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The map label for this gene is sdhA [H]

Identifier: 37522557

GI number: 37522557

Start: 3187499

End: 3189232

Strand: Direct

Name: sdhA [H]

Synonym: glr2988

Alternate gene names: 37522557

Gene position: 3187499-3189232 (Clockwise)

Preceding gene: 37522555

Following gene: 37522562

Centisome position: 68.42

GC content: 65.28

Gene sequence:

>1734_bases
ATGCTGGAGTACGACATTGTGATCGTCGGCGGGGGACTGGCCGGTTCCCGCGCCGCCGTCGAGATTGCCCGCACCGACAA
CCGCCTGAAAGTGGCCCTCGTCTCGAAGGTGCACCCGATTAGAAGCCATTCGGTGGCCGCTCAGGGGGGGATCGCCGCTG
CCCTGCAAAACGTCGATCCGCAGGACAACTGGCTTACCCACGCCTTCGATACCGTTAAGGGGGCCGATTACCTGGCGGAC
CAGGACGCCGTGGCCGTGCTCACCCAGCAGGCGCCCCAGGTGATTATCGATCTCGAGCACATGGGGGTGCTCTTCTCGCG
GCTACCGGACGGGCGCATCGCCCAGCGGCCCTTCGGCGGGCACACCCACCAGCGCACCTGCTACGCCGCCGACAAGACCG
GACACGCCATCCTGCACGAACTGGTGAGCCGGTTGTTCCAGTACAAAGTGCCCATTTTCGAAGAGTGGTACGTCCTGGAG
CTGATCGTGGAGGAAGGCGAGGCACGGGGGTTGGTGATGTTCCACATTCCCACCGGCCGCATCGAGGTGGTGCGCGCCAA
GGCAATTTTGTTTGCCACCGGCGGCTATGGCCGCGTCTTCAACACCACTTCCAACGACTACGCCTCCACCGGCGACGGGC
TGTGCCTTGCGGCCATGGCCGGTCTGCCGCTCCAGGACATGGAATTTGTACAGTTTCATCCGACTGGACTGTACCCGGTG
GGGGTGCTCATCTCCGAGGCGGTGCGCGGCGAGGGTGCTCACCTGATCAACGACGCGGGTGAGCGCTTTATGGCGGGTTA
CGCCCCGAGCCGCATGGAACTGGCCCCCCGCGACATCACCAGCCGCGCCATCGCCACCGAAATTCGCGAAGGCCGCGGCG
TCGGCGGCGGACGTTACGTCCACCTCGATCTCAGGCACATGGGCAAAGAAAAGATCCTGGAGCGGGTGCCCTTCGCCCAC
GACGAAGCCCTGCGCCACCTGGGCATCGACGTGGTCTACGAACCGATGCCCGTGCGCCCGACCGTGCACTACTCGATGGG
GGGGATTCCCACCACCGTCGATTGCCAGGCGCTGGCCGCCCACGGCCAGGTGATGGAAGGCTTCTTTGCCGCCGGGGAGT
GCTCGTGCGTCTCGGTGCACGGCGCCAACCGCCTGGGGAGCAACTCGCTGCTGGAGTGCGTGGTTTACGGGGCGCGGGCG
GGGGCGTCCCTGGCCCGCTACGTGCAGGATCGCCGCTTGCCCCATGTGGACGAAGCGCGCCACCGCCGGGTGGCGGAGCA
AGGCATCCAGAATCTGCTCGACCAGCCGGGCAGTTTGCGTATCGACGCGCTGCGCCGCGAGTTCCAGGACACCCTCACCG
ACCACTGCTCGATCTTTCGCGACGAGCAGATTCTCAAGACCGGTCTGGAGAAAATTCAACAGCTCAAAGCCCGCTACGGC
GACATTCGCCTGGACGACAAAGGCAAACTTTACAACACCGAGATCACCGAGGCTTTTGAGTTGCGCAGCCTGATCACCGT
GGGCGAGATCATCGTGGCAAGCGCCCTGGAGCGGCGCGAATCGCGCGGCGCCCACTCCCGCAGCGACTACCCCGAGCGCA
ACGACGGCGAGTATCTCAAGCACACCCTCGCCTACCGCGAAGGGGACGCCCTGCGCATCGACTACCGGCCGGTGGATCTG
AGCTTGCAGGCGGTCGATCCTGAGCGCTTCACCCCCCAGGCGCGCAAATACTAG

Upstream 100 bases:

>100_bases
TCGGGCGGGCCATCGGCTCTATCCGCGGCAGGAGCTGCATCCGGGGCCGCGGGCCGGGGCCGGTGTGTAACGATGGTGAT
CAGACACACCCGAGCGCGCC

Downstream 100 bases:

>100_bases
AGCAGGTGTCAGGTGTCAGGGTAAAAACCGCTGCCTGTCCAGGTTTCCAGTCCTACTTCTCGGTGCAGCGCACACGCAGA
ACTAGGGGTCGTGGCACGGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDPQDNWLTHAFDTVKGADYLAD
QDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGGHTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLE
LIVEEGEARGLVMFHIPTGRIEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYVHLDLRHMGKEKILERVPFAH
DEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAAHGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARA
GASLARYVQDRRLPHVDEARHRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYG
DIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLKHTLAYREGDALRIDYRPVDL
SLQAVDPERFTPQARKY

Sequences:

>Translated_577_residues
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDPQDNWLTHAFDTVKGADYLAD
QDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGGHTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLE
LIVEEGEARGLVMFHIPTGRIEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYVHLDLRHMGKEKILERVPFAH
DEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAAHGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARA
GASLARYVQDRRLPHVDEARHRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYG
DIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLKHTLAYREGDALRIDYRPVDL
SLQAVDPERFTPQARKY
>Mature_577_residues
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDPQDNWLTHAFDTVKGADYLAD
QDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGGHTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLE
LIVEEGEARGLVMFHIPTGRIEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYVHLDLRHMGKEKILERVPFAH
DEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAAHGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARA
GASLARYVQDRRLPHVDEARHRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYG
DIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLKHTLAYREGDALRIDYRPVDL
SLQAVDPERFTPQARKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=583, Percent_Identity=42.0240137221269, Blast_Score=450, Evalue=1e-126,
Organism=Escherichia coli, GI1786942, Length=596, Percent_Identity=42.7852348993289, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1790597, Length=551, Percent_Identity=41.016333938294, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=34.6014492753623, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17550100, Length=596, Percent_Identity=40.1006711409396, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17505833, Length=584, Percent_Identity=40.7534246575342, Blast_Score=440, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71986328, Length=429, Percent_Identity=26.1072261072261, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322416, Length=575, Percent_Identity=43.8260869565217, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=42.6890756302521, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320788, Length=484, Percent_Identity=28.099173553719, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137288, Length=581, Percent_Identity=39.2426850258176, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24655642, Length=581, Percent_Identity=39.2426850258176, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24655647, Length=581, Percent_Identity=39.2426850258176, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24663005, Length=589, Percent_Identity=38.2003395585739, Blast_Score=401, Evalue=1e-112,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63846; Mature: 63846

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDP
CCEEEEEEEECCCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCCCHHCCCHHHHHHCCCC
QDNWLTHAFDTVKGADYLADQDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGG
CCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCC
HTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLELIVEEGEARGLVMFHIPTGR
CCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCCCEEEEEECCCC
IEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPV
EEEEEEEEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYV
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
HLDLRHMGKEKILERVPFAHDEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAA
EEEHHHCCHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHH
HGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARAGASLARYVQDRRLPHVDEAR
CCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHH
HRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYG
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLK
CEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
HTLAYREGDALRIDYRPVDLSLQAVDPERFTPQARKY
HHHHHCCCCEEEEEEEEEEEEEEECCCHHCCCHHCCC
>Mature Secondary Structure
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDP
CCEEEEEEEECCCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCCCHHCCCHHHHHHCCCC
QDNWLTHAFDTVKGADYLADQDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGG
CCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCC
HTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLELIVEEGEARGLVMFHIPTGR
CCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCCCEEEEEECCCC
IEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPV
EEEEEEEEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYV
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
HLDLRHMGKEKILERVPFAHDEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAA
EEEHHHCCHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHH
HGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARAGASLARYVQDRRLPHVDEAR
CCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHH
HRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYG
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLK
CEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
HTLAYREGDALRIDYRPVDLSLQAVDPERFTPQARKY
HHHHHCCCCEEEEEEEEEEEEEEECCCHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA