Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 161486631

GI number: 161486631

Start: 1353103

End: 1354410

Strand: Direct

Name: serS [H]

Synonym: VV1325

Alternate gene names: 161486631

Gene position: 1353103-1354410 (Clockwise)

Preceding gene: 37679508

Following gene: 161486630

Centisome position: 40.34

GC content: 46.79

Gene sequence:

>1308_bases
ATGCTGGATTCTAAATTACTTCGTACAGAGCTGGATGAAACAGCTGCTAAACTGGCACGTCGTGGCTTTAAGCTAGACGT
AGAGACAATCGGTAAACTTGAAGAACAACGTAAGTCCATTCAAGTAGAAGTTGAAAATTTACAATCCACGCGTAACTCCA
TCTCCAAGCAAATCGGTCAACTGATGTCGGCTGGCGACAAAGAAGGCGCAGAAAAGATCAAGCAACAAATCGGGTCATTA
GGCTCTGATTTAGATGTGAAAAAAATTGAACTTGACGCGGTGATGGCGCAGTTAGATGACATCATCCTTTCTGTTCCAAA
CATTCCTGCGGATGAAGTGCCAAATGGCAAAGACGAGAACGATAATCTTGAGATTTCGCGTTGGGGTGAGCCAAAGTCTT
ACGACTTCGAATTAAAAGATCACGTTGACCTAGGTGAAATGGGTGACGGTCTAGATTTCGCAAGCGCAGTTAAGATCACT
GGTGCGCGTTTCATCGTGATGAAGGGTCAATTTGCTCGCCTACACCGTGCAATCGCTCAGTTTATGCTTGATCTTCACAC
TGAAGAGCATGGCTATACGGAAATGTATGTGCCTTACCTAGTGAACGCAGACAGCTTGTTTGGTACGGGCCAACTACCAA
AGTTTGGTAAAGATCTTTTCCACACAGAGCCTCTGACAGAAAAGGCAAGTGATGAAGAGCCACGTAAACTGTCTCTTATC
CCTACAGCAGAAGTACCAGTAACGAACCTTGTTCGCGACACGATTTCTGATGAAGCTGATCTGCCGCTTAAGATGACCGC
TCACACGCCGTGTTTCCGTTCAGAAGCAGGGTCGTACGGTCGTGACACTCGTGGTCTGATTCGTATGCACCAGTTTGACA
AAGTAGAACTGGTACAAATCACCAAACCAGAAGATTCGATGAATGCACTAGAAGAGCTAACTGGCCATGCTGAGAAAGTG
CTTCAGCTTCTAGAGTTGCCTTACCGTAAGGTGCTATTGTGTACCGGTGACATGGGCTTTGGCTCGCACAAAACTTACGA
TTTGGAAGTATGGGTTCCGGCTCAGAACACTTACCGCGAAATCTCATCTTGTTCAAACATGTGGGATTTCCAAGCGCGTC
GTATGCAAGCGCGTTTCCGTCGTAAAGGCGAGAAGAAACCTGAACTTGTACACACACTAAACGGTTCTGGTCTGGCGGTA
GGTCGTACCATGGTTGCTATCCTAGAAAACAACCAAGAAGCAGATGGCCGCATTGCCATTCCGACCGTACTTCAGAAGTA
CATGGGCGGCGCAACGCACATCGGTTAA

Upstream 100 bases:

>100_bases
GAAAAGTAGGCATTTTTGGATACATTTGTTCGGTTAATTTTTTCAACGTGCTCGACAGGATTGGGTGCGTACCTTCACAA
CAAAAAGCATAGGATTAACA

Downstream 100 bases:

>100_bases
TTGATTAACCATAAAAAATATTAAAACCCAGCCACTGTGCTGGGTTTTTTATTATCTCGTGCTAAACAAAACACTCGGCA
CGCTGAAGTGCGGTTTCAAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIGKLEEQRKSIQVEVENLQSTRNSISKQIGQLMSAGDKEGAEKIKQQIGSL
GSDLDVKKIELDAVMAQLDDIILSVPNIPADEVPNGKDENDNLEISRWGEPKSYDFELKDHVDLGEMGDGLDFASAVKIT
GARFIVMKGQFARLHRAIAQFMLDLHTEEHGYTEMYVPYLVNADSLFGTGQLPKFGKDLFHTEPLTEKASDEEPRKLSLI
PTAEVPVTNLVRDTISDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMNALEELTGHAEKV
LQLLELPYRKVLLCTGDMGFGSHKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQKYMGGATHIG

Sequences:

>Translated_435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIGKLEEQRKSIQVEVENLQSTRNSISKQIGQLMSAGDKEGAEKIKQQIGSL
GSDLDVKKIELDAVMAQLDDIILSVPNIPADEVPNGKDENDNLEISRWGEPKSYDFELKDHVDLGEMGDGLDFASAVKIT
GARFIVMKGQFARLHRAIAQFMLDLHTEEHGYTEMYVPYLVNADSLFGTGQLPKFGKDLFHTEPLTEKASDEEPRKLSLI
PTAEVPVTNLVRDTISDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMNALEELTGHAEKV
LQLLELPYRKVLLCTGDMGFGSHKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQKYMGGATHIG
>Mature_435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIGKLEEQRKSIQVEVENLQSTRNSISKQIGQLMSAGDKEGAEKIKQQIGSL
GSDLDVKKIELDAVMAQLDDIILSVPNIPADEVPNGKDENDNLEISRWGEPKSYDFELKDHVDLGEMGDGLDFASAVKIT
GARFIVMKGQFARLHRAIAQFMLDLHTEEHGYTEMYVPYLVNADSLFGTGQLPKFGKDLFHTEPLTEKASDEEPRKLSLI
PTAEVPVTNLVRDTISDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMNALEELTGHAEKV
LQLLELPYRKVLLCTGDMGFGSHKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQKYMGGATHIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=435, Percent_Identity=31.7241379310345, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI8923421, Length=413, Percent_Identity=27.1186440677966, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI225579074, Length=416, Percent_Identity=27.1634615384615, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=70.5747126436782, Blast_Score=653, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=31.4942528735632, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=385, Percent_Identity=24.1558441558442, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320226, Length=410, Percent_Identity=30.4878048780488, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321799, Length=413, Percent_Identity=28.5714285714286, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24581334, Length=446, Percent_Identity=31.6143497757848, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737985, Length=269, Percent_Identity=32.3420074349442, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48675; Mature: 48675

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRTELDETAAKLARRGFKLDVETIGKLEEQRKSIQVEVENLQSTRNSISKQIGQ
CCCHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSAGDKEGAEKIKQQIGSLGSDLDVKKIELDAVMAQLDDIILSVPNIPADEVPNGKDEN
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DNLEISRWGEPKSYDFELKDHVDLGEMGDGLDFASAVKITGARFIVMKGQFARLHRAIAQ
CCEEEEECCCCCCCCCCHHCCCCCCCCCCCCCHHHHHEECCEEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYTEMYVPYLVNADSLFGTGQLPKFGKDLFHTEPLTEKASDEEPRKLSLI
HHHHHHCCCCCCEEEEECEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEE
PTAEVPVTNLVRDTISDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
TKPEDSMNALEELTGHAEKVLQLLELPYRKVLLCTGDMGFGSHKTYDLEVWVPAQNTYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENNQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHEEEEEECCCCCCCEEEH
PTVLQKYMGGATHIG
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDSKLLRTELDETAAKLARRGFKLDVETIGKLEEQRKSIQVEVENLQSTRNSISKQIGQ
CCCHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSAGDKEGAEKIKQQIGSLGSDLDVKKIELDAVMAQLDDIILSVPNIPADEVPNGKDEN
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DNLEISRWGEPKSYDFELKDHVDLGEMGDGLDFASAVKITGARFIVMKGQFARLHRAIAQ
CCEEEEECCCCCCCCCCHHCCCCCCCCCCCCCHHHHHEECCEEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYTEMYVPYLVNADSLFGTGQLPKFGKDLFHTEPLTEKASDEEPRKLSLI
HHHHHHCCCCCCEEEEECEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEE
PTAEVPVTNLVRDTISDEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
TKPEDSMNALEELTGHAEKVLQLLELPYRKVLLCTGDMGFGSHKTYDLEVWVPAQNTYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENNQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHEEEEEECCCCCCCEEEH
PTVLQKYMGGATHIG
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA