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The map label for this gene is alsR [H]

Identifier: 37522555

GI number: 37522555

Start: 3186104

End: 3186988

Strand: Direct

Name: alsR [H]

Synonym: glr2986

Alternate gene names: 37522555

Gene position: 3186104-3186988 (Clockwise)

Preceding gene: 37522550

Following gene: 37522557

Centisome position: 68.39

GC content: 64.29

Gene sequence:

>885_bases
ATGGAATTTCACCACCTGCGCTACTTTGTGGCCGTGGCTGAGGAGTTGCACTTCGGCCGGGCAGCACAGCGGTTGCACAT
CACCCAGCCGGCCCTGAGCAAGCAGATCCGCAGCCTCGAAGCAGAATTGGGCCTTCAGCTTTTTTCGAGAACCCAGCGCC
GGGTCCAGCTCACCCGGGCTGGACTGGTCTTTCTTGAGCAAGCCCGACAGTTGCTCCATCAGGCCGACGCGGCACTGCAG
CTTGCCAGGCGCACCGCGCGCGGGGAAACGGGCCAGCTGTCGCTCGGATTTACCGCCTCGGCGCTGCAGAGCGTTCTGCC
CCGGATCGTGCGCGTCTTTCGCGAGCGTTATCCGGCGGTAGAGCTCAGCATGACGGAGCTATGTACCGAAGATCAGGTTG
AGGCGTTGCTCGGGCATCGAGTCGATGTGGCCTTCCTCCACCCTCCCATGCGCTCGCCCGCCGTGCAGCTGCAACCCTTG
GGCGAGGAAAATTTCGTCGCCGTCTTTGCCGAGGATCATCCGCTGCTTGCCTGTGGCCGGATTTCCCTGCGGGCTCTGGC
GGATGAAGCGTTCATCATTCATCCCCGCCAGGAAGGACCGGTGCTCTACGACCAGTTCTTCGAGCTGTGCGCGCGGATGG
GTTTTCGCCCCAAAGTGGTCCGGGAGGTGACGACGCACCAGAACAGGATCGGCCTGGTGGCGGCGGGCATGGGCATCACT
TTCCTGCCGGAGAGCCTGCAAGGGCAGGCCGGGGCCGGGGTGGCTTGCCGGCCGCTGGCGGATGCGGCTGCGAGGCTGGT
CCTGGCCGCCGCCTGGCACCAGGACAACACTTCGCCCATCCTGGGTCATTTTCTGACGGTCGCCAAAGCAGTTGCAGACC
TGTAG

Upstream 100 bases:

>100_bases
ACCCCCACCGCGACGCTTTAGCCTCAAGCTAAGCCGACGGCCTTGCGGCTGTCCAAGGCGGATTTGGTGCTATCTTCATA
ACCTGCGGTTATGAATCGAA

Downstream 100 bases:

>100_bases
CCTTCCTTAGTGTGGGGCCACCCATTTCAATCCGACGATGCCCGCGACGATGAGGCCGATGCAGGCAAGGCGCAGGGCGC
TTGCCGATTCGCCGAACAAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEFHHLRYFVAVAEELHFGRAAQRLHITQPALSKQIRSLEAELGLQLFSRTQRRVQLTRAGLVFLEQARQLLHQADAALQ
LARRTARGETGQLSLGFTASALQSVLPRIVRVFRERYPAVELSMTELCTEDQVEALLGHRVDVAFLHPPMRSPAVQLQPL
GEENFVAVFAEDHPLLACGRISLRALADEAFIIHPRQEGPVLYDQFFELCARMGFRPKVVREVTTHQNRIGLVAAGMGIT
FLPESLQGQAGAGVACRPLADAAARLVLAAAWHQDNTSPILGHFLTVAKAVADL

Sequences:

