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The map label for this gene is era [H]

Identifier: 37523991

GI number: 37523991

Start: 4648089

End: 4649003

Strand: Direct

Name: era [H]

Synonym: glr4422

Alternate gene names: 37523991

Gene position: 4648089-4649003 (Clockwise)

Preceding gene: 37523990

Following gene: 37523993

Centisome position: 99.77

GC content: 59.23

Gene sequence:

>915_bases
ATGATTATCCCCGAAGCGCCGCCGGGCTTTCGCTCGGGTTTTGTCGCCATCGTCGGCCGCCCCAACGTCGGCAAATCGAC
GCTGGTCAACCGGCTGGTGGGCGAGAAAGTCGCTATCGTCTCCCCAACTGCCCAGACGACCCGCAACCGCCTGCGGGGCA
TTCTCACATTGCCCACCGCTCAGATCATTCTGGTAGATACACCAGGGATCCATAAGCCTCAGCACCGTCTGGGCGAAGTG
CTGGTTCACAATGCCCGCAGCGCAGCGGGATCCGCTGACGGGATTGTCTTGGTCGTCGATGGCTCGGTGGAAGCCGGGGC
GGGCGACCGGTTCATTGCCGAGAGCCTCAAAGGGAGCAAAGCGCCTGTCTGGCCGGTGCTCAACAAAGTCGATCGCCGCT
CTCGAAATCAGGTGGAACCTATCCGCGAGAGTTACCGCAAGCTGTTCGACCCGGAACTGGTGTTCTACGAAATTTCGGCC
CTCAAAGGTTCCGGGATTGAACCTCTAATGGAGAGCATTATTTCAAGCCTGCCCGAAGGGCCGTACTACTACCCGCCGGA
TCTGTTCACCGATCAACCCGAGCGGTTCATCATGGGCGAACTCGTCCGCGAACAGGTGCTGCTTGCTACCCGCGAGGAAG
TACCCCATTCGGTGGCAGTGGTGATCGACAAAGTCGAAGAAGGCGAAACTCTCACCCGCGTGCTCGCCACGATCATGGTA
GAGCGGGATTCCCAGAAGATTATTTTGATTGGCAAGGGCGGTCAGATGCTCAAGGCAATCGGCACCGGTGCCCGCCACCA
AATGCAGAAACTGGTGGGCCACCAGATTTACTTGCAGCTATTTGTGAAGGTCAAGGAGCGTTGGCGCCAGTCCGACTCGA
CGCTGCGGGATTTGGGGTACCGCCGGGAGCAGTGA

Upstream 100 bases:

>100_bases
CCCTCAACACCGCCATTGAGGGCGAAATCGAAACGCTCATCCAATCGGCCATCGCTGCCGCCCAGCGCGAACAACTCGCG
GAACTGGCCCGCAGCAGCGG

Downstream 100 bases:

>100_bases
GGGCGAAGCGTTTAAAGAAGCTCGCTGCGTTCCACTCGGGACGCTCCGACTGGTTGGCGACTCGCACCAACAGTCCTTCG
ATGATCCGGTTGAATTTGGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIIPEAPPGFRSGFVAIVGRPNVGKSTLVNRLVGEKVAIVSPTAQTTRNRLRGILTLPTAQIILVDTPGIHKPQHRLGEV
LVHNARSAAGSADGIVLVVDGSVEAGAGDRFIAESLKGSKAPVWPVLNKVDRRSRNQVEPIRESYRKLFDPELVFYEISA
LKGSGIEPLMESIISSLPEGPYYYPPDLFTDQPERFIMGELVREQVLLATREEVPHSVAVVIDKVEEGETLTRVLATIMV
ERDSQKIILIGKGGQMLKAIGTGARHQMQKLVGHQIYLQLFVKVKERWRQSDSTLRDLGYRREQ

Sequences:

>Translated_304_residues
MIIPEAPPGFRSGFVAIVGRPNVGKSTLVNRLVGEKVAIVSPTAQTTRNRLRGILTLPTAQIILVDTPGIHKPQHRLGEV
LVHNARSAAGSADGIVLVVDGSVEAGAGDRFIAESLKGSKAPVWPVLNKVDRRSRNQVEPIRESYRKLFDPELVFYEISA
LKGSGIEPLMESIISSLPEGPYYYPPDLFTDQPERFIMGELVREQVLLATREEVPHSVAVVIDKVEEGETLTRVLATIMV
ERDSQKIILIGKGGQMLKAIGTGARHQMQKLVGHQIYLQLFVKVKERWRQSDSTLRDLGYRREQ
>Mature_304_residues
MIIPEAPPGFRSGFVAIVGRPNVGKSTLVNRLVGEKVAIVSPTAQTTRNRLRGILTLPTAQIILVDTPGIHKPQHRLGEV
LVHNARSAAGSADGIVLVVDGSVEAGAGDRFIAESLKGSKAPVWPVLNKVDRRSRNQVEPIRESYRKLFDPELVFYEISA
LKGSGIEPLMESIISSLPEGPYYYPPDLFTDQPERFIMGELVREQVLLATREEVPHSVAVVIDKVEEGETLTRVLATIMV
ERDSQKIILIGKGGQMLKAIGTGARHQMQKLVGHQIYLQLFVKVKERWRQSDSTLRDLGYRREQ

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=331, Percent_Identity=26.8882175226586, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788919, Length=295, Percent_Identity=36.9491525423729, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87082120, Length=160, Percent_Identity=31.875, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33684; Mature: 33684

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPEAPPGFRSGFVAIVGRPNVGKSTLVNRLVGEKVAIVSPTAQTTRNRLRGILTLPTA
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHCEEEEECCE
QIILVDTPGIHKPQHRLGEVLVHNARSAAGSADGIVLVVDGSVEAGAGDRFIAESLKGSK
EEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCC
APVWPVLNKVDRRSRNQVEPIRESYRKLFDPELVFYEISALKGSGIEPLMESIISSLPEG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
PYYYPPDLFTDQPERFIMGELVREQVLLATREEVPHSVAVVIDKVEEGETLTRVLATIMV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHEECCCCCCHHHHHHHHHHHH
ERDSQKIILIGKGGQMLKAIGTGARHQMQKLVGHQIYLQLFVKVKERWRQSDSTLRDLGY
CCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
RREQ
CCCC
>Mature Secondary Structure
MIIPEAPPGFRSGFVAIVGRPNVGKSTLVNRLVGEKVAIVSPTAQTTRNRLRGILTLPTA
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHCEEEEECCE
QIILVDTPGIHKPQHRLGEVLVHNARSAAGSADGIVLVVDGSVEAGAGDRFIAESLKGSK
EEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCC
APVWPVLNKVDRRSRNQVEPIRESYRKLFDPELVFYEISALKGSGIEPLMESIISSLPEG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
PYYYPPDLFTDQPERFIMGELVREQVLLATREEVPHSVAVVIDKVEEGETLTRVLATIMV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHEECCCCCCHHHHHHHHHHHH
ERDSQKIILIGKGGQMLKAIGTGARHQMQKLVGHQIYLQLFVKVKERWRQSDSTLRDLGY
CCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
RREQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]