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The map label for this gene is murA [H]

Identifier: 37678645

GI number: 37678645

Start: 446445

End: 447710

Strand: Direct

Name: murA [H]

Synonym: VV0461

Alternate gene names: 37678645

Gene position: 446445-447710 (Clockwise)

Preceding gene: 37678644

Following gene: 37678646

Centisome position: 13.31

GC content: 50.87

Gene sequence:

>1266_bases
ATGGAAAAGTTCCGTGTAATTGGGTCGACTCAGCCATTGATGGGTGAGGTGACTATTTCAGGTGCCAAAAACGCTGCACT
GCCGATTTTATTTGCGTCGATTCTGGCTGAAGAGCCAGTTGAAGTGGCCAATGTGCCGCATCTTCGAGATATTGATACCA
CCATGGAGCTGCTAAAGCGCCTTGGTGCCAAAGTGGAACGAAATGGTTCCGTTCATGTTGACCCTAGCTCTATCGATGAA
TATTGCGCGCCTTATGATTTGGTGAAAACCATGCGTGCATCGATCTGGGCATTAGGGCCGCTTGTTGCTCGTTTCGGTCA
AGGACAAGTGTCTCTGCCGGGTGGTTGTGCGATCGGTGCTCGTCCCGTGGATTTACACATCACTGGTCTTGAGCAACTAG
GTGCCACCATCACATTAGAAGATGGTTACGTTAAAGCGCATGTCGACGGCCGTTTACAAGGCGCACACATTGTCATGGAC
AAAGTGAGCGTAGGTGCCACGATCACCATCATGTGTGCAGCCACACTTGCCGAAGGCACGACGGTTTTAGATAACGCAGC
GCGTGAGCCAGAAATTGTCGATACCGCGAAATTCCTCAACACGCTTGGGGCTAAAATCAGCGGTGCAGGCACTGACACCA
TCACCATTGAGGGCGTTGAACGTCTGGGTGGTGGTAAGCATGCCGTGGTGGCAGACCGCATCGAAACGGGGACTTTCCTT
GTTGCTGCAGCGGTGTCTGGCGGTAAAGTCGTTTGCCACAATACGCAAGCGCATTTACTTGAAGCCGTGTTGGCGAAGTT
GGAAGAAGCGGGCGCCTTGGTTGAAACTGGTGAAGATTGGATTTCTGTCGATATGACAGGTCGAGAGCTCAAAGCGGTCA
ATATCCGCACGGCGCCTCACCCGGGTTTCCCGACCGATATGCAAGCACAGTTTACCTTGCTGAATATGATGGCGAAAGGC
GGTGGTGTGATCACTGAAACCATCTTTGAAAACCGTTTCATGCATGTTCCAGAGCTAAAACGTATGGGTGCAAAAGCGGA
GATTGAAGGTAACACTGTCATCTGTGGTGACGTGGAGCGTTTGAGCGCAGCACAAGTTATGGCGACCGATCTACGAGCGT
CAGCCAGCTTAGTGATTGCAGGTTGTATCGCTAAGGGTGAAACCATCGTTGATCGCATTTACCACATTGACCGTGGCTAC
GACAAAATCGAGAACAAGCTTAATGCACTGGGTGCAAAGATTGAGCGTTTTCGTGAGTCAAACTAA

Upstream 100 bases:

>100_bases
CTACATCCAACGCAATGATATTCATGCCTTGTCGATCAAAGCATACACGCCCGCCGAATGGGCACGTGACAAGAAACTGA
TGTCTCTTTAAGGTTTTATA

Downstream 100 bases:

>100_bases
ACTACGTTGATACCAATATAGCCGAAACACAGGTTTCGGCTTTTTTACATTTTAGAAGCTGTTTTTGTCAGAGAAGTAGC
GCGTAACTTTCAATATCTTG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKRLGAKVERNGSVHVDPSSIDE
YCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMD
KVSVGATITIMCAATLAEGTTVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFL
VAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPHPGFPTDMQAQFTLLNMMAKG
GGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVERLSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGY
DKIENKLNALGAKIERFRESN

Sequences:

>Translated_421_residues
MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKRLGAKVERNGSVHVDPSSIDE
YCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMD
KVSVGATITIMCAATLAEGTTVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFL
VAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPHPGFPTDMQAQFTLLNMMAKG
GGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVERLSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGY
DKIENKLNALGAKIERFRESN
>Mature_421_residues
MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKRLGAKVERNGSVHVDPSSIDE
YCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMD
KVSVGATITIMCAATLAEGTTVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFL
VAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPHPGFPTDMQAQFTLLNMMAKG
GGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVERLSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGY
DKIENKLNALGAKIERFRESN

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine [H]

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=78.2296650717703, Blast_Score=676, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.7 [H]

Molecular weight: Translated: 44740; Mature: 44740

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKR
CCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
LGAKVERNGSVHVDPSSIDEYCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGA
HCCCEECCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
RPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMDKVSVGATITIMCAATLAEGT
EEEEEEEECHHHHCCEEEEECCEEEEEECCCCCCCEEEEEECCCCCEEEEEEEHHHHCCC
TVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFL
HHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEEHHHCCCCCEEEEEECCCCCEEE
VAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPH
EEEECCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCEEEEEEEEECCC
PGFPTDMQAQFTLLNMMAKGGGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVER
CCCCCCCHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCHHHHCCCCEEECCCEEEECCHHH
LSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGYDKIENKLNALGAKIERFRES
HHHHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
N
C
>Mature Secondary Structure
MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKR
CCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
LGAKVERNGSVHVDPSSIDEYCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGA
HCCCEECCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
RPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMDKVSVGATITIMCAATLAEGT
EEEEEEEECHHHHCCEEEEECCEEEEEECCCCCCCEEEEEECCCCCEEEEEEEHHHHCCC
TVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFL
HHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEEHHHCCCCCEEEEEECCCCCEEE
VAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPH
EEEECCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCEEEEEEEEECCC
PGFPTDMQAQFTLLNMMAKGGGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVER
CCCCCCCHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCHHHHCCCCEEECCCEEEECCHHH
LSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGYDKIENKLNALGAKIERFRES
HHHHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA