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The map label for this gene is lpxB [H]

Identifier: 37521437

GI number: 37521437

Start: 1989314

End: 1990477

Strand: Direct

Name: lpxB [H]

Synonym: glr1868

Alternate gene names: 37521437

Gene position: 1989314-1990477 (Clockwise)

Preceding gene: 37521436

Following gene: 37521440

Centisome position: 42.7

GC content: 62.71

Gene sequence:

>1164_bases
ATGGCAGCCCGGCTTTTTGTCAGTACCGGCGAGGTCTCAGGCGACCTGCACGGCAGCTATCTTATCCAGGCGCTGCGCGA
GCGCCGTCCGGATCTGGAGATCCAGGCATTAGGCGGCCGGCGCATGGCGCAGTTGGGCATCCCGATGCTGAGCGACACCA
CCACCCTCTCCTCGATCGGCGTCGTCGAGGCCATTCCTTATATCCTGCCGACCCTGCGCATCCAGGCGCGCCTCAAAAAG
CTGCTCACCAGCTTTCGCCCCGACGCGGTGGTGCTCATCGACTACATCGGCTCCAACGTCGGGGTGGGCAAGCTGGCCCA
GAAGCTTGGTATCCCGGTGATCTACTACATTGCCCCCCAGGAATGGGTCTGGCGGACTTTTAAGGGAGACACCGCCCAGA
TCGTCGGTTTTACCGACCTCATCCTCGCCATCTTTCCGGAGGAAGCCCGCTTCTACACCCGCCACGGCGGCAACGTCCGC
TGGATCGGCCATCCGCTGGTCGACATCGTCCGCACCACCGTGGGTCGTGCTGAATTTCGCGCGCGCATGGACACCCCAGC
GGAGGCGCCGGTGGTAGTACTCACTCCGGCCTCACGCACCCAGGAATTGCGCCATTTGATGCCGCTCTTGTTCGAGACGG
CCCGCGCCATCGCCGGGCAGTTGCCGGAGGTACGCTTCTGGCTTTCGGTCTCCACCCCGACCTTCCAGGAGGCCATCGAA
CGGGGCGCCAAAGCGGCGGGAATCGCCGTGCAGTTCATCCCCCCCGGCAGCAATTACGACGCGCTCGCCGCCGCCGACTT
GTTGCTCACCAAATCCGGCACGATCAATTTGGAAGCAGCACTGTTGAACTTGCCCCAGGTGGTGGCCTACCGCGTCGATC
CGCGCACCTACTGGTTCGCCAAAAAGATCATGGGCTTTACGATTCCCTACATGTGCCCGGTCAACCTGGTGGAGATGAGT
GCCGTGGTGCCCGAATTTTTGCAGGACGAAGCTACGGTCGAGACCCTCTCTGCCGCAAGTTTGGAATTGCTCAAGGACCC
CAAAGCTGCCCAGCGCATGCGTGAGGGGTACGCGCGGGTCAAAGCCCAATTGGGTGAACCGGGCGTCATCGCCAGAGGGG
CGGAAGCTATCCTCAAGGTGCTCAACGGCACCGGTCTGTCCTGA

Upstream 100 bases:

>100_bases
CACCTGCACACGTTTTTGAGCCGGTCGGTGGGCGACCCGGCGCGACGCGGTCCCACCCCCGCCGCCCGCAAGCGCCCCGG
CGGCGACGACGCCTAAATCG

Downstream 100 bases:

>100_bases
CCGCTTAAACCAGTGTCAAAAAGCCCAGCACGGCGACTCCGAGGTGAATAGCGACAAACGCCGCCCGGCCCAAAAAGCGG
CCCCCCGGCAAACGCTTGCC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MAARLFVSTGEVSGDLHGSYLIQALRERRPDLEIQALGGRRMAQLGIPMLSDTTTLSSIGVVEAIPYILPTLRIQARLKK
LLTSFRPDAVVLIDYIGSNVGVGKLAQKLGIPVIYYIAPQEWVWRTFKGDTAQIVGFTDLILAIFPEEARFYTRHGGNVR
WIGHPLVDIVRTTVGRAEFRARMDTPAEAPVVVLTPASRTQELRHLMPLLFETARAIAGQLPEVRFWLSVSTPTFQEAIE
RGAKAAGIAVQFIPPGSNYDALAAADLLLTKSGTINLEAALLNLPQVVAYRVDPRTYWFAKKIMGFTIPYMCPVNLVEMS
AVVPEFLQDEATVETLSAASLELLKDPKAAQRMREGYARVKAQLGEPGVIARGAEAILKVLNGTGLS

