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The map label for this gene is pilC [H]

Identifier: 37680964

GI number: 37680964

Start: 2835841

End: 2837067

Strand: Direct

Name: pilC [H]

Synonym: VV2780

Alternate gene names: 37680964

Gene position: 2835841-2837067 (Clockwise)

Preceding gene: 37680963

Following gene: 37680965

Centisome position: 84.54

GC content: 45.97

Gene sequence:

>1227_bases
ATGAAGCTTAAAACCCATTCACAAATCAAAAACTATCAATGGAAAGGGATTAACGGAGCTGGAAAAAAAGTCTCCGGCAA
CACGCTGGCGCTCACCGAGCTTGAGGTGCGTGATAAGCTGAAAATGCAGCATATCCAGATCAAAAAGATCAAGAAATCCA
GTGTGTCAGTTTTCACGAGGTTAAGCCATAAAGTCAAAGGCAAAGACATCACACTGCTTACCCGCCAACTCTCCACCATG
CTGACCACTGGTGTCCCTATTCTCCAATCACTTAAATTGGTTGCTGACAACCATCGCAAAGCCGAGATGAAGTCGATTTT
AGCCAATGTGAGCAAAGCCGTTGAAGCGGGCACGCCGTTATCCAAAGCGCTTCGCAGTGCCAGCCCACAATTCGATGGCA
TTTATGTTGACTTAGTCGCCACTGGTGAACAATCGGGTAATCTTGATCAAGTTTTTGAACGCCTCGCTTTTTATCGAGAA
AAAAATGAGCAGTTGCGAGCAAAAGTAATCAAGGCGCTGATTTATCCCTGCATGGTCGTGCTGGTCGCGTTGGGGGTCTC
TTATTTAATGCTGACTCAGGTTATTCCCGAGTTTCGCAAAATGTTCACCGGATTCGGCGCAGAACTGCCTTGGTTTACGC
AAAAAGTCTTAGACCTGTCTGATTTTGTGCAAGCCTACAGCAGTTGGTTTTTCATTACGTTGTTCAGCGCTATCTATTTA
CTTCGCGGTCTAAGCAAAAAATCACCCGCATTTCGCTTAAAAATGTCACGCTTGAGTTTAAAGATTCCTGTGATTGGTGG
GGTCTTATCCAAAGCGGCGATTGCCAAATTTAGCCGCACATTGGCCACCAGTTTCAGTGCAGGTATCCCGATCCTCACCA
GTTTAAAAACCACCAGTAAAACCGCTGGCAATCTGCATTACCAATATGCGATTGAAGATGTTTATCGTGACACCGCAGCC
GGGATGCCAATGTACATCGCCATGCGCAACAGCCTTGCTTTCCCAGAATTGGTGCTGCAAATGGTGATGATTGGTGAAGA
ATCTGGCCAAATGGACGATATGCTCAACAAAATTGCCACCATCTATGAGTTTGAAGTGGATAACACCGTCGACAACCTCG
GTAAAATTCTCGAGCCGTTGATCATCGTCTTTCTGGGCGTTGTCGTCGGCGGATTGGTCACCGCAATGTACTTGCCGATC
TTTAATTTAATGAGTGTTCTGGGATAA

Upstream 100 bases:

>100_bases
TCAAACAGGGCATCACCAGCTTAGAAGAGCTGCAACGCGTCCTCTATTTGTAATTTTTATAGTTTGTTTTTTCGATACTC
ATCGCACTGAAGGAAGCGAT

Downstream 100 bases:

