGAAGCCTTAAGCACCGGAGAGCCACTG
ACGGCAGATCTGATTTCGAAAGTTCATCATGCCTGGGGCCTTTTCATCCGCGATGGATATGGCCAGACCGAGTCTGCAAC
TCTGATCGGGGTGCCGCCAGAAGAAAAAGACAGTTTCGGGACATCCGGAAAAGCCATGCCAGGCTTCAAAATCGCGCTGC
TGGATGCTCAGGGTGAAGAGACCGACAGCGGGGAAATCTGTGTGGATATCTCGGAGAGCCCCTGGGGGCTGATGTCGGGA
CTGGATACTTCGAACAAATACTTTCATACCGGAGACACGGCATATCTGGACAGTATGGGGAACTTTACCTATTGCGACCG
CATCGATGGACTGTTCAAGTCCTCGGACTATCGCATCAGTCCTTTTGAGATTGAATTTGTGTTGAAAGAGTTTCCATCCA
TTCGTGAGGCGGTGGTGATTCCGAGTCCTGATCCCATTCGTGAAAATGTGCCGAAAGCCCTGGTCATGCTGAGCAAAGGT
GTTGAGCCCAGCAAGGAGCTGGCTTTGGATATTATGAATTTTGCACGCATGCGCCTGTCTCCTTTCAAGCGTATTCGCCG
CGTGGAGTTTATGGAAATTCCCAAAAATACGTCTGGAGAAGTGCTCCGCTCGGATTTGGTCAATCTGGAGCGCGAGAAAA
GAAAGCGCGGAGAAAAAGCCCCTTATGAATTCTGGGAAGAAGACGCCAAGATCGTCATCCCTGACACATGGGCGCAAGAA
CTGCCTTGA

Upstream 100 bases:

>100_bases
TTTTATCATGATTGGCTTGTGCTTGCACAGTCCAATGTAGAAACACAGATCGGCGAGTCGATGAACAAATGCTAATCTTG
GAAAGTCGCGGGAGGTTTGT

Downstream 100 bases:

>100_bases
GTTTAGTCTTGTTACAAGACTGAAAGAGTGGGGTCTTCTTGTTCGTTCTTTGTTCATTCGCTGTTATGATTACAGTGTGA
AAACACGGTTATTAATTCTT

Product: acetyl-CoA synthetase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MSFRNEFEQARDFLILHRSDYKHAYSQFRWPRFDDFNWALDYFDPMAEGNTKIGLWLVDELGHEKKFSFSEISKRSNQAA
NFMRARGLQKGDSVFLLIEDDVALWEIMLAAMKLGAVIVPNNPLLSQQELKDRLNREQIKMIATTKAHTEKFDVTSSGVI
PVVVDAEVEGWIFYPEAYKESAEFEATERTKATDPLFRYFTSSSGVKPKLVEHSHAGFTVGHLSTMYWMGLHPGDVHLGI
NSAGWAMHDWNSFVAPWNAEATVFVFKEKRFNASLILDVLDEYPITTFCAPPTVWRLLCQEDLRSYDVHLREALSTGEPL
TADLISKVHHAWGLFIRDGYGQTESATLIGVPPEEKDSFGTSGKAMPGFKIALLDAQGEETDSGEICVDISESPWGLMSG
LDTSNKYFHTGDTAYLDSMGNFTYCDRIDGLFKSSDYRISPFEIEFVLKEFPSIREAVVIPSPDPIRENVPKALVMLSKG
VEPSKELALDIMNFARMRLSPFKRIRRVEFMEIPKNTSGEVLRSDLVNLEREKRKRGEKAPYEFWEEDAKIVIPDTWAQE
LP

Sequences:

