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The map label for this gene is bioC [H]

Identifier: 37679513

GI number: 37679513

Start: 1358083

End: 1358892

Strand: Direct

Name: bioC [H]

Synonym: VV1329

Alternate gene names: 37679513

Gene position: 1358083-1358892 (Clockwise)

Preceding gene: 37679512

Following gene: 37679514

Centisome position: 40.49

GC content: 46.3

Gene sequence:

>810_bases
ATGGAAATGGCTAAGGTATCCTTTACTGCGGAGGAAGCGTATGTGGATAAGCTGGCTATTGCTCAAGCATTCGGTAAGGC
GGCTAAAAGCTATGACCAGCATGCGGCATTTCAACGAGAAGTTGGACATAAGTTATTAGATAAACTGCCCCAAGATTTAT
CGGGCTTGCGTGTTTTGGATCTTGGTTGTGGCACGGGGTATTTCTCGTGGCAACTTTTGCAACGAGGCGCTGAAGTCGTA
TGTGCCGACTTATCGCATGAGATGCTTGAGCAGGCAAAGGCCCGTTGTGGGCTAGAGTCGGTGTCGTATCGCGTTGCCGA
TGCGGAGTCTTTGCCATTCGAACGTGATGAGTTTGACATTGTCTTCAGTAGCTTAGCCTTGCAATGGTGCGAGGATTTAT
CGCGGCCTTTACGTGAAATGAACCGTGTTGTAAAACCGCATGGCCAAGTGTTGTTTTCCACATTACTGGATGGCTCACTC
AATGAGCTAAAGCAAGCCTGGGCAAAAATTGACTCATATCAACACGTCAACCGTTTTATCTCTGCCAATCAGGTAAAAAT
TGCGTTAGCGCAATCTCATAGTCATAACCATCATCTAGACTTGACCGATATCACAGTCTGGTACGAGTCTGCGTTTGCTG
TTATGCGTGATCTTAAGGGTATTGGTGCGAACCATGTAAGCGGGCGCTCACATGGTTTAACGACAAGACAAGCGTTAAAA
CGAGTGGAAAGAGAGTACCAGACATTTCAGAACCATCTAGGTCATGTACCGGCAAGTTATAAGGTTTGTTTAGGGGTTAT
ACAGTTATGA

Upstream 100 bases:

>100_bases
AAAACACGGCGCGCCTAAGAATCACGTTGTCTGCTAATCACACAAAAGAACAGATGCACACACTGGCACAAGTACTGCTG
ACAGTTACAGGAGAGCACTA

Downstream 100 bases:

>100_bases
TGAAAGCATTTTTCATTGCAGGTACGGATACCGATGTGGGCAAAACCGTGGCATCTAAAGCGATTCTTCACGCATTAGCG
GCCAAAGATCTACGTACTAT

Product: biotin synthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MEMAKVSFTAEEAYVDKLAIAQAFGKAAKSYDQHAAFQREVGHKLLDKLPQDLSGLRVLDLGCGTGYFSWQLLQRGAEVV
CADLSHEMLEQAKARCGLESVSYRVADAESLPFERDEFDIVFSSLALQWCEDLSRPLREMNRVVKPHGQVLFSTLLDGSL
NELKQAWAKIDSYQHVNRFISANQVKIALAQSHSHNHHLDLTDITVWYESAFAVMRDLKGIGANHVSGRSHGLTTRQALK
RVEREYQTFQNHLGHVPASYKVCLGVIQL

Sequences:

>Translated_269_residues
MEMAKVSFTAEEAYVDKLAIAQAFGKAAKSYDQHAAFQREVGHKLLDKLPQDLSGLRVLDLGCGTGYFSWQLLQRGAEVV
CADLSHEMLEQAKARCGLESVSYRVADAESLPFERDEFDIVFSSLALQWCEDLSRPLREMNRVVKPHGQVLFSTLLDGSL
NELKQAWAKIDSYQHVNRFISANQVKIALAQSHSHNHHLDLTDITVWYESAFAVMRDLKGIGANHVSGRSHGLTTRQALK
RVEREYQTFQNHLGHVPASYKVCLGVIQL
>Mature_269_residues
MEMAKVSFTAEEAYVDKLAIAQAFGKAAKSYDQHAAFQREVGHKLLDKLPQDLSGLRVLDLGCGTGYFSWQLLQRGAEVV
CADLSHEMLEQAKARCGLESVSYRVADAESLPFERDEFDIVFSSLALQWCEDLSRPLREMNRVVKPHGQVLFSTLLDGSL
NELKQAWAKIDSYQHVNRFISANQVKIALAQSHSHNHHLDLTDITVWYESAFAVMRDLKGIGANHVSGRSHGLTTRQALK
RVEREYQTFQNHLGHVPASYKVCLGVIQL

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=237, Percent_Identity=27.8481012658228, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786994, Length=256, Percent_Identity=43.359375, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI48994983, Length=159, Percent_Identity=30.8176100628931, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17535003, Length=250, Percent_Identity=28, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922210, Length=238, Percent_Identity=27.3109243697479, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 30241; Mature: 30241

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMAKVSFTAEEAYVDKLAIAQAFGKAAKSYDQHAAFQREVGHKLLDKLPQDLSGLRVLD
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEE
LGCGTGYFSWQLLQRGAEVVCADLSHEMLEQAKARCGLESVSYRVADAESLPFERDEFDI
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHH
VFSSLALQWCEDLSRPLREMNRVVKPHGQVLFSTLLDGSLNELKQAWAKIDSYQHVNRFI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SANQVKIALAQSHSHNHHLDLTDITVWYESAFAVMRDLKGIGANHVSGRSHGLTTRQALK
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RVEREYQTFQNHLGHVPASYKVCLGVIQL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEMAKVSFTAEEAYVDKLAIAQAFGKAAKSYDQHAAFQREVGHKLLDKLPQDLSGLRVLD
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEE
LGCGTGYFSWQLLQRGAEVVCADLSHEMLEQAKARCGLESVSYRVADAESLPFERDEFDI
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHH
VFSSLALQWCEDLSRPLREMNRVVKPHGQVLFSTLLDGSLNELKQAWAKIDSYQHVNRFI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SANQVKIALAQSHSHNHHLDLTDITVWYESAFAVMRDLKGIGANHVSGRSHGLTTRQALK
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RVEREYQTFQNHLGHVPASYKVCLGVIQL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]