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The map label for this gene is shc [H]

Identifier: 37523626

GI number: 37523626

Start: 4251199

End: 4253112

Strand: Direct

Name: shc [H]

Synonym: gvip545

Alternate gene names: 37523626

Gene position: 4251199-4253112 (Clockwise)

Preceding gene: 37523623

Following gene: 37523627

Centisome position: 91.25

GC content: 66.56

Gene sequence:

>1914_bases
ATGCAAGTCCAACCGCGCATCGAAAAAAAGCACCTAGATAGTGCGATCGAAGCGAGCCAGGCGTACCTGTTGGCTCGGCA
GTACTCCCCGGGCTACTGGTGGGCCGAACTGGAGTCGAACGTGTCGATGACCGCCGAGGTGGTCCTCCTGCACAAAATCT
GGCGCACGGACACCGGCCGTCCCCTCGCCAAGGCGACCGCCCACCTGCTCGCTGAGCAGCGCGCCCACGGCGGTTGGGAG
CTGTTCTACGGCGACGGCGGCGATCTGAACACATCGATCGAGGCGTACATGGCCCTGAAGCTGCTGGGCCTCACCGCCGA
TCACCCCGCCCTGGCGCGCGCCCGCGCATTTATCCTCGCCAAAGGCGGCATCAGCCGCGCGCGCATCTTCACCAAGATCC
ATCTGGCGCTCATCGGCTGCTACGACTGGCGCGGCGTCCCGTCGATTCCGCCCTGGGTGATGCTGCTACCTGAGGCCTTT
CCGGTCAATATCTACGAGATGTCCAGTTGGGCGCGCGGCAGCACGGTACCGCTGCTGATCGTCTTCGACCGCAAGCCGGT
CTTTGCCGTCGAGCCGGCCATTACCCTCGACGAGCTATTTGTCGAAGGACGCGCCCAGGCCCGCTTCGATCTGCCCCGCA
GTTCGAGCGACTGGTGGGCGAATCTGTTTGTCGATCTCGACTGGGGCTTCAAGCTCGCCGAGAGCCTGGGGGCGGTTCCC
CTGCGCGAAGAAGGGCTGAAAGCCGCCGAGCGCTGGGTGCTCGAGCGCCAGGAGGCGACCGGTGATTGGGGTGGGATCAT
CCCGGCGATGCTCAATTCGCTGCTGGCGCTGCGCTGCCTCGATTACGATCCCCACGACCCGGTGGTCGAGCGGGGAATGG
CCGCGGTCGATCGCTTCGCCATCGAGACCGAAAGCACCTATCGCCTGCAGCCGTGCGTCTCCCCCGTCTGGGACACAGCC
CTGACCATGCGCGCCCTGGTCGATTCGGGATTGCCCCCGGATCACCCGGCCCTCGCGGCGGCCGGCACCTGGCTGCTGAA
GAAGCAGATCCTCGACTACGGCGATTGGGCGGTCAAAAACCGGACCGGTCCGCCCGGCGGCTGGGCTTTCGAGTTCGACA
ACCGCTTCTACCCGGATGTGGACGACACGGCCGTCGTGGTGATGGCCCTCGACGCCGTGCGGCTGGCCGACGAGACCGCC
AAGGGCCAGGCGATCGCCCGGGCGGTGTGCTGGGTGGCCTCGATGCAGTGCCGGGGCGGGGGCTGGGCGGCCTTCGATAT
CGACAACGACGCCCACTGGCTCAACAGCCTTCCTTACGCCGATCTCAAGGCGATGATCGACCCGAACACCGCCGATGTCA
CCGCCCGCGTCCTCGAGATGTACGGCCGCTGCCGCCTGATTCCCGCGGCCGCCGGTGCCCAGCGCGCCCTCGATTATCTG
CGGCGCACCCAGGAGCCGGAGGGCTGCTGGTTCGGCCGCTGGGGGGTGAATTATCTCTATGGCACCAGCGGCGTGCTCTC
GGCCCTGGCCGCTTTCGCCCCGGCCGAACGCACGGCCATCGAGCGCGCTGCCGCCTGGCTGCGGGGTTGCCAGAACACCG
ACGGCGGTTGGGGGGAAACCTGCGGGAGTTATGTCGATCGCACTTTGATGGGCCAGGGACCGAGCACCGCTTCCCAGACT
GCCTGGGCGTTGCTCGGCCTCATCGACGCGAGCCGGGTGGCCCGCTTCAGCGACAGCAGCGCCCTCGAACGCGGCCTTGC
CTATCTGGTGGAAACCCAAAAAGCGGACGGCAGCTGGGACGAGCCCTACTTCACCGGCACCGGTTTTCCGGGGCATTTTT
ACCTGAAGTATCACCTCTATCAGCAGCACTTTCCCCTGAGTGCCCTCGGCCGCTACCGCCGCCTGCTCAGTTAA

Upstream 100 bases:

>100_bases
GAGCCAGGCCCGCCAACCCAGAAAAACTATCCACCGCAAGCATTCCCACTGTTCTAGAACCGTACAATAACTGCGACAGG
AGTGAACGGAACAGTTAAAA

Downstream 100 bases:

>100_bases
ATGCGGCCGGCAAGCCCGGCGCGAGTTCACTGCTCAATCTGGCAGAAACGAACCGGTTTTGTTGCGATTGTGTCGCGGCT
GAGGTGGTTGAGCGAAGGTC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MQVQPRIEKKHLDSAIEASQAYLLARQYSPGYWWAELESNVSMTAEVVLLHKIWRTDTGRPLAKATAHLLAEQRAHGGWE
LFYGDGGDLNTSIEAYMALKLLGLTADHPALARARAFILAKGGISRARIFTKIHLALIGCYDWRGVPSIPPWVMLLPEAF
PVNIYEMSSWARGSTVPLLIVFDRKPVFAVEPAITLDELFVEGRAQARFDLPRSSSDWWANLFVDLDWGFKLAESLGAVP
LREEGLKAAERWVLERQEATGDWGGIIPAMLNSLLALRCLDYDPHDPVVERGMAAVDRFAIETESTYRLQPCVSPVWDTA
LTMRALVDSGLPPDHPALAAAGTWLLKKQILDYGDWAVKNRTGPPGGWAFEFDNRFYPDVDDTAVVVMALDAVRLADETA
KGQAIARAVCWVASMQCRGGGWAAFDIDNDAHWLNSLPYADLKAMIDPNTADVTARVLEMYGRCRLIPAAAGAQRALDYL
RRTQEPEGCWFGRWGVNYLYGTSGVLSALAAFAPAERTAIERAAAWLRGCQNTDGGWGETCGSYVDRTLMGQGPSTASQT
AWALLGLIDASRVARFSDSSALERGLAYLVETQKADGSWDEPYFTGTGFPGHFYLKYHLYQQHFPLSALGRYRRLLS

Sequences:

>Translated_637_residues
MQVQPRIEKKHLDSAIEASQAYLLARQYSPGYWWAELESNVSMTAEVVLLHKIWRTDTGRPLAKATAHLLAEQRAHGGWE
LFYGDGGDLNTSIEAYMALKLLGLTADHPALARARAFILAKGGISRARIFTKIHLALIGCYDWRGVPSIPPWVMLLPEAF
PVNIYEMSSWARGSTVPLLIVFDRKPVFAVEPAITLDELFVEGRAQARFDLPRSSSDWWANLFVDLDWGFKLAESLGAVP
LREEGLKAAERWVLERQEATGDWGGIIPAMLNSLLALRCLDYDPHDPVVERGMAAVDRFAIETESTYRLQPCVSPVWDTA
LTMRALVDSGLPPDHPALAAAGTWLLKKQILDYGDWAVKNRTGPPGGWAFEFDNRFYPDVDDTAVVVMALDAVRLADETA
KGQAIARAVCWVASMQCRGGGWAAFDIDNDAHWLNSLPYADLKAMIDPNTADVTARVLEMYGRCRLIPAAAGAQRALDYL
RRTQEPEGCWFGRWGVNYLYGTSGVLSALAAFAPAERTAIERAAAWLRGCQNTDGGWGETCGSYVDRTLMGQGPSTASQT
AWALLGLIDASRVARFSDSSALERGLAYLVETQKADGSWDEPYFTGTGFPGHFYLKYHLYQQHFPLSALGRYRRLLS
>Mature_637_residues
MQVQPRIEKKHLDSAIEASQAYLLARQYSPGYWWAELESNVSMTAEVVLLHKIWRTDTGRPLAKATAHLLAEQRAHGGWE
LFYGDGGDLNTSIEAYMALKLLGLTADHPALARARAFILAKGGISRARIFTKIHLALIGCYDWRGVPSIPPWVMLLPEAF
PVNIYEMSSWARGSTVPLLIVFDRKPVFAVEPAITLDELFVEGRAQARFDLPRSSSDWWANLFVDLDWGFKLAESLGAVP
LREEGLKAAERWVLERQEATGDWGGIIPAMLNSLLALRCLDYDPHDPVVERGMAAVDRFAIETESTYRLQPCVSPVWDTA
LTMRALVDSGLPPDHPALAAAGTWLLKKQILDYGDWAVKNRTGPPGGWAFEFDNRFYPDVDDTAVVVMALDAVRLADETA
KGQAIARAVCWVASMQCRGGGWAAFDIDNDAHWLNSLPYADLKAMIDPNTADVTARVLEMYGRCRLIPAAAGAQRALDYL
RRTQEPEGCWFGRWGVNYLYGTSGVLSALAAFAPAERTAIERAAAWLRGCQNTDGGWGETCGSYVDRTLMGQGPSTASQT
AWALLGLIDASRVARFSDSSALERGLAYLVETQKADGSWDEPYFTGTGFPGHFYLKYHLYQQHFPLSALGRYRRLLS

