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The map label for this gene is pleC [H]

Identifier: 37521062

GI number: 37521062

Start: 1605576

End: 1607384

Strand: Reverse

Name: pleC [H]

Synonym: gll1493

Alternate gene names: 37521062

Gene position: 1607384-1605576 (Counterclockwise)

Preceding gene: 37521063

Following gene: 37521059

Centisome position: 34.5

GC content: 65.84

Gene sequence:

>1809_bases
ATGACAGAGATCAGCAACTCCCTGCGGGCGGAAAAGGACATGCAAGCGGCCCGCAAGCGCATTGCCCAACTCGAAGAAAC
CTGCAGACAGCTCCAATCGGACCTGGCCAGGACCAACGGCAAAGCGTCCGTCCAGGTGACCGGCGTCCTCGAAGAAAGCT
GGCGTTCGCTGGTCCAGTACGTGCCGGATACGATCGCCGCCGTCGATCGACGGGGATGTATCTTGTTTGCCAATCGCGCC
CTGTCCGGTCTTTGTCTTGAGCGGATGATCGGACAGAATCTGGGCGATTACTTGCTGCCGGAGCATGCCGAGCGGATGGG
CGAGGTTTTTGCCCGGGTCACAGCCACCGGCGAGGCCGAAAGCTGTGAGGTGGCCGCACCCGATGACCACGGCCGGGTGT
TCTGGTACCGGGCCAGCGTCGGGCCGGTAGCCCACCAAGGGCAACTCACCTCGTTGATCGCCGTCTTCAGCGACATCACC
GAGCGCAAGCGCTCCGAGGAAGCGTTCGCCGCCCTGTTGCAGCGCGAGCAGGGACTGCACCGGGCCATCGAGCACAGCGA
GCGCCGCCACCGCTTTTTGGCGCGGGCGAGTGTGGTGCTGTCCAGTTCCCTCGATGCGGAGACCACCTTTGCCGACCTTG
CGCGGCTGGTGGTTCCCCAGGTGGCCGATGGGTTCGCCGTCGATCTGGTCGAGCCGGACGGGGCGTTGCGCTGTCTGGTC
CTTGCCCGCGCCGATGCCGAGAAGGTGGGCTGGGCGCGTCGGCTGCGCGAACGCGAGCCGAGCGATCCGGCCGCGGCCTG
GGGCAGCGCCCAGGTAATTCGCACCGGTTGTCCGCAACTGTACTCTGCATTCTCCGAGGCACTGCTGTCCGCCTGCGCCG
GCAGCCCGGAACACCTGGAGCTGCTGCGCGGGGGAAGCTATCGCTCGGCGATGGTGGTGCCGCTGGTGGCGCGCGGCCAG
ACCCTGGGGACGCTCACCTTTGTGCTCGCGGAGTCCGACCGCCGCTACGGTCCGTCGGACCTGTCGCTGGCGGAGGATCT
GGCCGGGCGCGCCGCCCTCGCCTTCGACAACGCCCGGCTCTACGCGGCTGAGCAGCGCGAGCGCAACCGGGCGGAGGTGG
CCAATCGCGCCAAGGACGAATTTCTGGCGACGGTCTCCCACGAATTGCGCACCCCGCTCAATTCGATTTTGGGCTTTACG
CAGTTGCTCAGGCGCCATGCGGGCGACCCTGAGCGGCTGGCCGTCGCCCTCGATGCCATCGAGCGCAACGCCAAGGCCCA
GGCCCGCCTCACCGAAGATTTGCTCGATGTGTCGCGGATCATCACCGGCAAATTAAAGCTCACCATCCAGCCGGTACGGG
TAAACGCCCTGGTCGATGCGGCCATCGAGACGATGCGCACCGCCGCCGAGGCCAAAAATATTGCCCTGAGCGCAATCTAT
CCGGAGGCTCCCTGCACCCTCCAGGCCGATTCCAACCGGTTGCAGCAGGTGATCTGGAATTTGCTTTCCAACGCCATCAA
ATTCACCCCCGTCGGCGGCCGGATTCGGGTGAGTGTCGAGCGTCGAGCCGGGCAGGTGCACATCGCGGTCGCCGACTCCG
GCATGGGCATTGCGGCAGAGTTTTTGCCCTTCGTATTCGACCGCTTTCGCCAGGCCGACAGCTCCAGTACCCGCACCTTC
GGCGGTCTGGGGCTGGGGCTCGCCATCGTCCGCCATCTGGTCGAATTGCACGGCGGCAGTGTCGAAGCCCACAGCGCCGG
ACCCAACCAGGGGGCGACTTTTGTGGTGTCGCTGCCGCTAGCACCTTAA

Upstream 100 bases:

>100_bases
CGGGCTTTTGCCGGTAAGATAGAATGCAGCTGATTGTGGTTTTGGTATTGCCTGCGCAGACACCGGTGTTGCCCTGGATC
CCCCGTTTTCGGAATCGCCA

Downstream 100 bases:

>100_bases
AAAACGCGGCTAGCCGGATTTGGACTGGAGCAGTTTGATCGCTTCTTCGAATTCTTCGATGGGCAAAGCGCCCTTGAGTA
CGATGCCGTTGAGCACAAAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MTEISNSLRAEKDMQAARKRIAQLEETCRQLQSDLARTNGKASVQVTGVLEESWRSLVQYVPDTIAAVDRRGCILFANRA
LSGLCLERMIGQNLGDYLLPEHAERMGEVFARVTATGEAESCEVAAPDDHGRVFWYRASVGPVAHQGQLTSLIAVFSDIT
ERKRSEEAFAALLQREQGLHRAIEHSERRHRFLARASVVLSSSLDAETTFADLARLVVPQVADGFAVDLVEPDGALRCLV
LARADAEKVGWARRLREREPSDPAAAWGSAQVIRTGCPQLYSAFSEALLSACAGSPEHLELLRGGSYRSAMVVPLVARGQ
TLGTLTFVLAESDRRYGPSDLSLAEDLAGRAALAFDNARLYAAEQRERNRAEVANRAKDEFLATVSHELRTPLNSILGFT
QLLRRHAGDPERLAVALDAIERNAKAQARLTEDLLDVSRIITGKLKLTIQPVRVNALVDAAIETMRTAAEAKNIALSAIY
PEAPCTLQADSNRLQQVIWNLLSNAIKFTPVGGRIRVSVERRAGQVHIAVADSGMGIAAEFLPFVFDRFRQADSSSTRTF
GGLGLGLAIVRHLVELHGGSVEAHSAGPNQGATFVVSLPLAP

Sequences:

>Translated_602_residues
MTEISNSLRAEKDMQAARKRIAQLEETCRQLQSDLARTNGKASVQVTGVLEESWRSLVQYVPDTIAAVDRRGCILFANRA
LSGLCLERMIGQNLGDYLLPEHAERMGEVFARVTATGEAESCEVAAPDDHGRVFWYRASVGPVAHQGQLTSLIAVFSDIT
ERKRSEEAFAALLQREQGLHRAIEHSERRHRFLARASVVLSSSLDAETTFADLARLVVPQVADGFAVDLVEPDGALRCLV
LARADAEKVGWARRLREREPSDPAAAWGSAQVIRTGCPQLYSAFSEALLSACAGSPEHLELLRGGSYRSAMVVPLVARGQ
TLGTLTFVLAESDRRYGPSDLSLAEDLAGRAALAFDNARLYAAEQRERNRAEVANRAKDEFLATVSHELRTPLNSILGFT
QLLRRHAGDPERLAVALDAIERNAKAQARLTEDLLDVSRIITGKLKLTIQPVRVNALVDAAIETMRTAAEAKNIALSAIY
PEAPCTLQADSNRLQQVIWNLLSNAIKFTPVGGRIRVSVERRAGQVHIAVADSGMGIAAEFLPFVFDRFRQADSSSTRTF
GGLGLGLAIVRHLVELHGGSVEAHSAGPNQGATFVVSLPLAP
>Mature_601_residues
TEISNSLRAEKDMQAARKRIAQLEETCRQLQSDLARTNGKASVQVTGVLEESWRSLVQYVPDTIAAVDRRGCILFANRAL
SGLCLERMIGQNLGDYLLPEHAERMGEVFARVTATGEAESCEVAAPDDHGRVFWYRASVGPVAHQGQLTSLIAVFSDITE
RKRSEEAFAALLQREQGLHRAIEHSERRHRFLARASVVLSSSLDAETTFADLARLVVPQVADGFAVDLVEPDGALRCLVL
ARADAEKVGWARRLREREPSDPAAAWGSAQVIRTGCPQLYSAFSEALLSACAGSPEHLELLRGGSYRSAMVVPLVARGQT
LGTLTFVLAESDRRYGPSDLSLAEDLAGRAALAFDNARLYAAEQRERNRAEVANRAKDEFLATVSHELRTPLNSILGFTQ
LLRRHAGDPERLAVALDAIERNAKAQARLTEDLLDVSRIITGKLKLTIQPVRVNALVDAAIETMRTAAEAKNIALSAIYP
EAPCTLQADSNRLQQVIWNLLSNAIKFTPVGGRIRVSVERRAGQVHIAVADSGMGIAAEFLPFVFDRFRQADSSSTRTFG
GLGLGLAIVRHLVELHGGSVEAHSAGPNQGATFVVSLPLAP

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=39.5061728395062, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=36.7965367965368, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=34.5381526104418, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=33.4728033472803, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=38.0753138075314, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=31.1538461538462, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786912, Length=315, Percent_Identity=27.9365079365079, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=32.1266968325792, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=31.7180616740088, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=30.8035714285714, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=28.695652173913, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=29.3333333333333, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=32.843137254902, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.6315789473684, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=243, Percent_Identity=27.5720164609054, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1789808, Length=205, Percent_Identity=30.2439024390244, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=26.3392857142857, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=146, Percent_Identity=34.9315068493151, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65458; Mature: 65327

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEISNSLRAEKDMQAARKRIAQLEETCRQLQSDLARTNGKASVQVTGVLEESWRSLVQY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHH
VPDTIAAVDRRGCILFANRALSGLCLERMIGQNLGDYLLPEHAERMGEVFARVTATGEAE
CCHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
SCEVAAPDDHGRVFWYRASVGPVAHQGQLTSLIAVFSDITERKRSEEAFAALLQREQGLH
CCEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAIEHSERRHRFLARASVVLSSSLDAETTFADLARLVVPQVADGFAVDLVEPDGALRCLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
LARADAEKVGWARRLREREPSDPAAAWGSAQVIRTGCPQLYSAFSEALLSACAGSPEHLE
EECCCHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LLRGGSYRSAMVVPLVARGQTLGTLTFVLAESDRRYGPSDLSLAEDLAGRAALAFDNARL
HHCCCCCCCEEEEEHHHCCCCHHHEEEEEECCCCCCCCCCHHHHHHHCCCEEEEECCCCE
YAAEQRERNRAEVANRAKDEFLATVSHELRTPLNSILGFTQLLRRHAGDPERLAVALDAI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERNAKAQARLTEDLLDVSRIITGKLKLTIQPVRVNALVDAAIETMRTAAEAKNIALSAIY
HCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEC
PEAPCTLQADSNRLQQVIWNLLSNAIKFTPVGGRIRVSVERRAGQVHIAVADSGMGIAAE
CCCCEEEECCHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCEEEEEEECCCCCHHHH
FLPFVFDRFRQADSSSTRTFGGLGLGLAIVRHLVELHGGSVEAHSAGPNQGATFVVSLPL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECC
AP
CC
>Mature Secondary Structure 
TEISNSLRAEKDMQAARKRIAQLEETCRQLQSDLARTNGKASVQVTGVLEESWRSLVQY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHH
VPDTIAAVDRRGCILFANRALSGLCLERMIGQNLGDYLLPEHAERMGEVFARVTATGEAE
CCHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
SCEVAAPDDHGRVFWYRASVGPVAHQGQLTSLIAVFSDITERKRSEEAFAALLQREQGLH
CCEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAIEHSERRHRFLARASVVLSSSLDAETTFADLARLVVPQVADGFAVDLVEPDGALRCLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
LARADAEKVGWARRLREREPSDPAAAWGSAQVIRTGCPQLYSAFSEALLSACAGSPEHLE
EECCCHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LLRGGSYRSAMVVPLVARGQTLGTLTFVLAESDRRYGPSDLSLAEDLAGRAALAFDNARL
HHCCCCCCCEEEEEHHHCCCCHHHEEEEEECCCCCCCCCCHHHHHHHCCCEEEEECCCCE
YAAEQRERNRAEVANRAKDEFLATVSHELRTPLNSILGFTQLLRRHAGDPERLAVALDAI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERNAKAQARLTEDLLDVSRIITGKLKLTIQPVRVNALVDAAIETMRTAAEAKNIALSAIY
HCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEC
PEAPCTLQADSNRLQQVIWNLLSNAIKFTPVGGRIRVSVERRAGQVHIAVADSGMGIAAE
CCCCEEEECCHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCEEEEEEECCCCCHHHH
FLPFVFDRFRQADSSSTRTFGGLGLGLAIVRHLVELHGGSVEAHSAGPNQGATFVVSLPL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]