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The map label for this gene is clpX

Identifier: 37523765

GI number: 37523765

Start: 4392091

End: 4393404

Strand: Direct

Name: clpX

Synonym: gvip552

Alternate gene names: 37523765

Gene position: 4392091-4393404 (Clockwise)

Preceding gene: 37523764

Following gene: 37523766

Centisome position: 94.27

GC content: 61.11

Gene sequence:

>1314_bases
ATGCCCAAGTACGACTCCCATCTCAAATGCTCCTTCTGCGGCAAGTCCCAGGAGCAGGTTCGAAAGCTCATCGCCGGGCC
GGGGGTATACATTTGCGACGAGTGCGTCGAACTGTGCAACGAGATCCTCGACGAGGAACTGTTTGAAGGGGCGACCCAGC
CCCAGCCCCAACCGACCAAGGTCAAAGCCTCGCGCTCCAGTCGCCGGGACACTTCCCTCAAGAAGATCCCCAAGCCGCAG
GAGATCAAGTCTTACCTCGACCAGCACGTCATCGGTCAGCAAGAGGCCAAGAAAATCCTCTCGGTGGCGGTCTACAACCA
CTACAAGCGCCTCAGCTCGAAGCTCGAAGAGAGTGGCGACGAGGTCGAAATTCAAAAATCCAACATTCTGCTCATCGGCC
CCACCGGCTGCGGCAAGACGCTCTTGGCCCAGACCCTGGCCGATTTGCTCGATGTGCCCTTCGCCATTGCCGATGCCACT
ACCCTCACCGAGGCGGGCTACGTGGGCGAGGATGTCGAGAACATCCTGCTGCGGTTGCTGCAGGTGGCCGACGGCGAGGT
CGAGCGCGCCCAGCGCGGCATCATCTACATCGACGAAATCGATAAGATTGCCCGCAAGTCCGAGAACCCTTCGATCACCC
GCGACGTGTCGGGCGAAGGCGTCCAGCAGGCGCTCCTCAAGATGCTCGAAGGCACCGTCGCCAACGTCCCTCCCCAGGGT
GGGCGCAAGCATCCCTACCAGGAATACATCCAGATCGACACGGCCAACATCCTGTTTGTCTGCGGAGGAGCGTTTGTCGG
TCTGGAGCGCGTCGTCGAGCAGCGCATCGGTAAGCGGGCGATGGGCTTTGTACAGGCGGGCGAGCCCCAGAAGCGCGAAC
AACGCTTGGTCGAATCGCTCAAGGCTCTCGAACCCGACGATCTGGTCAAATTCGGCCTGATTCCCGAATTTATCGGCCGC
ATTCCGATGGTGGCGGTGCTCGAACCCCTCGACGAGGAAGCCCTCATCGAGATTCTCACCGAACCCAAGAACGCCTTGCT
CAAGCAGTACCAGCGCCTGCTGCGCATGGACGGCGTCGAAATGGTCTTCGAACCCGACGCGATCAAGACCATCGCCCAGG
AAGCTTTCCGGCGCAAGACCGGGGCACGGGCTCTGCGGGGTATCGTCGAGGAGCTGATGCTCGAAGTGATGTACGAGGTG
CCCTCGCGCGCCGACATCCGCAAGTGCGTGATCACCCGCGAGATGGTCGAGAAGCGCTCCACCTCCGAGCTGCTGATTCT
GCCCAGTTCGCTGCCCAAACCCGAATCGGCCTGA

Upstream 100 bases:

>100_bases
TCGGGCGAAGACGCTCCCCCCGAAGTTGCCGCCGGGGCCACCGAGCCCGAGGCGCAACCCAACTCCTGAAACCTCGTTTC
CTCAACACCCAGGCTGCCCC

Downstream 100 bases:

>100_bases
TCCTCCTGTACAGCCTATCTGCAGAAGCGGGCTATCCAGCCCGCTTCGCTTATTTGGGGGCACCTACCCTGGCCAGGTTA
ACAATGTCAAAGATCTGGTC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILDEELFEGATQPQPQPTKVKASRSSRRDTSLKKIPKPQ
EIKSYLDQHVIGQQEAKKILSVAVYNHYKRLSSKLEESGDEVEIQKSNILLIGPTGCGKTLLAQTLADLLDVPFAIADAT
TLTEAGYVGEDVENILLRLLQVADGEVERAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQG
GRKHPYQEYIQIDTANILFVCGGAFVGLERVVEQRIGKRAMGFVQAGEPQKREQRLVESLKALEPDDLVKFGLIPEFIGR
IPMVAVLEPLDEEALIEILTEPKNALLKQYQRLLRMDGVEMVFEPDAIKTIAQEAFRRKTGARALRGIVEELMLEVMYEV
PSRADIRKCVITREMVEKRSTSELLILPSSLPKPESA

Sequences:

>Translated_437_residues
MPKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILDEELFEGATQPQPQPTKVKASRSSRRDTSLKKIPKPQ
EIKSYLDQHVIGQQEAKKILSVAVYNHYKRLSSKLEESGDEVEIQKSNILLIGPTGCGKTLLAQTLADLLDVPFAIADAT
TLTEAGYVGEDVENILLRLLQVADGEVERAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQG
GRKHPYQEYIQIDTANILFVCGGAFVGLERVVEQRIGKRAMGFVQAGEPQKREQRLVESLKALEPDDLVKFGLIPEFIGR
IPMVAVLEPLDEEALIEILTEPKNALLKQYQRLLRMDGVEMVFEPDAIKTIAQEAFRRKTGARALRGIVEELMLEVMYEV
PSRADIRKCVITREMVEKRSTSELLILPSSLPKPESA
>Mature_436_residues
PKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILDEELFEGATQPQPQPTKVKASRSSRRDTSLKKIPKPQE
IKSYLDQHVIGQQEAKKILSVAVYNHYKRLSSKLEESGDEVEIQKSNILLIGPTGCGKTLLAQTLADLLDVPFAIADATT
LTEAGYVGEDVENILLRLLQVADGEVERAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQGG
RKHPYQEYIQIDTANILFVCGGAFVGLERVVEQRIGKRAMGFVQAGEPQKREQRLVESLKALEPDDLVKFGLIPEFIGRI
PMVAVLEPLDEEALIEILTEPKNALLKQYQRLLRMDGVEMVFEPDAIKTIAQEAFRRKTGARALRGIVEELMLEVMYEVP
SRADIRKCVITREMVEKRSTSELLILPSSLPKPESA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=337, Percent_Identity=49.2581602373887, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1786642, Length=414, Percent_Identity=60.1449275362319, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=43.8095238095238, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982908, Length=312, Percent_Identity=44.5512820512821, Blast_Score=274, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71982905, Length=312, Percent_Identity=44.5512820512821, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=436, Percent_Identity=37.3853211009174, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71988660, Length=288, Percent_Identity=37.5, Blast_Score=184, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6319704, Length=414, Percent_Identity=38.8888888888889, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24648289, Length=325, Percent_Identity=47.6923076923077, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24648291, Length=325, Percent_Identity=47.6923076923077, Blast_Score=295, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_GLOVI (Q7NDN9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927142.1
- ProteinModelPortal:   Q7NDN9
- GeneID:   2602599
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.4196
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   GVIO251221:GLR4196-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 48737; Mature: 48606

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILDEELFEGATQPQPQPTK
CCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VKASRSSRRDTSLKKIPKPQEIKSYLDQHVIGQQEAKKILSVAVYNHYKRLSSKLEESGD
CCCHHHHHHCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVEIQKSNILLIGPTGCGKTLLAQTLADLLDVPFAIADATTLTEAGYVGEDVENILLRLL
EEEEEECCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
QVADGEVERAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQG
HHHCCHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCC
GRKHPYQEYIQIDTANILFVCGGAFVGLERVVEQRIGKRAMGFVQAGEPQKREQRLVESL
CCCCCHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KALEPDDLVKFGLIPEFIGRIPMVAVLEPLDEEALIEILTEPKNALLKQYQRLLRMDGVE
HCCCHHHHHHHHCHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
MVFEPDAIKTIAQEAFRRKTGARALRGIVEELMLEVMYEVPSRADIRKCVITREMVEKRS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TSELLILPSSLPKPESA
CCCEEEECCCCCCCCCC
>Mature Secondary Structure 
PKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVELCNEILDEELFEGATQPQPQPTK
CCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VKASRSSRRDTSLKKIPKPQEIKSYLDQHVIGQQEAKKILSVAVYNHYKRLSSKLEESGD
CCCHHHHHHCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVEIQKSNILLIGPTGCGKTLLAQTLADLLDVPFAIADATTLTEAGYVGEDVENILLRLL
EEEEEECCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
QVADGEVERAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQG
HHHCCHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCC
GRKHPYQEYIQIDTANILFVCGGAFVGLERVVEQRIGKRAMGFVQAGEPQKREQRLVESL
CCCCCHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KALEPDDLVKFGLIPEFIGRIPMVAVLEPLDEEALIEILTEPKNALLKQYQRLLRMDGVE
HCCCHHHHHHHHCHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
MVFEPDAIKTIAQEAFRRKTGARALRGIVEELMLEVMYEVPSRADIRKCVITREMVEKRS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TSELLILPSSLPKPESA
CCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292