Sequences:

>Translated_387_residues
MAARLFVSTGEVSGDLHGSYLIQALRERRPDLEIQALGGRRMAQLGIPMLSDTTTLSSIGVVEAIPYILPTLRIQARLKK
LLTSFRPDAVVLIDYIGSNVGVGKLAQKLGIPVIYYIAPQEWVWRTFKGDTAQIVGFTDLILAIFPEEARFYTRHGGNVR
WIGHPLVDIVRTTVGRAEFRARMDTPAEAPVVVLTPASRTQELRHLMPLLFETARAIAGQLPEVRFWLSVSTPTFQEAIE
RGAKAAGIAVQFIPPGSNYDALAAADLLLTKSGTINLEAALLNLPQVVAYRVDPRTYWFAKKIMGFTIPYMCPVNLVEMS
AVVPEFLQDEATVETLSAASLELLKDPKAAQRMREGYARVKAQLGEPGVIARGAEAILKVLNGTGLS
>Mature_386_residues
AARLFVSTGEVSGDLHGSYLIQALRERRPDLEIQALGGRRMAQLGIPMLSDTTTLSSIGVVEAIPYILPTLRIQARLKKL
LTSFRPDAVVLIDYIGSNVGVGKLAQKLGIPVIYYIAPQEWVWRTFKGDTAQIVGFTDLILAIFPEEARFYTRHGGNVRW
IGHPLVDIVRTTVGRAEFRARMDTPAEAPVVVLTPASRTQELRHLMPLLFETARAIAGQLPEVRFWLSVSTPTFQEAIER
GAKAAGIAVQFIPPGSNYDALAAADLLLTKSGTINLEAALLNLPQVVAYRVDPRTYWFAKKIMGFTIPYMCPVNLVEMSA
VVPEFLQDEATVETLSAASLELLKDPKAAQRMREGYARVKAQLGEPGVIARGAEAILKVLNGTGLS

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=373, Percent_Identity=30.2949061662198, Blast_Score=155, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42377; Mature: 42246

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARLFVSTGEVSGDLHGSYLIQALRERRPDLEIQALGGRRMAQLGIPMLSDTTTLSSIG
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCCCHHHHCC
VVEAIPYILPTLRIQARLKKLLTSFRPDAVVLIDYIGSNVGVGKLAQKLGIPVIYYIAPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCC
EWVWRTFKGDTAQIVGFTDLILAIFPEEARFYTRHGGNVRWIGHPLVDIVRTTVGRAEFR
HHHHEECCCCCEEEEEHHHHHHHHCCCHHHEEECCCCCEEECCCHHHHHHHHHHHHHHHH
ARMDTPAEAPVVVLTPASRTQELRHLMPLLFETARAIAGQLPEVRFWLSVSTPTFQEAIE
HHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHH
RGAKAAGIAVQFIPPGSNYDALAAADLLLTKSGTINLEAALLNLPQVVAYRVDPRTYWFA
CCCCCCCEEEEEECCCCCCCHHHHHHHHEECCCCEEEHHHHHCCCHHEEEEECCCHHHHH
KKIMGFTIPYMCPVNLVEMSAVVPEFLQDEATVETLSAASLELLKDPKAAQRMREGYARV
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KAQLGEPGVIARGAEAILKVLNGTGLS
HHHCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AARLFVSTGEVSGDLHGSYLIQALRERRPDLEIQALGGRRMAQLGIPMLSDTTTLSSIG
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCCCCHHHHCC
VVEAIPYILPTLRIQARLKKLLTSFRPDAVVLIDYIGSNVGVGKLAQKLGIPVIYYIAPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCC
EWVWRTFKGDTAQIVGFTDLILAIFPEEARFYTRHGGNVRWIGHPLVDIVRTTVGRAEFR
HHHHEECCCCCEEEEEHHHHHHHHCCCHHHEEECCCCCEEECCCHHHHHHHHHHHHHHHH
ARMDTPAEAPVVVLTPASRTQELRHLMPLLFETARAIAGQLPEVRFWLSVSTPTFQEAIE
HHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHH
RGAKAAGIAVQFIPPGSNYDALAAADLLLTKSGTINLEAALLNLPQVVAYRVDPRTYWFA
CCCCCCCEEEEEECCCCCCCHHHHHHHHEECCCCEEEHHHHHCCCHHEEEEECCCHHHHH
KKIMGFTIPYMCPVNLVEMSAVVPEFLQDEATVETLSAASLELLKDPKAAQRMREGYARV
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KAQLGEPGVIARGAEAILKVLNGTGLS
HHHCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]