>100_bases
GATAACCCTCGCAGTTTACCTTTTGTAATATCAAGCAAGCTATTGGCTTGCTTGAGCTATTTTTGCCCACACCACAAAGA
GAACGACGATTATATGGACG

Product: type IV pilus (Tfp) assembly protein PilC

Products: NA

Alternate protein names: Type IV-A pilus assembly protein pilC [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKLKTHSQIKNYQWKGINGAGKKVSGNTLALTELEVRDKLKMQHIQIKKIKKSSVSVFTRLSHKVKGKDITLLTRQLSTM
LTTGVPILQSLKLVADNHRKAEMKSILANVSKAVEAGTPLSKALRSASPQFDGIYVDLVATGEQSGNLDQVFERLAFYRE
KNEQLRAKVIKALIYPCMVVLVALGVSYLMLTQVIPEFRKMFTGFGAELPWFTQKVLDLSDFVQAYSSWFFITLFSAIYL
LRGLSKKSPAFRLKMSRLSLKIPVIGGVLSKAAIAKFSRTLATSFSAGIPILTSLKTTSKTAGNLHYQYAIEDVYRDTAA
GMPMYIAMRNSLAFPELVLQMVMIGEESGQMDDMLNKIATIYEFEVDNTVDNLGKILEPLIIVFLGVVVGGLVTAMYLPI
FNLMSVLG

Sequences:

>Translated_408_residues
MKLKTHSQIKNYQWKGINGAGKKVSGNTLALTELEVRDKLKMQHIQIKKIKKSSVSVFTRLSHKVKGKDITLLTRQLSTM
LTTGVPILQSLKLVADNHRKAEMKSILANVSKAVEAGTPLSKALRSASPQFDGIYVDLVATGEQSGNLDQVFERLAFYRE
KNEQLRAKVIKALIYPCMVVLVALGVSYLMLTQVIPEFRKMFTGFGAELPWFTQKVLDLSDFVQAYSSWFFITLFSAIYL
LRGLSKKSPAFRLKMSRLSLKIPVIGGVLSKAAIAKFSRTLATSFSAGIPILTSLKTTSKTAGNLHYQYAIEDVYRDTAA
GMPMYIAMRNSLAFPELVLQMVMIGEESGQMDDMLNKIATIYEFEVDNTVDNLGKILEPLIIVFLGVVVGGLVTAMYLPI
FNLMSVLG
>Mature_408_residues
MKLKTHSQIKNYQWKGINGAGKKVSGNTLALTELEVRDKLKMQHIQIKKIKKSSVSVFTRLSHKVKGKDITLLTRQLSTM
LTTGVPILQSLKLVADNHRKAEMKSILANVSKAVEAGTPLSKALRSASPQFDGIYVDLVATGEQSGNLDQVFERLAFYRE
KNEQLRAKVIKALIYPCMVVLVALGVSYLMLTQVIPEFRKMFTGFGAELPWFTQKVLDLSDFVQAYSSWFFITLFSAIYL
LRGLSKKSPAFRLKMSRLSLKIPVIGGVLSKAAIAKFSRTLATSFSAGIPILTSLKTTSKTAGNLHYQYAIEDVYRDTAA
GMPMYIAMRNSLAFPELVLQMVMIGEESGQMDDMLNKIATIYEFEVDNTVDNLGKILEPLIIVFLGVVVGGLVTAMYLPI
FNLMSVLG

Specific function: Involved in the translocation of the type IV pilin [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

Organism=Escherichia coli, GI1789724, Length=403, Percent_Identity=28.287841191067, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786295, Length=392, Percent_Identity=29.3367346938776, Blast_Score=174, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003004
- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 45270; Mature: 45270

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS00874 T2SP_F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKTHSQIKNYQWKGINGAGKKVSGNTLALTELEVRDKLKMQHIQIKKIKKSSVSVFTR
CCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHKVKGKDITLLTRQLSTMLTTGVPILQSLKLVADNHRKAEMKSILANVSKAVEAGTPL
HHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCH
SKALRSASPQFDGIYVDLVATGEQSGNLDQVFERLAFYREKNEQLRAKVIKALIYPCMVV
HHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVALGVSYLMLTQVIPEFRKMFTGFGAELPWFTQKVLDLSDFVQAYSSWFFITLFSAIYL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGLSKKSPAFRLKMSRLSLKIPVIGGVLSKAAIAKFSRTLATSFSAGIPILTSLKTTSK
HHCCCCCCCHHEEEHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC
TAGNLHYQYAIEDVYRDTAAGMPMYIAMRNSLAFPELVLQMVMIGEESGQMDDMLNKIAT
CCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
IYEFEVDNTVDNLGKILEPLIIVFLGVVVGGLVTAMYLPIFNLMSVLG
HHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure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HHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10024587; 10952301 [H]