>Translated_294_residues
MEFHHLRYFVAVAEELHFGRAAQRLHITQPALSKQIRSLEAELGLQLFSRTQRRVQLTRAGLVFLEQARQLLHQADAALQ
LARRTARGETGQLSLGFTASALQSVLPRIVRVFRERYPAVELSMTELCTEDQVEALLGHRVDVAFLHPPMRSPAVQLQPL
GEENFVAVFAEDHPLLACGRISLRALADEAFIIHPRQEGPVLYDQFFELCARMGFRPKVVREVTTHQNRIGLVAAGMGIT
FLPESLQGQAGAGVACRPLADAAARLVLAAAWHQDNTSPILGHFLTVAKAVADL
>Mature_294_residues
MEFHHLRYFVAVAEELHFGRAAQRLHITQPALSKQIRSLEAELGLQLFSRTQRRVQLTRAGLVFLEQARQLLHQADAALQ
LARRTARGETGQLSLGFTASALQSVLPRIVRVFRERYPAVELSMTELCTEDQVEALLGHRVDVAFLHPPMRSPAVQLQPL
GEENFVAVFAEDHPLLACGRISLRALADEAFIIHPRQEGPVLYDQFFELCARMGFRPKVVREVTTHQNRIGLVAAGMGIT
FLPESLQGQAGAGVACRPLADAAARLVLAAAWHQDNTSPILGHFLTVAKAVADL

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=280, Percent_Identity=37.8571428571429, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=34.1296928327645, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI2367136, Length=260, Percent_Identity=37.3076923076923, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=32.5102880658436, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI157672245, Length=245, Percent_Identity=31.8367346938775, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693105, Length=254, Percent_Identity=30.7086614173228, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=29.9595141700405, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787530, Length=268, Percent_Identity=29.8507462686567, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=30.1587301587302, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787601, Length=262, Percent_Identity=29.0076335877863, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787806, Length=278, Percent_Identity=26.978417266187, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790262, Length=246, Percent_Identity=30.8943089430894, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788481, Length=197, Percent_Identity=29.9492385786802, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=26.8, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789173, Length=186, Percent_Identity=32.7956989247312, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082132, Length=259, Percent_Identity=29.3436293436293, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789506, Length=275, Percent_Identity=22.9090909090909, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789204, Length=262, Percent_Identity=25.9541984732824, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786713, Length=248, Percent_Identity=28.2258064516129, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI145693193, Length=247, Percent_Identity=27.9352226720648, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788296, Length=242, Percent_Identity=23.9669421487603, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081904, Length=202, Percent_Identity=26.2376237623762, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787589, Length=124, Percent_Identity=34.6774193548387, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082024, Length=167, Percent_Identity=28.1437125748503, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787949, Length=298, Percent_Identity=26.8456375838926, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=110, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32527; Mature: 32527

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFHHLRYFVAVAEELHFGRAAQRLHITQPALSKQIRSLEAELGLQLFSRTQRRVQLTRA
CCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVFLEQARQLLHQADAALQLARRTARGETGQLSLGFTASALQSVLPRIVRVFRERYPAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCE
ELSMTELCTEDQVEALLGHRVDVAFLHPPMRSPAVQLQPLGEENFVAVFAEDHPLLACGR
EEHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCEEEECC
ISLRALADEAFIIHPRQEGPVLYDQFFELCARMGFRPKVVREVTTHQNRIGLVAAGMGIT
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCE
FLPESLQGQAGAGVACRPLADAAARLVLAAAWHQDNTSPILGHFLTVAKAVADL
ECCHHHCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFHHLRYFVAVAEELHFGRAAQRLHITQPALSKQIRSLEAELGLQLFSRTQRRVQLTRA
CCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVFLEQARQLLHQADAALQLARRTARGETGQLSLGFTASALQSVLPRIVRVFRERYPAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCE
ELSMTELCTEDQVEALLGHRVDVAFLHPPMRSPAVQLQPLGEENFVAVFAEDHPLLACGR
EEHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCEEEECC
ISLRALADEAFIIHPRQEGPVLYDQFFELCARMGFRPKVVREVTTHQNRIGLVAAGMGIT
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCE
FLPESLQGQAGAGVACRPLADAAARLVLAAAWHQDNTSPILGHFLTVAKAVADL
ECCHHHCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]