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The map label for this gene is vvpD [H]

Identifier: 37680965

GI number: 37680965

Start: 2837110

End: 2838030

Strand: Direct

Name: vvpD [H]

Synonym: VV2781

Alternate gene names: 37680965

Gene position: 2837110-2838030 (Clockwise)

Preceding gene: 37680964

Following gene: 37680966

Centisome position: 84.58

GC content: 47.88

Gene sequence:

>921_bases
TTGGCTTGCTTGAGCTATTTTTGCCCACACCACAAAGAGAACGACGATTATATGGACGCGTTACAATACTACCCTTGGCT
TTATATTGGTTTAGCTTCCCTGTTTGGCTTACTGGTAGGCAGCTTTCTTAACGTCGTCATCTACCGTCTGCCGAAAATAA
TGGAACTGGAATGGCGCCAAGAGTGTGCAGAGTCCTTTCCTGAATACAACATCACACCACCGACAGAAACCCTAACATTA
AGCACGCCGCGCTCAAGTTGCCCTTCGTGCCATACCCCAATACGAGTTCGAGATAATATTCCTGTCTTTAGTTGGTTAGC
ACTAAGAGGAAAATGTCACCATTGCCAGACGAAAATCAGTGCTCGCTATCCTTTTGTTGAAGCACTGAGCGCCTTTTTGT
GCGGCCTAGTCGCTTGGAAGTTCGGTTATGCACCGATTACCGTAGCACTGATTGGTTTTACTTTGGTGTTGATCGCCGCC
ACCTTCATCGACTTAGATACCATGCTACTGCCTGATCAGCTGACACTGCCGCTGACGTGGGCAGGCATCGCGCTAGCGTT
ACTAGAGATAAGCCCAGTATCTCTGCAAGATTCAGTGATCGGTGCGATGGCAGGCTATCTCTGCCTTTGGAGCGTTTATC
ACCTTTTCCGATTGCTGACAGGGAAAGAAGGCATGGGTTACGGAGACTTTAAATTGCTTGCGGCACTTGGAGCTTGGCTC
GGCTGGCAATATCTACCGATGATCATCTTACTTTCTTCGGTTGTCGGGCTGATCTTTGGTCTCATTCAACTCCGATTGCA
AAAGCAAGGCATTGAGATGGCTTTTCCATTTGGGCCTTATCTGGCCATTGCTGGTTGGGTCGCCTTAATGTGGGGAGATA
GCTTGATGTCTTGGTATCTCAACTATCTTATAGGGGCATAA

Upstream 100 bases:

>100_bases
CGGATTGGTCACCGCAATGTACTTGCCGATCTTTAATTTAATGAGTGTTCTGGGATAAGATAACCCTCGCAGTTTACCTT
TTGTAATATCAAGCAAGCTA

Downstream 100 bases:

>100_bases
TATGGCTTTAGTGATTGGATTGACTGGTGGTATCGCCAGCGGAAAAACGACGGTGGCCAATCTTTTTCAACAACACTTTG
CCATCGATATCGTCGACGCA

Product: type IV prepilin-like proteins leader peptide processing enzyme

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MACLSYFCPHHKENDDYMDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQECAESFPEYNITPPTETLTL
STPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKISARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAA
TFIDLDTMLLPDQLTLPLTWAGIALALLEISPVSLQDSVIGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWL
GWQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYLNYLIGA

Sequences:

>Translated_306_residues
MACLSYFCPHHKENDDYMDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQECAESFPEYNITPPTETLTL
STPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKISARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAA
TFIDLDTMLLPDQLTLPLTWAGIALALLEISPVSLQDSVIGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWL
GWQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYLNYLIGA
>Mature_305_residues
ACLSYFCPHHKENDDYMDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQECAESFPEYNITPPTETLTLS
TPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKISARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAAT
FIDLDTMLLPDQLTLPLTWAGIALALLEISPVSLQDSVIGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWLG
WQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYLNYLIGA

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=267, Percent_Identity=41.1985018726592, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789732, Length=144, Percent_Identity=45.1388888888889, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 34287; Mature: 34156

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACLSYFCPHHKENDDYMDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQ
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ECAESFPEYNITPPTETLTLSTPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKIS
HHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHH
ARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAATFIDLDTMLLPDQLTLPLTW
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AGIALALLEISPVSLQDSVIGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GWQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
NYLIGA
HHHHCC
>Mature Secondary Structure 
ACLSYFCPHHKENDDYMDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQ
CCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ECAESFPEYNITPPTETLTLSTPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKIS
HHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHH
ARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAATFIDLDTMLLPDQLTLPLTW
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AGIALALLEISPVSLQDSVIGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GWQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
NYLIGA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9826339 [H]