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The map label for this gene is hoxN1

Identifier: 38637691

GI number: 38637691

Start: 21335

End: 22390

Strand: Direct

Name: hoxN1

Synonym: PHG023

Alternate gene names: 38637691

Gene position: 21335-22390 (Clockwise)

Preceding gene: 38637690

Following gene: 38637692

Centisome position: 4.72

GC content: 58.71

Gene sequence:

>1056_bases
ATGTTCCAATTGCTCGCTGGCGTACGCATGAATTCTACTGGCCGCCCGCGGGCCAAGATCATCTTGCTCTACGCGCTGCT
GATTGCATTCAATATCGGCGCCTGGCTCTGCGCGCTCGCCGCGTTTCGCGATCATCCGGTGCTGCTCGGCACCGCACTGC
TGGCCTACGGCCTTGGGTTGCGCCACGCGGTAGACGCAGATCATCTCGCGGCAATCGACAATGTCACCCGCAAGTTGATG
CAGGACGGCAGGCGGCCCATCACAGCTGGGCTTTGGTTCTCGCTTGGCCATTCAAGTGTGGTAGTGCTTGCTTCGGTGCT
GATCGCTGTCATGGCGACCACGCTCCAGGAGCGTCTGGACGCGTTTCATGAAGTCGGCAGCGTTATCGGCACGCTTGCTT
CCGCGCTATTTTTGTTCGCCATTGCGGCGATCAATCTGGTGATCCTGCGCTCGGCGTATCGGGCGTTCCGGCGTGTGCGG
CGCGGCGGCATCTACGTTGAGGAAGACTTTGACCTTCTGTTCGGCAACCGTGGGTTCCTGGCGCGTATCTTCCGTCCCCT
GTTCCGGTTCATCACACGCAGTTGGCATATGTACCCGCTCGGCATGCTCTTTGCGCTCGGGTTCGATACCGCGACCGAGG
TCGCCTTGCTCGGCATCTCGACGATGGAGGCTTCGCGTGGCGTTCCGATTTGGTCGATTCTGGTATTTCCGGCGCTGTTC
ACCGCCGGCATGGCGCTGATCGACACCATCGATAGCATCCTGATGTGTGGCGCCTATGCGTGGGCCTATGCCAAGCCCGT
GCGCAAGCTCTATTACAACATGACAATTACCTTCGTATCGGCGATTGTTGCCCTCATCGTCGGTGGCATTGAGACGCTTG
GCCTCCTGGCCGACAAGTTCATGTTGAAGGGCGTTTTCTGGAACGCGGTTGGCGCTTTGAACGAGAATTTCTGTCAATTG
GGCTTCGTCATTATTGGCATCTTTACCGTGTGTTGGGTCGTGTCGATCGTCGTCTATCGCTTGCGCCGCTACGACGACAG
CGAAGTGCGTGCCTGA

Upstream 100 bases:

>100_bases
TGGCTCGCAGGCGCGGAAATTGCGTTACGGTGCAGTCGAGCCTTACTGGCAAAAGCCGCGGATGACAGCGGCGTCGGAAC
CGAGACAGGAGACTTCCAGC

Downstream 100 bases:

>100_bases
GGGCCCGCCAAGCTGTCCCAATAGTCCCCACCGGGCGCGCCGGCTCGCAAAACGTGAAACGTCCACGGCCAGGGAAGCGC
TTCCTGGCAGATAGGAAGGC

Product: high-affinity nickel permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGLRHAVDADHLAAIDNVTRKLM
QDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLDAFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVR
RGGIYVEEDFDLLFGNRGFLARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALF
TAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKFMLKGVFWNAVGALNENFCQL
GFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA

Sequences:

>Translated_351_residues
MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGLRHAVDADHLAAIDNVTRKLM
QDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLDAFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVR
RGGIYVEEDFDLLFGNRGFLARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALF
TAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKFMLKGVFWNAVGALNENFCQL
GFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA
>Mature_351_residues
MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGLRHAVDADHLAAIDNVTRKLM
QDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLDAFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVR
RGGIYVEEDFDLLFGNRGFLARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALF
TAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKFMLKGVFWNAVGALNENFCQL
GFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA

Specific function: High-affinity nickel transporter responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease

COG id: COG3376

COG function: function code P; High-affinity nickel permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NiCoT transporter (TC 2.A.52) family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOXN_CUPNH (P23516)

Other databases:

- EMBL:   AF261712
- EMBL:   AY305378
- PIR:   A39512
- RefSeq:   NP_942665.1
- GeneID:   2656444
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG023
- HOGENOM:   HBG322888
- OMA:   SWHMYLV
- ProtClustDB:   CLSK923801
- BioCyc:   REUT381666:PHG023-MONOMER
- InterPro:   IPR004688
- InterPro:   IPR011541
- TIGRFAMs:   TIGR00802

Pfam domain/function: PF03824 NicO

EC number: NA

Molecular weight: Translated: 38772; Mature: 38772

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb651ed0)-; HASH(0xaf49020)-; HASH(0xb7981a4)-; HASH(0xac26740)-; HASH(0xaefab54)-; HASH(0xb741674)-; HASH(0xaf48e40)-; HASH(0xaf447fc)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGL
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
RHAVDADHLAAIDNVTRKLMQDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLD
HHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVRRGGIYVEEDFDLLFGNRGFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCCCHHH
ARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKGVFWNAVGALNENFCQLGFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCH
>Mature Secondary Structure
MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGL
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
RHAVDADHLAAIDNVTRKLMQDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLD
HHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVRRGGIYVEEDFDLLFGNRGFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCCCHHH
ARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKGVFWNAVGALNENFCQLGFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1847142; 7896709; 12948488; 7934894