Click here to switch to the map view.

The map label for this gene is prk [H]

Identifier: 37523993

GI number: 37523993

Start: 4650743

End: 4651672

Strand: Direct

Name: prk [H]

Synonym: gvip575

Alternate gene names: 37523993

Gene position: 4650743-4651672 (Clockwise)

Preceding gene: 37523991

Following gene: 37523994

Centisome position: 99.82

GC content: 63.12

Gene sequence:

>930_bases
ATGGCACAACGTCCGATCATTCTCGGCATCGTCGGCGACAGCGCGGCGGGCAAGACCACCCTGACGCGAGGCCTCGCCCA
GATCCTCGGCCCCGACAATGTCACGATCATCTGCACCGACGATTACCATCGCTACGACCGCAAGCAGCGCGCCGAACTGG
GGATCACTGCCCTGCACCCCGATTGCAACTACCTCGACATCATCCAGCAGCACCTCGCTTTGCTGCGCACCGGCCAGCCG
ATCTTAAAGCCCATCTACAACCACAAAACCGGTACCTTCGATCCGCCCGAGTACATCAAACCGCGCAATTTTGTGGTGGT
CGAGGGGCTATTGGGTTTCTCGACGCGGGGGATGCGCGATTGCTACGACGTCAAAGCCTACCTGGCTCCCCCGGAGTCGC
TGCGTACCCGCTGGAAAATCAGGCGTGACACCGCCAAGCGCGGGTACTCCGAGGAGCAGGTGCTGGGCGAAATGGCCAAG
CGCGAACCCGACTCGGAGCAGTTTATCCGGCCCCAGCGCAGCACAGCGGACCTGGTGGTGAGCTTCTACCCGGGCCAGAA
CGGCCCCGATACCCAGCTCAACGTGCGGCTGGTGCTCAGACCGACCATTCCCCACCCGGACTTCGTGGATGTCATCGAGC
GCAGCGGCGCCCACACCCGCTCGGCGGTGCGCGTCGAACTGGACCGCGACATGGGCAAGCCCGTCGATGTGCTCGAAGTG
GACGGCCATGCCACCGACGAGCAGGTCAAAGAACTCCAGGATGTGCTCTGCGAAGAGATGGCCAACGGCTCGCAGCTGTG
CAATATCCCCGCGGACCTGGGCAAGGTGACCGGCACCACCGGCGAAACGCTGCAGAGCCATCCACTCGCCATCTCGCAGT
TGCTGATCACCTACCACATGCTCAAAGCCTCGCGGGGCGTCTACGTTTAG

Upstream 100 bases:

>100_bases
TGCCGGGGCGGGCTGACAAAAAGTCCGTCGTCCTACAACGGAAAAATATGTGACGGGGGTTCTAAAATCAAAACTACTTA
TCCTTAGCAGGGGAGGCCCC

Downstream 100 bases:

>100_bases
CCGCCCGCGACCGGCCCGTGTACAGATTGATAAACGGCCCGATGAACCGTTGCGCCCGGTGCGTTAGCCTTGTCTGTGGC
CAAAACGGACAGGCAAGGAG

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAQRPIILGIVGDSAAGKTTLTRGLAQILGPDNVTIICTDDYHRYDRKQRAELGITALHPDCNYLDIIQQHLALLRTGQP
ILKPIYNHKTGTFDPPEYIKPRNFVVVEGLLGFSTRGMRDCYDVKAYLAPPESLRTRWKIRRDTAKRGYSEEQVLGEMAK
REPDSEQFIRPQRSTADLVVSFYPGQNGPDTQLNVRLVLRPTIPHPDFVDVIERSGAHTRSAVRVELDRDMGKPVDVLEV
DGHATDEQVKELQDVLCEEMANGSQLCNIPADLGKVTGTTGETLQSHPLAISQLLITYHMLKASRGVYV

Sequences:

>Translated_309_residues
MAQRPIILGIVGDSAAGKTTLTRGLAQILGPDNVTIICTDDYHRYDRKQRAELGITALHPDCNYLDIIQQHLALLRTGQP
ILKPIYNHKTGTFDPPEYIKPRNFVVVEGLLGFSTRGMRDCYDVKAYLAPPESLRTRWKIRRDTAKRGYSEEQVLGEMAK
REPDSEQFIRPQRSTADLVVSFYPGQNGPDTQLNVRLVLRPTIPHPDFVDVIERSGAHTRSAVRVELDRDMGKPVDVLEV
DGHATDEQVKELQDVLCEEMANGSQLCNIPADLGKVTGTTGETLQSHPLAISQLLITYHMLKASRGVYV
>Mature_308_residues
AQRPIILGIVGDSAAGKTTLTRGLAQILGPDNVTIICTDDYHRYDRKQRAELGITALHPDCNYLDIIQQHLALLRTGQPI
LKPIYNHKTGTFDPPEYIKPRNFVVVEGLLGFSTRGMRDCYDVKAYLAPPESLRTRWKIRRDTAKRGYSEEQVLGEMAKR
EPDSEQFIRPQRSTADLVVSFYPGQNGPDTQLNVRLVLRPTIPHPDFVDVIERSGAHTRSAVRVELDRDMGKPVDVLEVD
GHATDEQVKELQDVLCEEMANGSQLCNIPADLGKVTGTTGETLQSHPLAISQLLITYHMLKASRGVYV

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=185, Percent_Identity=26.4864864864865, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI57863312, Length=185, Percent_Identity=26.4864864864865, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI18699734, Length=209, Percent_Identity=23.9234449760766, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI13899253, Length=211, Percent_Identity=24.6445497630332, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI87082034, Length=187, Percent_Identity=26.7379679144385, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=184, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539892, Length=184, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221458995, Length=240, Percent_Identity=24.1666666666667, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573516, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573514, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573512, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550449, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649624, Length=211, Percent_Identity=24.1706161137441, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 34539; Mature: 34408

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00567 PHOSPHORIBULOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRPIILGIVGDSAAGKTTLTRGLAQILGPDNVTIICTDDYHRYDRKQRAELGITALHP
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECC
DCNYLDIIQQHLALLRTGQPILKPIYNHKTGTFDPPEYIKPRNFVVVEGLLGFSTRGMRD
CCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCHH
CYDVKAYLAPPESLRTRWKIRRDTAKRGYSEEQVLGEMAKREPDSEQFIRPQRSTADLVV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEE
SFYPGQNGPDTQLNVRLVLRPTIPHPDFVDVIERSGAHTRSAVRVELDRDMGKPVDVLEV
EEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEE
DGHATDEQVKELQDVLCEEMANGSQLCNIPADLGKVTGTTGETLQSHPLAISQLLITYHM
CCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHH
LKASRGVYV
HHHCCCCCC
>Mature Secondary Structure 
AQRPIILGIVGDSAAGKTTLTRGLAQILGPDNVTIICTDDYHRYDRKQRAELGITALHP
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECC
DCNYLDIIQQHLALLRTGQPILKPIYNHKTGTFDPPEYIKPRNFVVVEGLLGFSTRGMRD
CCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCHH
CYDVKAYLAPPESLRTRWKIRRDTAKRGYSEEQVLGEMAKREPDSEQFIRPQRSTADLVV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEE
SFYPGQNGPDTQLNVRLVLRPTIPHPDFVDVIERSGAHTRSAVRVELDRDMGKPVDVLEV
EEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEE
DGHATDEQVKELQDVLCEEMANGSQLCNIPADLGKVTGTTGETLQSHPLAISQLLITYHM
CCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHH
LKASRGVYV
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]