Click here to switch to the map view.

The map label for this gene is fbp2 [H]

Identifier: 38637692

GI number: 38637692

Start: 25947

End: 26612

Strand: Direct

Name: fbp2 [H]

Synonym: PHG027

Alternate gene names: 38637692

Gene position: 25947-26612 (Clockwise)

Preceding gene: 38637691

Following gene: 38637693

Centisome position: 5.74

GC content: 62.91

Gene sequence:

>666_bases
ATGATTCCGATGACTCAGAAATTGACCTTCACCCGATTTGTCATCGCCGAGCAGCATGGCTCGAAGACCGTTGATTCCGA
TCTGATCGCGCTGTTGCTCGACGTCTCCATTGCTTGCCGGAAGATCGCCAGCTCGATCGCCAAGGGCTCGCCGCTGGCGC
TGGGTGGCGAAGCGGCAGGACGGGACGTACCCGGGGAAATCCAGAGCAAGACCGACATGGCCACCCCCTGTTTCTTCGCG
CGCTCGGAAGCGCTCGCCCGGCACTTGGCCGGAATGGCGTCGGAAGGCATGGAAGGGGCCTATCCGGTGCCGCTCCGCTC
GCCCCAGGGCAGGTACCTGCTGGTTTGCGATCCGCTCGACGGCTCGGCCAACATTGACGTGAACGTCTCTGGGGGGATCA
TCTTCTCAGTCCTGCGTTGCCCAGAAGGCATATCGGCGCCTGAGGAGCGCGACCTCCTCCAAGCGGGTAGCGCGCAGATG
GCCGCGGGATACGCACTGTACGACGCGCCCGCGCTGCTGGTCCTGAAGACCGGCAGCGGGATCCATGGATTTACGCTCGA
CGCGGATTCTGGCCAATACGTGCTAACCCACCCGAACGCGAAGATCCCGCAGGTACCTGCTGGTTCGCGATCTGCGCTTC
GGCCAAGTACTTCTGGGCAGTCTTGA

Upstream 100 bases:

>100_bases
TATCAGTCTGAACACACCAATTCACGCGGCTTGTTCAGCATAGCCTTAGTCGCCAGCCGTACTCCGTAGAAGACCAACTT
GCCTCAAGCAATCTTTGGAG

Downstream 100 bases:

>100_bases
AGGAGGCTCAATGATTCAGTGTGCATTCAAGATTGTGATGAAAGCCGTAGGGAAGAATTGCGCATCGGGTCAAAGGCCGG
GTTGTCGTGACGCTCCCCAG

Product: fructose-1,6-bisphosphate

Products: NA

Alternate protein names: FBPase class 1 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2 [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MIPMTQKLTFTRFVIAEQHGSKTVDSDLIALLLDVSIACRKIASSIAKGSPLALGGEAAGRDVPGEIQSKTDMATPCFFA
RSEALARHLAGMASEGMEGAYPVPLRSPQGRYLLVCDPLDGSANIDVNVSGGIIFSVLRCPEGISAPEERDLLQAGSAQM
AAGYALYDAPALLVLKTGSGIHGFTLDADSGQYVLTHPNAKIPQVPAGSRSALRPSTSGQS

Sequences:

>Translated_221_residues
MIPMTQKLTFTRFVIAEQHGSKTVDSDLIALLLDVSIACRKIASSIAKGSPLALGGEAAGRDVPGEIQSKTDMATPCFFA
RSEALARHLAGMASEGMEGAYPVPLRSPQGRYLLVCDPLDGSANIDVNVSGGIIFSVLRCPEGISAPEERDLLQAGSAQM
AAGYALYDAPALLVLKTGSGIHGFTLDADSGQYVLTHPNAKIPQVPAGSRSALRPSTSGQS
>Mature_221_residues
MIPMTQKLTFTRFVIAEQHGSKTVDSDLIALLLDVSIACRKIASSIAKGSPLALGGEAAGRDVPGEIQSKTDMATPCFFA
RSEALARHLAGMASEGMEGAYPVPLRSPQGRYLLVCDPLDGSANIDVNVSGGIIFSVLRCPEGISAPEERDLLQAGSAQM
AAGYALYDAPALLVLKTGSGIHGFTLDADSGQYVLTHPNAKIPQVPAGSRSALRPSTSGQS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI22907028, Length=193, Percent_Identity=33.160621761658, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI189083692, Length=187, Percent_Identity=33.6898395721925, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI16579888, Length=187, Percent_Identity=33.6898395721925, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1790679, Length=197, Percent_Identity=34.5177664974619, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17508131, Length=200, Percent_Identity=35, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323409, Length=200, Percent_Identity=33.5, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45550998, Length=200, Percent_Identity=37, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921562, Length=200, Percent_Identity=37, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 23012; Mature: 23012

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPMTQKLTFTRFVIAEQHGSKTVDSDLIALLLDVSIACRKIASSIAKGSPLALGGEAAG
CCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
RDVPGEIQSKTDMATPCFFARSEALARHLAGMASEGMEGAYPVPLRSPQGRYLLVCDPLD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCC
GSANIDVNVSGGIIFSVLRCPEGISAPEERDLLQAGSAQMAAGYALYDAPALLVLKTGSG
CCCEEEEEECCHHEEHEECCCCCCCCCCHHHHHHCCCCHHHCCEEEECCCEEEEEECCCC
IHGFTLDADSGQYVLTHPNAKIPQVPAGSRSALRPSTSGQS
CCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIPMTQKLTFTRFVIAEQHGSKTVDSDLIALLLDVSIACRKIASSIAKGSPLALGGEAAG
CCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
RDVPGEIQSKTDMATPCFFARSEALARHLAGMASEGMEGAYPVPLRSPQGRYLLVCDPLD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCC
GSANIDVNVSGGIIFSVLRCPEGISAPEERDLLQAGSAQMAAGYALYDAPALLVLKTGSG
CCCEEEEEECCHHEEHEECCCCCCCCCCHHHHHHCCCCHHHCCEEEECCCEEEEEECCCC
IHGFTLDADSGQYVLTHPNAKIPQVPAGSRSALRPSTSGQS
CCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7767230; 2559876 [H]