Click here to switch to the map view.

The map label for this gene is moaA

Identifier: 37679382

GI number: 37679382

Start: 1214757

End: 1215746

Strand: Direct

Name: moaA

Synonym: VV1198

Alternate gene names: 37679382

Gene position: 1214757-1215746 (Clockwise)

Preceding gene: 37679380

Following gene: 37679383

Centisome position: 36.21

GC content: 45.25

Gene sequence:

>990_bases
GTGGCGCAACAATTCGAAGATAGATTCCACCGCAAATTCTATTACTTGCGTTTGTCTGTGACGGACGTGTGTAATTTCAA
ATGTACCTATTGTCTGCCTGATGGTTACCAACCTTCGGGGCAGAAAAACTCGTCTTTTTTAAACCTCTCTGAAATCCGTC
GAGTCGTTAAGGCTTTTGCTGACTGTGGCACAAGTAAAGTGCGTATTACTGGCGGAGAGCCAAGTCTGCGTAAAGATTTT
ACTGACATTATCCACACGGTCGCGTCAACTCAAGGCATTAAACGAGTTGCCACTACCACCAATGGCTATCGAATGGAAAA
GCATATTGGAGAATGGAAAGAAGCAGGTTTAAACCAAATTAATGTCAGCGTGGATAGCCTTGACCCACGTATGTTCCATC
AAATCACTGGCGAGAATAAATTTCACCAAGTGATGTCGGGGATTGATCGCGCGTTTGAAGTGGGGTTTGAACAAGTGAAA
GTCAACGTTGTGTTGATGAAAGATCTCAACCACAACGAGTTACCTGCTTTTTTGCACTGGATTAAGCATCGTCCCATCCA
ATTGCGTTTTATCGAACTGATGCAAACGGGTGAGATGGATACTTTATTCCAACAACATCATGTCTCTGGTGTGGCGATTC
GCAATCATCTGATCGCAAATGGCTGGTTACTGAAAGTGAAGGCGGCTAATGATGGCCCTGCGCAAGTGTTCGTTCACCCT
GATTATCAAGGTGAGATTGGTTTGATCATGCCTTACGAAAAAGACTTTTGTGCGAGCTGTAACCGCTTACGAGTTTCTGC
AAAAGGCAAACTGCATTTGTGTCTATTTGGTGATCGAGGCGTCGAGCTTCGCGACCTGATGCAACAAGACGATCAAGAGC
CTGATCTCATTGCCCGAATTCAGTCGGAGTTACAGACTAAATCTGTCAGCCATTTCTTAAACGAAGGTCAGACGGGCATG
ACGCCGCACTTAGCATCTATTGGCGGCTAA

Upstream 100 bases:

>100_bases
TATTTCAATGATGGAATGATAAGCAGCTTAAGCCAGTGACATGATGTCACAAGGGCGTAATTGGAAATGACTACGCCTCC
CGTGTTTGGAAAGGTGTTCC

Downstream 100 bases:

>100_bases
TACAGAACAAAGAATACCTCTAAGGCGGTCACGATGATGACCACCGATAACGCTATTAACTCAAGAAAAAAGGTGAACAC
ATGGGTCACGCTGAAAGTAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFADCGTSKVRITGGEPSLRKDF
TDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVK
VNVVLMKDLNHNELPAFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQVFVHP
DYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLMQQDDQEPDLIARIQSELQTKSVSHFLNEGQTGM
TPHLASIGG

Sequences:

>Translated_329_residues
MAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFADCGTSKVRITGGEPSLRKDF
TDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVK
VNVVLMKDLNHNELPAFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQVFVHP
DYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLMQQDDQEPDLIARIQSELQTKSVSHFLNEGQTGM
TPHLASIGG
>Mature_328_residues
AQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFADCGTSKVRITGGEPSLRKDFT
DIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQINVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVKV
NVVLMKDLNHNELPAFLHWIKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQVFVHPD
YQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLMQQDDQEPDLIARIQSELQTKSVSHFLNEGQTGMT
PHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=309, Percent_Identity=35.9223300970874, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI22027536, Length=309, Percent_Identity=35.9223300970874, Blast_Score=204, Evalue=8e-53,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=64.1337386018237, Blast_Score=467, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=36.2275449101796, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=310, Percent_Identity=37.741935483871, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=310, Percent_Identity=37.741935483871, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI28574488, Length=332, Percent_Identity=34.0361445783133, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=33.7579617834395, Blast_Score=194, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37375; Mature: 37244

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFA
CCCHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHH
DCGTSKVRITGGEPSLRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQI
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHCCCCEE
NVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVKVNVVLMKDLNHNELPAFLHW
EEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHHHHHHH
IKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQVFVHP
HHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHEEEECCEEEEEEECCCCCEEEEECC
DYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLMQQDDQEPDLIARI
CCCCCEEEEECCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHH
QSELQTKSVSHFLNEGQTGMTPHLASIGG
HHHHHHHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure 
AQQFEDRFHRKFYYLRLSVTDVCNFKCTYCLPDGYQPSGQKNSSFLNLSEIRRVVKAFA
CCHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHH
DCGTSKVRITGGEPSLRKDFTDIIHTVASTQGIKRVATTTNGYRMEKHIGEWKEAGLNQI
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHCCCCEE
NVSVDSLDPRMFHQITGENKFHQVMSGIDRAFEVGFEQVKVNVVLMKDLNHNELPAFLHW
EEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHHHHHHH
IKHRPIQLRFIELMQTGEMDTLFQQHHVSGVAIRNHLIANGWLLKVKAANDGPAQVFVHP
HHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHEEEECCEEEEEEECCCCCEEEEECC
DYQGEIGLIMPYEKDFCASCNRLRVSAKGKLHLCLFGDRGVELRDLMQQDDQEPDLIARI
CCCCCEEEEECCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHH
QSELQTKSVSHFLNEGQTGMTPHLASIGG
HHHHHHHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA