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The map label for this gene is hoxA

Identifier: 38637687

GI number: 38637687

Start: 15478

End: 16926

Strand: Direct

Name: hoxA

Synonym: PHG019

Alternate gene names: 38637687

Gene position: 15478-16926 (Clockwise)

Preceding gene: 38637686

Following gene: 38637688

Centisome position: 3.42

GC content: 62.04

Gene sequence:

>1449_bases
ATGTCTGACAAGCAGGCCACTGTTCTTGTCGTCGACGACGAAACCCGTTCACAGGATGCTCTCCGGCGCACTCTTGACGA
GGAATTCCGTGTACTGACGGTCAGCTCCGCCGACGAGGCACGCGCCTTGTTGCTGCGCCAGCCGGTCTCGGTGATCCTGT
GCGATCAACGCATGCCAGGCCTCACGGGGGTGGAATTTCTCAAAGAGGTGCGCGAGCGCTGGCCGGAAATCGTGCGTATC
GTCATCTCAGGCTATACCGATTCGGAAGACATCATTGCAGGGGTTAACGAGGCGGGTATCTATCAGTACATCCTCAAGCC
CTGGGTACCGGACCATTTGATCGACACCGTGCGCCAGGCAGTCGAGGCACAGGGGCTGCAGGGCGATATGCATCGCCTTG
ATCTCGAGTTGCGCACCAGCACGCCGGTCTTGCGCCAGCGAAGCAGCCAGAAACTGGCAAGTGCGCAGAGCGCATTCAAT
TTCGAGCGCATTGTGCGCGCACCGGGCAGCCCATTGGATGCCGTTTGCGAGGTCGCCGCCCGCGTGGCGCGTTATGATTT
GCCGGTTATGGTGCTCGGCGAGTCCGGCACCGGCAAGGAGTTGCTGGCGCGCGCCATTCATTACGCCAGCCCACGCGCGG
CGCGCGCCTTTGTCAGCGAGAACTGCGCTGCCGTGCCGGACAACCTGCTCGAATCCGAGTTGTTCGGGCACAAGCGCGGC
GCCTTCACCGGGGCGTACGAAGATCATGCCGGTCTGTTCCAGCGCGCGAACGGCGGTACCATTTTTCTGGATGAGATTGG
CGATACTTCGCCGGCGTTTCAGGTCAAGCTTCTGCGCGTGCTGCAGGAGGGGGAGGTGCGGCCAGTTGGCTCGCCACGTT
GGATACCGGTCGATGTCCGTGTCATCGCGGCCACCCACTGTAACCTGGAAAGCGACGTCCATGCCGGACGGTTCCGCGAG
GATCTTTATTACCGGATCGCTGGCGTCACCATTTCGATGCCGCCGTTACGGGAGCGTAGTGGGGATTTGCAGCCCATCGC
GGCCAAGCTGCTGGAGCAGGTGGCGCAGGAGCTGGCCCGCCCCGGTCTGTATTTCGGTGGGGACGCACTTGCAGCGATGA
TGGCGTATCCCTGGCCGGGCAACATCCGCGAACTGCGCAATGAGATTTATCGGGCGGTAGCGCTCTCCTCGGGCGAAGAG
ATTCGCGCGCAACTTTTCTCGCGCAAGGTGCTGCACGGTCAGCCCGGCACCGTCAAGCGTGGGCCGCATGTGCAGACTTT
CCCGCAGTCGGGTACGCTGCAGGAGCGACTTGACGCGATCGAGGCGGTGGTGCTGAAGGAGGCGCTCCTGCGCCATCGTT
GGAACAAGACCCATGCGGCCAAGGAGTTGGGTCTATCGCGCGTCGGATTACGTCAGAAGCTGTTGCGCTTTGGCTTGGAG
GAGAAATGA

Upstream 100 bases:

>100_bases
ACCCCATGCACATACGCCTCGCCACCTTGCCATGCACCGGGGTGGCAGCCTGCCGGCGGCACAAGAGTTGCAGGCACTTG
CGGGGAAACGATCTTGAGCC

Downstream 100 bases:

>100_bases
ACGCGCCTGTATGTACCGGTCTTGCCTCAGCAAAACCCGGCGTATTGAATGTGCTCTGGATACAGTCCGGCGGCTGCGGT
GGCTGCAGCATGTCCCTGCT

Product: HoxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSDKQATVLVVDDETRSQDALRRTLDEEFRVLTVSSADEARALLLRQPVSVILCDQRMPGLTGVEFLKEVRERWPEIVRI
VISGYTDSEDIIAGVNEAGIYQYILKPWVPDHLIDTVRQAVEAQGLQGDMHRLDLELRTSTPVLRQRSSQKLASAQSAFN
FERIVRAPGSPLDAVCEVAARVARYDLPVMVLGESGTGKELLARAIHYASPRAARAFVSENCAAVPDNLLESELFGHKRG
AFTGAYEDHAGLFQRANGGTIFLDEIGDTSPAFQVKLLRVLQEGEVRPVGSPRWIPVDVRVIAATHCNLESDVHAGRFRE
DLYYRIAGVTISMPPLRERSGDLQPIAAKLLEQVAQELARPGLYFGGDALAAMMAYPWPGNIRELRNEIYRAVALSSGEE
IRAQLFSRKVLHGQPGTVKRGPHVQTFPQSGTLQERLDAIEAVVLKEALLRHRWNKTHAAKELGLSRVGLRQKLLRFGLE
EK

Sequences:

>Translated_482_residues
MSDKQATVLVVDDETRSQDALRRTLDEEFRVLTVSSADEARALLLRQPVSVILCDQRMPGLTGVEFLKEVRERWPEIVRI
VISGYTDSEDIIAGVNEAGIYQYILKPWVPDHLIDTVRQAVEAQGLQGDMHRLDLELRTSTPVLRQRSSQKLASAQSAFN
FERIVRAPGSPLDAVCEVAARVARYDLPVMVLGESGTGKELLARAIHYASPRAARAFVSENCAAVPDNLLESELFGHKRG
AFTGAYEDHAGLFQRANGGTIFLDEIGDTSPAFQVKLLRVLQEGEVRPVGSPRWIPVDVRVIAATHCNLESDVHAGRFRE
DLYYRIAGVTISMPPLRERSGDLQPIAAKLLEQVAQELARPGLYFGGDALAAMMAYPWPGNIRELRNEIYRAVALSSGEE
IRAQLFSRKVLHGQPGTVKRGPHVQTFPQSGTLQERLDAIEAVVLKEALLRHRWNKTHAAKELGLSRVGLRQKLLRFGLE
EK
>Mature_481_residues
SDKQATVLVVDDETRSQDALRRTLDEEFRVLTVSSADEARALLLRQPVSVILCDQRMPGLTGVEFLKEVRERWPEIVRIV
ISGYTDSEDIIAGVNEAGIYQYILKPWVPDHLIDTVRQAVEAQGLQGDMHRLDLELRTSTPVLRQRSSQKLASAQSAFNF
ERIVRAPGSPLDAVCEVAARVARYDLPVMVLGESGTGKELLARAIHYASPRAARAFVSENCAAVPDNLLESELFGHKRGA
FTGAYEDHAGLFQRANGGTIFLDEIGDTSPAFQVKLLRVLQEGEVRPVGSPRWIPVDVRVIAATHCNLESDVHAGRFRED
LYYRIAGVTISMPPLRERSGDLQPIAAKLLEQVAQELARPGLYFGGDALAAMMAYPWPGNIRELRNEIYRAVALSSGEEI
RAQLFSRKVLHGQPGTVKRGPHVQTFPQSGTLQERLDAIEAVVLKEALLRHRWNKTHAAKELGLSRVGLRQKLLRFGLEE
K

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain

Homologues:

Organism=Escherichia coli, GI1788550, Length=479, Percent_Identity=37.160751565762, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1790437, Length=477, Percent_Identity=38.1551362683438, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788905, Length=481, Percent_Identity=36.3825363825364, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1790299, Length=492, Percent_Identity=33.5365853658537, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI87082152, Length=309, Percent_Identity=43.6893203883495, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87082117, Length=228, Percent_Identity=49.1228070175439, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1787583, Length=359, Percent_Identity=37.883008356546, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789233, Length=350, Percent_Identity=39.1428571428571, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1789087, Length=303, Percent_Identity=42.5742574257426, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786524, Length=307, Percent_Identity=41.3680781758958, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87081872, Length=221, Percent_Identity=46.1538461538462, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789828, Length=416, Percent_Identity=30.2884615384615, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI87081858, Length=217, Percent_Identity=35.4838709677419, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOXA_CUPNH (P29267)

Other databases:

- EMBL:   M64593
- EMBL:   AY305378
- PIR:   A38533
- RefSeq:   NP_942661.1
- ProteinModelPortal:   P29267
- SMR:   P29267
- GeneID:   2656440
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG019
- eggNOG:   COG2204
- HOGENOM:   HBG740884
- OMA:   NEIYRAV
- PhylomeDB:   P29267
- ProtClustDB:   CLSK911647
- BioCyc:   REUT381666:PHG019-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789
- PRINTS:   PR01590
- SMART:   SM00382
- SMART:   SM00448

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat; SSF52172 CheY_like; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 53588; Mature: 53457

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50110 RESPONSE_REGULATORY; PS00675 SIGMA54_INTERACT_1; PS00676 SIGMA54_INTERACT_2; PS00688 SIGMA54_INTERACT_3; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKQATVLVVDDETRSQDALRRTLDEEFRVLTVSSADEARALLLRQPVSVILCDQRMPG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCEEEECCCCCC
LTGVEFLKEVRERWPEIVRIVISGYTDSEDIIAGVNEAGIYQYILKPWVPDHLIDTVRQA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
VEAQGLQGDMHRLDLELRTSTPVLRQRSSQKLASAQSAFNFERIVRAPGSPLDAVCEVAA
HHHCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RVARYDLPVMVLGESGTGKELLARAIHYASPRAARAFVSENCAAVPDNLLESELFGHKRG
HHHHCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
AFTGAYEDHAGLFQRANGGTIFLDEIGDTSPAFQVKLLRVLQEGEVRPVGSPRWIPVDVR
CCCCCCHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
VIAATHCNLESDVHAGRFREDLYYRIAGVTISMPPLRERSGDLQPIAAKLLEQVAQELAR
EEEEECCCCCCCCCHHHHHHHHHHEEECCEEECCCCHHCCCCCCHHHHHHHHHHHHHHHC
PGLYFGGDALAAMMAYPWPGNIRELRNEIYRAVALSSGEEIRAQLFSRKVLHGQPGTVKR
CCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
GPHVQTFPQSGTLQERLDAIEAVVLKEALLRHRWNKTHAAKELGLSRVGLRQKLLRFGLE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCC
EK
CC
>Mature Secondary Structure 
SDKQATVLVVDDETRSQDALRRTLDEEFRVLTVSSADEARALLLRQPVSVILCDQRMPG
CCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCEEEECCCCCC
LTGVEFLKEVRERWPEIVRIVISGYTDSEDIIAGVNEAGIYQYILKPWVPDHLIDTVRQA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
VEAQGLQGDMHRLDLELRTSTPVLRQRSSQKLASAQSAFNFERIVRAPGSPLDAVCEVAA
HHHCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RVARYDLPVMVLGESGTGKELLARAIHYASPRAARAFVSENCAAVPDNLLESELFGHKRG
HHHHCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
AFTGAYEDHAGLFQRANGGTIFLDEIGDTSPAFQVKLLRVLQEGEVRPVGSPRWIPVDVR
CCCCCCHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEE
VIAATHCNLESDVHAGRFREDLYYRIAGVTISMPPLRERSGDLQPIAAKLLEQVAQELAR
EEEEECCCCCCCCCHHHHHHHHHHEEECCEEECCCCHHCCCCCCHHHHHHHHHHHHHHHC
PGLYFGGDALAAMMAYPWPGNIRELRNEIYRAVALSSGEEIRAQLFSRKVLHGQPGTVKR
CCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
GPHVQTFPQSGTLQERLDAIEAVVLKEALLRHRWNKTHAAKELGLSRVGLRQKLLRFGLE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCC
EK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488