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The map label for this gene is lpxA [H]

Identifier: 37521436

GI number: 37521436

Start: 1988452

End: 1989309

Strand: Direct

Name: lpxA [H]

Synonym: glr1867

Alternate gene names: 37521436

Gene position: 1988452-1989309 (Clockwise)

Preceding gene: 37521435

Following gene: 37521437

Centisome position: 42.68

GC content: 67.83

Gene sequence:

>858_bases
ATGAATCCACCCGCCTTGACGACACCTTTGATCCACCCCTCGGCCGTCATTCACCCGCGGGCTGTCCTGCACGAGAGCGT
CCAGGTCGGCCCGTTTGCGGTGGTGGGTGAGCACGTGCGCATCGGGGCGGGCACGGTGGTCGGTCCCCACGCCGTGATCG
ACGGCTGGACGGAGATTGGCTGCGACAACGTCATCTATAACGGCGCCAGCATCGGCACCCCGCCCCAGGATCTCAAGTAC
CGCAACGAACCCTCGCGGGTGCGCATCGGCGACAACAACGACATCCGCGAATTTGTCACCGTCAACCGCGGCACCGACAA
GGGCAGCGAGACCGTCGTGGGCGACAAGAATCTGTTGATGGCCTACGTGCACGTCGGCCACAACTGCGCCATCGGCGACA
ATGTCGTGATCACCAACGCCGTGATGCTCGCCGGGCATGTGCACATCGAGTCGCAGGCGCGCATCGGCGGCCTGGTGGGC
GTCCACCAGTTCGTGCACATCGGCAGGCTCGCCTACATCGGCGGCATGGCCCGCGTCGACCGCGACGTGCCGCCTTTTAC
GCTGGTGGAGGGCCACCCGGGCCGCACCCGCGGCCTCAACTGGGTGGGTCTCGAGCGCGCCGGCATCTCCGACGCCGCCG
GGGCCGACCGCGAGAGCTACCGGCTGTTGCGCCAGGCCTACAAGTTGCTCTACCGCTCCGCCACGCCCCTCGAAAAAGCC
CTGGTCGAGTTGCAGGCCCTGGCGGGCAATCCCTATATCGATCACCTGCACACGTTTTTGAGCCGGTCGGTGGGCGACCC
GGCGCGACGCGGTCCCACCCCCGCCGCCCGCAAGCGCCCCGGCGGCGACGACGCCTAA

Upstream 100 bases:

>100_bases
TCGGAGGTCGATGGCAAACTGGTAGCCGAAGCCGAGATTATGTTTTCCCTGGTAGATTGAGTCCAGCCATCTCCCGCCCA
TGCCACAATCGTCAAAAGTC

Downstream 100 bases:

>100_bases
ATCGATGGCAGCCCGGCTTTTTGTCAGTACCGGCGAGGTCTCAGGCGACCTGCACGGCAGCTATCTTATCCAGGCGCTGC
GCGAGCGCCGTCCGGATCTG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNPPALTTPLIHPSAVIHPRAVLHESVQVGPFAVVGEHVRIGAGTVVGPHAVIDGWTEIGCDNVIYNGASIGTPPQDLKY
RNEPSRVRIGDNNDIREFVTVNRGTDKGSETVVGDKNLLMAYVHVGHNCAIGDNVVITNAVMLAGHVHIESQARIGGLVG
VHQFVHIGRLAYIGGMARVDRDVPPFTLVEGHPGRTRGLNWVGLERAGISDAAGADRESYRLLRQAYKLLYRSATPLEKA
LVELQALAGNPYIDHLHTFLSRSVGDPARRGPTPAARKRPGGDDA

Sequences:

>Translated_285_residues
MNPPALTTPLIHPSAVIHPRAVLHESVQVGPFAVVGEHVRIGAGTVVGPHAVIDGWTEIGCDNVIYNGASIGTPPQDLKY
RNEPSRVRIGDNNDIREFVTVNRGTDKGSETVVGDKNLLMAYVHVGHNCAIGDNVVITNAVMLAGHVHIESQARIGGLVG
VHQFVHIGRLAYIGGMARVDRDVPPFTLVEGHPGRTRGLNWVGLERAGISDAAGADRESYRLLRQAYKLLYRSATPLEKA
LVELQALAGNPYIDHLHTFLSRSVGDPARRGPTPAARKRPGGDDA
>Mature_285_residues
MNPPALTTPLIHPSAVIHPRAVLHESVQVGPFAVVGEHVRIGAGTVVGPHAVIDGWTEIGCDNVIYNGASIGTPPQDLKY
RNEPSRVRIGDNNDIREFVTVNRGTDKGSETVVGDKNLLMAYVHVGHNCAIGDNVVITNAVMLAGHVHIESQARIGGLVG
VHQFVHIGRLAYIGGMARVDRDVPPFTLVEGHPGRTRGLNWVGLERAGISDAAGADRESYRLLRQAYKLLYRSATPLEKA
LVELQALAGNPYIDHLHTFLSRSVGDPARRGPTPAARKRPGGDDA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=43.4108527131783, Blast_Score=208, Evalue=4e-55,
Organism=Escherichia coli, GI1786376, Length=198, Percent_Identity=29.2929292929293, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30594; Mature: 30594

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPALTTPLIHPSAVIHPRAVLHESVQVGPFAVVGEHVRIGAGTVVGPHAVIDGWTEIG
CCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCEEEECCEEEECCCCEECCHHHHCCHHHHC
CDNVIYNGASIGTPPQDLKYRNEPSRVRIGDNNDIREFVTVNRGTDKGSETVVGDKNLLM
CCCEEECCCCCCCCHHHCCCCCCCCEEEECCCCCCCHHEEEECCCCCCCCEEECCCCEEE
AYVHVGHNCAIGDNVVITNAVMLAGHVHIESQARIGGLVGVHQFVHIGRLAYIGGMARVD
EEEEECCCCCCCCCEEEEEHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHC
RDVPPFTLVEGHPGRTRGLNWVGLERAGISDAAGADRESYRLLRQAYKLLYRSATPLEKA
CCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
LVELQALAGNPYIDHLHTFLSRSVGDPARRGPTPAARKRPGGDDA
HHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MNPPALTTPLIHPSAVIHPRAVLHESVQVGPFAVVGEHVRIGAGTVVGPHAVIDGWTEIG
CCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCEEEECCEEEECCCCEECCHHHHCCHHHHC
CDNVIYNGASIGTPPQDLKYRNEPSRVRIGDNNDIREFVTVNRGTDKGSETVVGDKNLLM
CCCEEECCCCCCCCHHHCCCCCCCCEEEECCCCCCCHHEEEECCCCCCCCEEECCCCEEE
AYVHVGHNCAIGDNVVITNAVMLAGHVHIESQARIGGLVGVHQFVHIGRLAYIGGMARVD
EEEEECCCCCCCCCEEEEEHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHC
RDVPPFTLVEGHPGRTRGLNWVGLERAGISDAAGADRESYRLLRQAYKLLYRSATPLEKA
CCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHH
LVELQALAGNPYIDHLHTFLSRSVGDPARRGPTPAARKRPGGDDA
HHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]