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The map label for this gene is algA [H]

Identifier: 37521707

GI number: 37521707

Start: 2289132

End: 2289539

Strand: Direct

Name: algA [H]

Synonym: glr2138

Alternate gene names: 37521707

Gene position: 2289132-2289539 (Clockwise)

Preceding gene: 37521705

Following gene: 37521708

Centisome position: 49.13

GC content: 61.76

Gene sequence:

>408_bases
GTGAGGAACGCCATGGAAACTTCGCAAATGCTGAGTCCGGACATCGATATCGTCGCTTCCACCGTACTCCGGCCCTGGGG
TTCGTTCACGGTCCTGGGCGAAGGCAACGGCTACAAAGTCAAGCGCATCGAGGTCAAACCCGGCCACCGCCTGAGCCTGC
AGATGCACCACCACCGCTCCGAGCACTGGGTCGTCGTCTCCGGCACCGCCCGCGTCGTCTGCAACGACCGCATCGAACTC
ATCCACGCCAACCAGTCGACCTACGTGCCCCCCTGCGCCACCCACCGCCTCGAAAACCCCGGCATCATCCCGCTGGTGAT
TATCGAAGTTCAAAACGGTCAGTACCTCGGCGAGGACGACATCATCCGCTTCGAGGACGACTACAAGCGTATCGAGCCGC
GCTCTTGA

Upstream 100 bases:

>100_bases
AGGATACAGATTTTCATGCCACAGCCTGACAACACAGGGGAGTACCCTGTTATTCTGTTCCAGGTAAAGGTGCAGCGTCA
CCGTCCGAGCGTCCAAAAGG

Downstream 100 bases:

>100_bases
TCCCGAAAATCTTGTTAAAGAAGTCTACCGGCGGCTGAGCTTGCCCTACAGTGTTGGGCAAGATACCTCCTAACTGCGTC
CTCATGCCCCCGCTACTATT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MRNAMETSQMLSPDIDIVASTVLRPWGSFTVLGEGNGYKVKRIEVKPGHRLSLQMHHHRSEHWVVVSGTARVVCNDRIEL
IHANQSTYVPPCATHRLENPGIIPLVIIEVQNGQYLGEDDIIRFEDDYKRIEPRS

Sequences:

>Translated_135_residues
MRNAMETSQMLSPDIDIVASTVLRPWGSFTVLGEGNGYKVKRIEVKPGHRLSLQMHHHRSEHWVVVSGTARVVCNDRIEL
IHANQSTYVPPCATHRLENPGIIPLVIIEVQNGQYLGEDDIIRFEDDYKRIEPRS
>Mature_135_residues
MRNAMETSQMLSPDIDIVASTVLRPWGSFTVLGEGNGYKVKRIEVKPGHRLSLQMHHHRSEHWVVVSGTARVVCNDRIEL
IHANQSTYVPPCATHRLENPGIIPLVIIEVQNGQYLGEDDIIRFEDDYKRIEPRS

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0662

COG function: function code G; Mannose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=110, Percent_Identity=58.1818181818182, Blast_Score=140, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 15383; Mature: 15383

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNAMETSQMLSPDIDIVASTVLRPWGSFTVLGEGNGYKVKRIEVKPGHRLSLQMHHHRS
CCCCCCHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECCCC
EHWVVVSGTARVVCNDRIELIHANQSTYVPPCATHRLENPGIIPLVIIEVQNGQYLGEDD
CCEEEEECCEEEEECCCEEEEECCCCCCCCCHHHCCCCCCCEEEEEEEEECCCCEECCCC
IIRFEDDYKRIEPRS
EEEECCCCCCCCCCC
>Mature Secondary Structure
MRNAMETSQMLSPDIDIVASTVLRPWGSFTVLGEGNGYKVKRIEVKPGHRLSLQMHHHRS
CCCCCCHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECCCC
EHWVVVSGTARVVCNDRIELIHANQSTYVPPCATHRLENPGIIPLVIIEVQNGQYLGEDD
CCEEEEECCEEEEECCCEEEEECCCCCCCCCHHHCCCCCCCEEEEEEEEECCCCEECCCC
IIRFEDDYKRIEPRS
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]