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The map label for this gene is bioF [H]

Identifier: 37679512

GI number: 37679512

Start: 1356926

End: 1358083

Strand: Direct

Name: bioF [H]

Synonym: VV1328

Alternate gene names: 37679512

Gene position: 1356926-1358083 (Clockwise)

Preceding gene: 161486630

Following gene: 37679513

Centisome position: 40.45

GC content: 49.74

Gene sequence:

>1158_bases
ATGACGCAAGCCTTTAACGAAAGAATCGTGCAAGCCCTGAAGCAGAGACGCGAACAGGGCTTGAATCGCCAAAGTGAAGT
GATTTTCTCGGGAAATCAAACGGTTTTAGAACATCAAGGGAAGCGCTATCTCAATTTTTCTGCCAACGACTATTTGGGGT
TGGCAAACGACCAATCTTTAGTTCGAGCTTGGCAGCAGGGTTTGAGTTTATATGGTTGTGGCAGCGGGGCATCTCCATTG
GTGACGGGCTACACGCCTGCGCACAGTAATCTCGCGGCTTCCTTATGTGATTGGCTAGGGTATGAAAGTGCCACTTTGTT
TGGATCGGGATTTTCGGCCAATCAAGCGTTGTTGTTTGCACTGCTTGAAAAAGGCGATCTCCTAGTGCAAGACAAATTAA
ATCACGCTTCTTTAATCGAGGCGGGGCTTTTGTCTCCTGCTAGCATGAAGCGATTTAAGCATAATGATCTTCAAGCACTA
GATGCGATTTTAAACCGATCTGATTGCCCAAGTTTGGTGGTGACGGAAGGCGTATTTAGCATGGATGGTGATTGTTCACC
ATTGGCTGAAATGCACGCACTCACCCAACGCTATTCGGCGAGCTTAATGGTGGACGATGCGCATGGTGTTGGCGTGCTCG
GTGAAGAAGGTCGCGGAAGCTGCGCGCTCGCTAGTGTGAAGCCAGATTTTTTGGTGGTCACCTTTGGTAAAGCATTCGGC
TTATCGGGGGCAGCACTTCTAACGGATAAATCCAGCGGTGATTTCCTTGCTCAATTTGCTCGTCACCACGTTTACTCTAC
CGCGCTTCCGCCTGCACAAGCTTTCGCGTTGACGCATGCCGTGGAGATGATTCGAACGCAGCAGTGGCGACGAGACAAGC
TTAATGAGCTACAAACCCTTTTTGCGGAATATTTGGGGGAGCACGATAGTTTTGTGGCCACTCAAACGCCGATCAAACCG
TGGCTTATTGGAGAGACACAACAAGCCGTGATGGTTGCACAGCGTTGCCGAGAGCAAGGCATTTGGTTGACAGCGATTCG
TCCGCCGACGGTACCCCAAAACACGGCGCGCCTAAGAATCACGTTGTCTGCTAATCACACAAAAGAACAGATGCACACAC
TGGCACAAGTACTGCTGACAGTTACAGGAGAGCACTAA

Upstream 100 bases:

>100_bases
CAGCAAGTCTCACAAAAACCTGATGAAATTACAGAAAACGAATTGTTAGATCGCGTAGTCGAAAGCGTGGCTGCTCGCCC
AACAAAAGACGATCTGTTTT

Downstream 100 bases:

>100_bases
TGGAAATGGCTAAGGTATCCTTTACTGCGGAGGAAGCGTATGTGGATAAGCTGGCTATTGCTCAAGCATTCGGTAAGGCG
GCTAAAAGCTATGACCAGCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTQAFNERIVQALKQRREQGLNRQSEVIFSGNQTVLEHQGKRYLNFSANDYLGLANDQSLVRAWQQGLSLYGCGSGASPL
VTGYTPAHSNLAASLCDWLGYESATLFGSGFSANQALLFALLEKGDLLVQDKLNHASLIEAGLLSPASMKRFKHNDLQAL
DAILNRSDCPSLVVTEGVFSMDGDCSPLAEMHALTQRYSASLMVDDAHGVGVLGEEGRGSCALASVKPDFLVVTFGKAFG
LSGAALLTDKSSGDFLAQFARHHVYSTALPPAQAFALTHAVEMIRTQQWRRDKLNELQTLFAEYLGEHDSFVATQTPIKP
WLIGETQQAVMVAQRCREQGIWLTAIRPPTVPQNTARLRITLSANHTKEQMHTLAQVLLTVTGEH

Sequences:

>Translated_385_residues
MTQAFNERIVQALKQRREQGLNRQSEVIFSGNQTVLEHQGKRYLNFSANDYLGLANDQSLVRAWQQGLSLYGCGSGASPL
VTGYTPAHSNLAASLCDWLGYESATLFGSGFSANQALLFALLEKGDLLVQDKLNHASLIEAGLLSPASMKRFKHNDLQAL
DAILNRSDCPSLVVTEGVFSMDGDCSPLAEMHALTQRYSASLMVDDAHGVGVLGEEGRGSCALASVKPDFLVVTFGKAFG
LSGAALLTDKSSGDFLAQFARHHVYSTALPPAQAFALTHAVEMIRTQQWRRDKLNELQTLFAEYLGEHDSFVATQTPIKP
WLIGETQQAVMVAQRCREQGIWLTAIRPPTVPQNTARLRITLSANHTKEQMHTLAQVLLTVTGEH
>Mature_384_residues
TQAFNERIVQALKQRREQGLNRQSEVIFSGNQTVLEHQGKRYLNFSANDYLGLANDQSLVRAWQQGLSLYGCGSGASPLV
TGYTPAHSNLAASLCDWLGYESATLFGSGFSANQALLFALLEKGDLLVQDKLNHASLIEAGLLSPASMKRFKHNDLQALD
AILNRSDCPSLVVTEGVFSMDGDCSPLAEMHALTQRYSASLMVDDAHGVGVLGEEGRGSCALASVKPDFLVVTFGKAFGL
SGAALLTDKSSGDFLAQFARHHVYSTALPPAQAFALTHAVEMIRTQQWRRDKLNELQTLFAEYLGEHDSFVATQTPIKPW
LIGETQQAVMVAQRCREQGIWLTAIRPPTVPQNTARLRITLSANHTKEQMHTLAQVLLTVTGEH

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=31.3218390804598, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=31.3218390804598, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI119220554, Length=371, Percent_Identity=30.4582210242588, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=30.1369863013699, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI83977442, Length=350, Percent_Identity=30, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=30, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=30, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=30.0578034682081, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=30.0578034682081, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5454084, Length=192, Percent_Identity=26.5625, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=51.304347826087, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1790046, Length=380, Percent_Identity=33.9473684210526, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=367, Percent_Identity=30.2452316076294, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=381, Percent_Identity=29.3963254593176, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=381, Percent_Identity=29.3963254593176, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=25.7372654155496, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=275, Percent_Identity=24.7272727272727, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=275, Percent_Identity=24.7272727272727, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=29.4906166219839, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=360, Percent_Identity=27.5, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=303, Percent_Identity=25.7425742574257, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24662918, Length=372, Percent_Identity=31.4516129032258, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137420, Length=394, Percent_Identity=29.6954314720812, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17136286, Length=381, Percent_Identity=30.1837270341207, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653280, Length=252, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653276, Length=252, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24653278, Length=252, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42070; Mature: 41939

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAFNERIVQALKQRREQGLNRQSEVIFSGNQTVLEHQGKRYLNFSANDYLGLANDQSL
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCCEEEECCCCCCEECCCCHHH
VRAWQQGLSLYGCGSGASPLVTGYTPAHSNLAASLCDWLGYESATLFGSGFSANQALLFA
HHHHHHCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHH
LLEKGDLLVQDKLNHASLIEAGLLSPASMKRFKHNDLQALDAILNRSDCPSLVVTEGVFS
HHHCCCEEEECCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCC
MDGDCSPLAEMHALTQRYSASLMVDDAHGVGVLGEEGRGSCALASVKPDFLVVTFGKAFG
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEECCCCCCCEEEEECCCCEEEEEECHHHC
LSGAALLTDKSSGDFLAQFARHHVYSTALPPAQAFALTHAVEMIRTQQWRRDKLNELQTL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAEYLGEHDSFVATQTPIKPWLIGETQQAVMVAQRCREQGIWLTAIRPPTVPQNTARLRI
HHHHHCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEE
TLSANHTKEQMHTLAQVLLTVTGEH
EEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQAFNERIVQALKQRREQGLNRQSEVIFSGNQTVLEHQGKRYLNFSANDYLGLANDQSL
CCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCCEEEECCCCCCEECCCCHHH
VRAWQQGLSLYGCGSGASPLVTGYTPAHSNLAASLCDWLGYESATLFGSGFSANQALLFA
HHHHHHCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHH
LLEKGDLLVQDKLNHASLIEAGLLSPASMKRFKHNDLQALDAILNRSDCPSLVVTEGVFS
HHHCCCEEEECCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCC
MDGDCSPLAEMHALTQRYSASLMVDDAHGVGVLGEEGRGSCALASVKPDFLVVTFGKAFG
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEECCCCCCCEEEEECCCCEEEEEECHHHC
LSGAALLTDKSSGDFLAQFARHHVYSTALPPAQAFALTHAVEMIRTQQWRRDKLNELQTL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAEYLGEHDSFVATQTPIKPWLIGETQQAVMVAQRCREQGIWLTAIRPPTVPQNTARLRI
HHHHHCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEE
TLSANHTKEQMHTLAQVLLTVTGEH
EEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA