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The map label for this gene is moaB [H]

Identifier: 37679383

GI number: 37679383

Start: 1215827

End: 1216339

Strand: Direct

Name: moaB [H]

Synonym: VV1199

Alternate gene names: 37679383

Gene position: 1215827-1216339 (Clockwise)

Preceding gene: 37679382

Following gene: 37679384

Centisome position: 36.24

GC content: 45.81

Gene sequence:

>513_bases
ATGGGTCACGCTGAAAGTAAATTCCAACCAGCGAATATCGCTGTTCTAACTGTTTCTGATACACGCACGGAAGAAAATGA
TACTTCTGGTGCGTACCTCGTCGAAAATGCAAAAGAAGCAGGCCACAACGTGGTCGACAAACAAATTGTCATCGATGACA
TGTACAAGATTCGTGCGATCGTCTCTCAATGGATCGCAGATGAAAACGTGCAAGCGATCATGATCACTGGTGGTACCGGA
TTCACTTCTCGCGACAGTACTCCTGAAGCTCTAAAACCGCTTTTCGACAAAGAGGTTGAAGGTTTTGGTGAGTTGTTCCG
TTTGGTTTCTTATGAAGAAATTGGCACTTCGACGATTCAATCTCGCGCGATTGCCGGTTTTGCAAATCATACAGTGATTT
TTGCTATGCCTGGCTCAACGGGGGCTTGTCGTACGGGTTGGACTAAAATCATCAAGCAACAATTGGATGCGAGCCATCGT
CCTTGCAACTTTATGCCTCACCTGAGCGTATAA

Upstream 100 bases:

>100_bases
TAGCATCTATTGGCGGCTAATACAGAACAAAGAATACCTCTAAGGCGGTCACGATGATGACCACCGATAACGCTATTAAC
TCAAGAAAAAAGGTGAACAC

Downstream 100 bases:

>100_bases
AGGAGAGCCCATGAGCCAGTTTACTCACATCAACGCCTCTGGCGAAGCAAACATGGTGGATGTATCTGCCAAAGCTGAAA
CGGTACGCGAAGCACGTGCG

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MGHAESKFQPANIAVLTVSDTRTEENDTSGAYLVENAKEAGHNVVDKQIVIDDMYKIRAIVSQWIADENVQAIMITGGTG
FTSRDSTPEALKPLFDKEVEGFGELFRLVSYEEIGTSTIQSRAIAGFANHTVIFAMPGSTGACRTGWTKIIKQQLDASHR
PCNFMPHLSV

Sequences:

>Translated_170_residues
MGHAESKFQPANIAVLTVSDTRTEENDTSGAYLVENAKEAGHNVVDKQIVIDDMYKIRAIVSQWIADENVQAIMITGGTG
FTSRDSTPEALKPLFDKEVEGFGELFRLVSYEEIGTSTIQSRAIAGFANHTVIFAMPGSTGACRTGWTKIIKQQLDASHR
PCNFMPHLSV
>Mature_169_residues
GHAESKFQPANIAVLTVSDTRTEENDTSGAYLVENAKEAGHNVVDKQIVIDDMYKIRAIVSQWIADENVQAIMITGGTGF
TSRDSTPEALKPLFDKEVEGFGELFRLVSYEEIGTSTIQSRAIAGFANHTVIFAMPGSTGACRTGWTKIIKQQLDASHRP
CNFMPHLSV

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI10880983, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787000, Length=168, Percent_Identity=64.8809523809524, Blast_Score=234, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17136978, Length=139, Percent_Identity=36.6906474820144, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24638841, Length=139, Percent_Identity=36.6906474820144, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 18606; Mature: 18475

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHAESKFQPANIAVLTVSDTRTEENDTSGAYLVENAKEAGHNVVDKQIVIDDMYKIRAI
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECHHHCCCCHHHHHHHHHHHHHHHHH
VSQWIADENVQAIMITGGTGFTSRDSTPEALKPLFDKEVEGFGELFRLVSYEEIGTSTIQ
HHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
SRAIAGFANHTVIFAMPGSTGACRTGWTKIIKQQLDASHRPCNFMPHLSV
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GHAESKFQPANIAVLTVSDTRTEENDTSGAYLVENAKEAGHNVVDKQIVIDDMYKIRAI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECHHHCCCCHHHHHHHHHHHHHHHHH
VSQWIADENVQAIMITGGTGFTSRDSTPEALKPLFDKEVEGFGELFRLVSYEEIGTSTIQ
HHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
SRAIAGFANHTVIFAMPGSTGACRTGWTKIIKQQLDASHRPCNFMPHLSV
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]