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=609, Percent_Identity=25.944170771757, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI47933397, Length=609, Percent_Identity=25.944170771757, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI224177558, Length=609, Percent_Identity=25.944170771757, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI224177556, Length=581, Percent_Identity=25.9896729776248, Blast_Score=140, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321863, Length=603, Percent_Identity=23.2172470978441, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 70572; Mature: 70572

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVQPRIEKKHLDSAIEASQAYLLARQYSPGYWWAELESNVSMTAEVVLLHKIWRTDTGR
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
PLAKATAHLLAEQRAHGGWELFYGDGGDLNTSIEAYMALKLLGLTADHPALARARAFILA
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEE
KGGISRARIFTKIHLALIGCYDWRGVPSIPPWVMLLPEAFPVNIYEMSSWARGSTVPLLI
CCCCCHHHHHHHEEEHHEEEECCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCEEEE
VFDRKPVFAVEPAITLDELFVEGRAQARFDLPRSSSDWWANLFVDLDWGFKLAESLGAVP
EECCCCCEEECCCCCHHHHHHCCCCCEEECCCCCCCCCEEEEEEEECCCHHHHHHHCCCC
LREEGLKAAERWVLERQEATGDWGGIIPAMLNSLLALRCLDYDPHDPVVERGMAAVDRFA
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IETESTYRLQPCVSPVWDTALTMRALVDSGLPPDHPALAAAGTWLLKKQILDYGDWAVKN
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
RTGPPGGWAFEFDNRFYPDVDDTAVVVMALDAVRLADETAKGQAIARAVCWVASMQCRGG
CCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GWAAFDIDNDAHWLNSLPYADLKAMIDPNTADVTARVLEMYGRCRLIPAAAGAQRALDYL
CEEEEECCCCHHHHHCCCHHHHHHEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
RRTQEPEGCWFGRWGVNYLYGTSGVLSALAAFAPAERTAIERAAAWLRGCQNTDGGWGET
HHCCCCCCCEEECCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHH
CGSYVDRTLMGQGPSTASQTAWALLGLIDASRVARFSDSSALERGLAYLVETQKADGSWD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCC
EPYFTGTGFPGHFYLKYHLYQQHFPLSALGRYRRLLS
CCEEECCCCCCEEEEEEEEEHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQVQPRIEKKHLDSAIEASQAYLLARQYSPGYWWAELESNVSMTAEVVLLHKIWRTDTGR
CCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
PLAKATAHLLAEQRAHGGWELFYGDGGDLNTSIEAYMALKLLGLTADHPALARARAFILA
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEEEE
KGGISRARIFTKIHLALIGCYDWRGVPSIPPWVMLLPEAFPVNIYEMSSWARGSTVPLLI
CCCCCHHHHHHHEEEHHEEEECCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCEEEE
VFDRKPVFAVEPAITLDELFVEGRAQARFDLPRSSSDWWANLFVDLDWGFKLAESLGAVP
EECCCCCEEECCCCCHHHHHHCCCCCEEECCCCCCCCCEEEEEEEECCCHHHHHHHCCCC
LREEGLKAAERWVLERQEATGDWGGIIPAMLNSLLALRCLDYDPHDPVVERGMAAVDRFA
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IETESTYRLQPCVSPVWDTALTMRALVDSGLPPDHPALAAAGTWLLKKQILDYGDWAVKN
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
RTGPPGGWAFEFDNRFYPDVDDTAVVVMALDAVRLADETAKGQAIARAVCWVASMQCRGG
CCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GWAAFDIDNDAHWLNSLPYADLKAMIDPNTADVTARVLEMYGRCRLIPAAAGAQRALDYL
CEEEEECCCCHHHHHCCCHHHHHHEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
RRTQEPEGCWFGRWGVNYLYGTSGVLSALAAFAPAERTAIERAAAWLRGCQNTDGGWGET
HHCCCCCCCEEECCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHH
CGSYVDRTLMGQGPSTASQTAWALLGLIDASRVARFSDSSALERGLAYLVETQKADGSWD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCC
EPYFTGTGFPGHFYLKYHLYQQHFPLSALGRYRRLLS
CCEEECCCCCCEEEEEEEEEHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]