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The map label for this gene is serA [H]

Identifier: 37521708

GI number: 37521708

Start: 2289707

End: 2291287

Strand: Direct

Name: serA [H]

Synonym: gvip294

Alternate gene names: 37521708

Gene position: 2289707-2291287 (Clockwise)

Preceding gene: 37521707

Following gene: 37521709

Centisome position: 49.15

GC content: 64.64

Gene sequence:

>1581_bases
ATGCCCAAGGTGCTTGTCAGTGACGCGATCGACCAGGCTGGTATCGAAATTCTCACCCAGGTCGCTCAAGTAACTTACGA
GCCGGATCTCAGCCCGGCGACGTTGCTTGAGACCATTCCCCAGTACGACGCTTTGATGATCCGCTCGGGCACCAAGGTGA
CCGCCCTGGTGATCGAAGCGGCCCAGCGCCTGCGGATCATCGGCCGCGCCGGGGTGGGTGTCGACAATGTCGATCTGCAG
GCTGCCACCCGCAAGGGGATCGTCGTGGTCAACTCCCCCGAGGGCAACACGATCGCCGCCGCCGAGCACGCCATCGCCTT
GATGATGAGCCTGTCGCGCCACGTGGGCGAAGCGAACGCCTCACTAAAAGCCGGCCAGTGGAAGCGCTCGCAATTTATCG
GCGTCGAAGTCTACAAAAAGACGATCGGCGTGGTGGGCCTGGGCCGCATCGGCTCGCATGTGACGCGGGTGGCGCGGGCA
CTCGGCATGCAGATCGTCGCCTTCGACCCGTATATTTCCGCCGAGCGCGCCCAGCAGCTGGGGGCACGCCTGGTCGATCT
GGAACAACTGTTTCACGAGGCCGACTACATCACGCTGCATGTGCCGCGCACGCCGGAGACCACCCACCTCATCAACGAGA
AGACCCTCGCCTCGATGAAGCCCACGGCCCGGATCATCAACTGTGCCCGCGGCGGCCTCATCGACGAGCAGGCGCTTTAT
GTCGCCCTCAAGGAAGGCCGCATCGCCGGGGCCGCCCTCGATGTCTTCGAGAACGAACCGCTCGGCGAATCGCCCCTGTG
CGCCCTCGGGCGCGAGGTGATCCTCACGCCCCACCTGGGTGCTTCGACCGAAGAGGCCCAGACCAACGTCGCCATTGATG
TGGCCGAGCAGATTCGCGATGTGCTTCTGGGTCTACCCGCCCGCACGGCGGTCAACATCCCAGGCCTGCGAGCCGAGGTG
CTGCAGGAACTGAAGCCCTATCTGGAACTGGCCGACACCCTGGGCAACCTTGTGGGCCAACTGGCCGGCGGCCGAGTGGA
TGCCCTTGACATTCGCCTGCAGGGCATTCTCGCGGCTAAAGACGCCCAGCCCATTGTCGTGGCCGCCCTCAAGGGCCTGC
TCACCCCGGCGCTGCGCGAGCGGGTCAACTTCGTCAACGCGCTGCTTGAGGCCAAGGAGCGGGGCATTCGGGTGACCGAG
ACGCGCGATTCGGCCTTCGCCGATTACGCGGGCTCGATCCGCCTGGAGGCGCGCGGCCCGGAGGGCGAGCGCTCCGTCAC
AGGCGCACTTTTGGCTGAGGACGAACTGCGCATCACCAACATCGACGAATTTCCGATCAGCGTCGCCCCGAGCCGCTACA
TGCTCATCACCCTGCACCGCGACATGCCGGGGATCATCGGCAAGGTGGGTTCGTTTCTGGGCTCCTACAACGTCAACATC
GCCGGCATGCAGGTGGGTCGCAAACTGGTGCGCGGCGACGCGGTGATGATGGTCTCCCTCGACGACCCGCTGCCGGAAGG
GTTGTTAGGGGAGATTGAGTCGGTCCCCGGTATCCGCAAGGCGTATACGGTCAATCTTTGA

Upstream 100 bases:

>100_bases
TCCTAACTGCGTCCTCATGCCCCCGCTACTATTCAGCAGCAGGGGCTCTTTATTGGGGGTGTAAAATCAGAGGGCCAAAT
TCAGTTTCAACGGAGATCCC

Downstream 100 bases:

>100_bases
ACACCACTTTTCGGTGTAGGATGCGCGGACAAGCGTAGGATCTGACTACTTGAACGTCCGCATCGTCCTGGTTGCAACGC
AGGGGGCACGGAACCTGGGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MPKVLVSDAIDQAGIEILTQVAQVTYEPDLSPATLLETIPQYDALMIRSGTKVTALVIEAAQRLRIIGRAGVGVDNVDLQ
AATRKGIVVVNSPEGNTIAAAEHAIALMMSLSRHVGEANASLKAGQWKRSQFIGVEVYKKTIGVVGLGRIGSHVTRVARA
LGMQIVAFDPYISAERAQQLGARLVDLEQLFHEADYITLHVPRTPETTHLINEKTLASMKPTARIINCARGGLIDEQALY
VALKEGRIAGAALDVFENEPLGESPLCALGREVILTPHLGASTEEAQTNVAIDVAEQIRDVLLGLPARTAVNIPGLRAEV
LQELKPYLELADTLGNLVGQLAGGRVDALDIRLQGILAAKDAQPIVVAALKGLLTPALRERVNFVNALLEAKERGIRVTE
TRDSAFADYAGSIRLEARGPEGERSVTGALLAEDELRITNIDEFPISVAPSRYMLITLHRDMPGIIGKVGSFLGSYNVNI
AGMQVGRKLVRGDAVMMVSLDDPLPEGLLGEIESVPGIRKAYTVNL

Sequences:

>Translated_526_residues
MPKVLVSDAIDQAGIEILTQVAQVTYEPDLSPATLLETIPQYDALMIRSGTKVTALVIEAAQRLRIIGRAGVGVDNVDLQ
AATRKGIVVVNSPEGNTIAAAEHAIALMMSLSRHVGEANASLKAGQWKRSQFIGVEVYKKTIGVVGLGRIGSHVTRVARA
LGMQIVAFDPYISAERAQQLGARLVDLEQLFHEADYITLHVPRTPETTHLINEKTLASMKPTARIINCARGGLIDEQALY
VALKEGRIAGAALDVFENEPLGESPLCALGREVILTPHLGASTEEAQTNVAIDVAEQIRDVLLGLPARTAVNIPGLRAEV
LQELKPYLELADTLGNLVGQLAGGRVDALDIRLQGILAAKDAQPIVVAALKGLLTPALRERVNFVNALLEAKERGIRVTE
TRDSAFADYAGSIRLEARGPEGERSVTGALLAEDELRITNIDEFPISVAPSRYMLITLHRDMPGIIGKVGSFLGSYNVNI
AGMQVGRKLVRGDAVMMVSLDDPLPEGLLGEIESVPGIRKAYTVNL
>Mature_525_residues
PKVLVSDAIDQAGIEILTQVAQVTYEPDLSPATLLETIPQYDALMIRSGTKVTALVIEAAQRLRIIGRAGVGVDNVDLQA
ATRKGIVVVNSPEGNTIAAAEHAIALMMSLSRHVGEANASLKAGQWKRSQFIGVEVYKKTIGVVGLGRIGSHVTRVARAL
GMQIVAFDPYISAERAQQLGARLVDLEQLFHEADYITLHVPRTPETTHLINEKTLASMKPTARIINCARGGLIDEQALYV
ALKEGRIAGAALDVFENEPLGESPLCALGREVILTPHLGASTEEAQTNVAIDVAEQIRDVLLGLPARTAVNIPGLRAEVL
QELKPYLELADTLGNLVGQLAGGRVDALDIRLQGILAAKDAQPIVVAALKGLLTPALRERVNFVNALLEAKERGIRVTET
RDSAFADYAGSIRLEARGPEGERSVTGALLAEDELRITNIDEFPISVAPSRYMLITLHRDMPGIIGKVGSFLGSYNVNIA
GMQVGRKLVRGDAVMMVSLDDPLPEGLLGEIESVPGIRKAYTVNL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=405, Percent_Identity=41.9753086419753, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI61743967, Length=300, Percent_Identity=35, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4557497, Length=302, Percent_Identity=34.7682119205298, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=34.6428571428571, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=34.6428571428571, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=35.408560311284, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=33.0708661417323, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=35.0769230769231, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=33.5403726708075, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=42.8571428571429, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1788660, Length=258, Percent_Identity=31.3953488372093, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=284, Percent_Identity=26.056338028169, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=46.583850931677, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=31.25, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=37.0030581039755, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=35.474006116208, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=30.5785123966942, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=323, Percent_Identity=25.077399380805, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=28, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=151, Percent_Identity=32.4503311258278, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=45, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24646446, Length=329, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646448, Length=329, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646452, Length=329, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646450, Length=329, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI62472511, Length=286, Percent_Identity=35.3146853146853, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=32.475884244373, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=30.0632911392405, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=27.7070063694268, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=27.7070063694268, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=27.7070063694268, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=27.7070063694268, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585516, Length=277, Percent_Identity=29.9638989169675, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56392; Mature: 56261

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVSDAIDQAGIEILTQVAQVTYEPDLSPATLLETIPQYDALMIRSGTKVTALVIEA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHH
AQRLRIIGRAGVGVDNVDLQAATRKGIVVVNSPEGNTIAAAEHAIALMMSLSRHVGEANA
HHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCC
SLKAGQWKRSQFIGVEVYKKTIGVVGLGRIGSHVTRVARALGMQIVAFDPYISAERAQQL
CCCCCCCCCHHEEHHHHHHHHHCEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GARLVDLEQLFHEADYITLHVPRTPETTHLINEKTLASMKPTARIINCARGGLIDEQALY
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHCCCHHHHHHHHCCCCCCCCEEE
VALKEGRIAGAALDVFENEPLGESPLCALGREVILTPHLGASTEEAQTNVAIDVAEQIRD
EEEECCCEEHHHHHHHCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHCCCEEHHHHHHHH
VLLGLPARTAVNIPGLRAEVLQELKPYLELADTLGNLVGQLAGGRVDALDIRLQGILAAK
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEC
DAQPIVVAALKGLLTPALRERVNFVNALLEAKERGIRVTETRDSAFADYAGSIRLEARGP
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCEEEEECCC
EGERSVTGALLAEDELRITNIDEFPISVAPSRYMLITLHRDMPGIIGKVGSFLGSYNVNI
CCCCHHCEEEEECCCEEEECCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCEE
AGMQVGRKLVRGDAVMMVSLDDPLPEGLLGEIESVPGIRKAYTVNL
EHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure 
PKVLVSDAIDQAGIEILTQVAQVTYEPDLSPATLLETIPQYDALMIRSGTKVTALVIEA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHH
AQRLRIIGRAGVGVDNVDLQAATRKGIVVVNSPEGNTIAAAEHAIALMMSLSRHVGEANA
HHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCC
SLKAGQWKRSQFIGVEVYKKTIGVVGLGRIGSHVTRVARALGMQIVAFDPYISAERAQQL
CCCCCCCCCHHEEHHHHHHHHHCEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GARLVDLEQLFHEADYITLHVPRTPETTHLINEKTLASMKPTARIINCARGGLIDEQALY
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHCCCHHHHHHHHCCCCCCCCEEE
VALKEGRIAGAALDVFENEPLGESPLCALGREVILTPHLGASTEEAQTNVAIDVAEQIRD
EEEECCCEEHHHHHHHCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHCCCEEHHHHHHHH
VLLGLPARTAVNIPGLRAEVLQELKPYLELADTLGNLVGQLAGGRVDALDIRLQGILAAK
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEC
DAQPIVVAALKGLLTPALRERVNFVNALLEAKERGIRVTETRDSAFADYAGSIRLEARGP
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCEEEEECCC
EGERSVTGALLAEDELRITNIDEFPISVAPSRYMLITLHRDMPGIIGKVGSFLGSYNVNI
CCCCHHCEEEEECCCEEEECCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCEE
AGMQVGRKLVRGDAVMMVSLDDPLPEGLLGEIESVPGIRKAYTVNL
EHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]