>Translated_562_residues
MSFRNEFEQARDFLILHRSDYKHAYSQFRWPRFDDFNWALDYFDPMAEGNTKIGLWLVDELGHEKKFSFSEISKRSNQAA
NFMRARGLQKGDSVFLLIEDDVALWEIMLAAMKLGAVIVPNNPLLSQQELKDRLNREQIKMIATTKAHTEKFDVTSSGVI
PVVVDAEVEGWIFYPEAYKESAEFEATERTKATDPLFRYFTSSSGVKPKLVEHSHAGFTVGHLSTMYWMGLHPGDVHLGI
NSAGWAMHDWNSFVAPWNAEATVFVFKEKRFNASLILDVLDEYPITTFCAPPTVWRLLCQEDLRSYDVHLREALSTGEPL
TADLISKVHHAWGLFIRDGYGQTESATLIGVPPEEKDSFGTSGKAMPGFKIALLDAQGEETDSGEICVDISESPWGLMSG
LDTSNKYFHTGDTAYLDSMGNFTYCDRIDGLFKSSDYRISPFEIEFVLKEFPSIREAVVIPSPDPIRENVPKALVMLSKG
VEPSKELALDIMNFARMRLSPFKRIRRVEFMEIPKNTSGEVLRSDLVNLEREKRKRGEKAPYEFWEEDAKIVIPDTWAQE
LP
>Mature_561_residues
SFRNEFEQARDFLILHRSDYKHAYSQFRWPRFDDFNWALDYFDPMAEGNTKIGLWLVDELGHEKKFSFSEISKRSNQAAN
FMRARGLQKGDSVFLLIEDDVALWEIMLAAMKLGAVIVPNNPLLSQQELKDRLNREQIKMIATTKAHTEKFDVTSSGVIP
VVVDAEVEGWIFYPEAYKESAEFEATERTKATDPLFRYFTSSSGVKPKLVEHSHAGFTVGHLSTMYWMGLHPGDVHLGIN
SAGWAMHDWNSFVAPWNAEATVFVFKEKRFNASLILDVLDEYPITTFCAPPTVWRLLCQEDLRSYDVHLREALSTGEPLT
ADLISKVHHAWGLFIRDGYGQTESATLIGVPPEEKDSFGTSGKAMPGFKIALLDAQGEETDSGEICVDISESPWGLMSGL
DTSNKYFHTGDTAYLDSMGNFTYCDRIDGLFKSSDYRISPFEIEFVLKEFPSIREAVVIPSPDPIRENVPKALVMLSKGV
EPSKELALDIMNFARMRLSPFKRIRRVEFMEIPKNTSGEVLRSDLVNLEREKRKRGEKAPYEFWEEDAKIVIPDTWAQEL
P

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=538, Percent_Identity=31.9702602230483, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38505220, Length=501, Percent_Identity=34.1317365269461, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI122937307, Length=538, Percent_Identity=30.4832713754647, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI58082049, Length=524, Percent_Identity=28.8167938931298, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI157311624, Length=524, Percent_Identity=28.2442748091603, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI157311622, Length=524, Percent_Identity=28.2442748091603, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI115511026, Length=569, Percent_Identity=26.8892794376098, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI42544134, Length=384, Percent_Identity=29.9479166666667, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI195947378, Length=437, Percent_Identity=25.4004576659039, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI13375727, Length=515, Percent_Identity=22.7184466019417, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI28416953, Length=522, Percent_Identity=23.3716475095785, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI8923896, Length=556, Percent_Identity=22.841726618705, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI253970489, Length=569, Percent_Identity=22.6713532513181, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI31982927, Length=514, Percent_Identity=23.1517509727626, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790505, Length=559, Percent_Identity=24.5080500894454, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788107, Length=521, Percent_Identity=23.6084452975048, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI221142682, Length=492, Percent_Identity=23.1707317073171, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786529, Length=551, Percent_Identity=22.5045372050817, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=480, Percent_Identity=23.125, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=272, Percent_Identity=27.2058823529412, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983001, Length=528, Percent_Identity=24.8106060606061, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71982997, Length=528, Percent_Identity=24.8106060606061, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=502, Percent_Identity=21.7131474103586, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71996755, Length=507, Percent_Identity=24.4575936883629, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=514, Percent_Identity=21.9844357976654, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=503, Percent_Identity=23.6580516898608, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=519, Percent_Identity=20.8092485549133, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=278, Percent_Identity=24.1007194244604, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=21.8579234972678, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=540, Percent_Identity=26.1111111111111, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323182, Length=542, Percent_Identity=24.7232472324723, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319699, Length=473, Percent_Identity=23.2558139534884, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24667955, Length=541, Percent_Identity=23.4750462107209, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355181, Length=497, Percent_Identity=24.5472837022133, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472339, Length=541, Percent_Identity=23.4750462107209, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667959, Length=379, Percent_Identity=25.5936675461741, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859661, Length=504, Percent_Identity=24.2063492063492, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21355225, Length=532, Percent_Identity=20.6766917293233, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281365686, Length=325, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 64027; Mature: 63896

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRNEFEQARDFLILHRSDYKHAYSQFRWPRFDDFNWALDYFDPMAEGNTKIGLWLVDE
CCCHHHHHHHHCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHCCHHCCCCCEEEEEEEHH
LGHEKKFSFSEISKRSNQAANFMRARGLQKGDSVFLLIEDDVALWEIMLAAMKLGAVIVP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEEC
NNPLLSQQELKDRLNREQIKMIATTKAHTEKFDVTSSGVIPVVVDAEVEGWIFYPEAYKE
CCCCCCHHHHHHHHCHHHHHEEEECCCCCCEECCCCCCCEEEEEECCCCCEEECCHHHCC
SAEFEATERTKATDPLFRYFTSSSGVKPKLVEHSHAGFTVGHLSTMYWMGLHPGDVHLGI
CCCCCHHHCCCCCCHHHHHHHCCCCCCCHHCCCCCCCEEHHHHHHHHEECCCCCCEEEEC
NSAGWAMHDWNSFVAPWNAEATVFVFKEKRFNASLILDVLDEYPITTFCAPPTVWRLLCQ
CCCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
EDLRSYDVHLREALSTGEPLTADLISKVHHAWGLFIRDGYGQTESATLIGVPPEEKDSFG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCCCCC
TSGKAMPGFKIALLDAQGEETDSGEICVDISESPWGLMSGLDTSNKYFHTGDTAYLDSMG
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCCEEECCCCHHHHCCC
NFTYCDRIDGLFKSSDYRISPFEIEFVLKEFPSIREAVVIPSPDPIRENVPKALVMLSKG
CEEHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCC
VEPSKELALDIMNFARMRLSPFKRIRRVEFMEIPKNTSGEVLRSDLVNLEREKRKRGEKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
PYEFWEEDAKIVIPDTWAQELP
CHHHHCCCCEEEECCCHHHHCC
>Mature Secondary Structure 
SFRNEFEQARDFLILHRSDYKHAYSQFRWPRFDDFNWALDYFDPMAEGNTKIGLWLVDE
CCHHHHHHHHCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHCCHHCCCCCEEEEEEEHH
LGHEKKFSFSEISKRSNQAANFMRARGLQKGDSVFLLIEDDVALWEIMLAAMKLGAVIVP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEEC
NNPLLSQQELKDRLNREQIKMIATTKAHTEKFDVTSSGVIPVVVDAEVEGWIFYPEAYKE
CCCCCCHHHHHHHHCHHHHHEEEECCCCCCEECCCCCCCEEEEEECCCCCEEECCHHHCC
SAEFEATERTKATDPLFRYFTSSSGVKPKLVEHSHAGFTVGHLSTMYWMGLHPGDVHLGI
CCCCCHHHCCCCCCHHHHHHHCCCCCCCHHCCCCCCCEEHHHHHHHHEECCCCCCEEEEC
NSAGWAMHDWNSFVAPWNAEATVFVFKEKRFNASLILDVLDEYPITTFCAPPTVWRLLCQ
CCCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
EDLRSYDVHLREALSTGEPLTADLISKVHHAWGLFIRDGYGQTESATLIGVPPEEKDSFG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCCCCC
TSGKAMPGFKIALLDAQGEETDSGEICVDISESPWGLMSGLDTSNKYFHTGDTAYLDSMG
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCCEEECCCCHHHHCCC
NFTYCDRIDGLFKSSDYRISPFEIEFVLKEFPSIREAVVIPSPDPIRENVPKALVMLSKG
CEEHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCC
VEPSKELALDIMNFARMRLSPFKRIRRVEFMEIPKNTSGEVLRSDLVNLEREKRKRGEKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
PYEFWEEDAKIVIPDTWAQELP
CHHHHCCCCEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]