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The map label for this gene is tetA [H]

Identifier: 37521059

GI number: 37521059

Start: 1601297

End: 1602487

Strand: Reverse

Name: tetA [H]

Synonym: gll1490

Alternate gene names: 37521059

Gene position: 1602487-1601297 (Counterclockwise)

Preceding gene: 37521062

Following gene: 37521058

Centisome position: 34.4

GC content: 64.74

Gene sequence:

>1191_bases
GTGCCCAAGCCATCACCTTTGTTGTTCGTGCTGTTGACGGTCTTTATCGATCTGGCCGGGGGCAGCTTGCTGGTGCCGGT
GCTGCCCTATCTGGTGGAGCGCTTCCGATCCGACGCCCTCACCATCGGTCTGCTCTCCTCGGTGTTCTCGGTGGCCCAGT
TTCTGGCCACCCCGGTTCTGGGCAGTCTCTCCGACCGCTTCGGACGACGGCCGGTGCTGATTGCCTGCGTGTTCGGCACC
GCGGTCAGTTATTTTCTGTTTGCCCTGGCGGGCAATTTGTGGCTGATGTTTGTGGCGCGGATCATTGCGGGAGCCACCGG
CGGGGTGATCGCCACCGCCCAGGCCTATATCGCCGATGTCACTCCCCCCGAGAAGCGCACCCAGGCGTTCGGCCTGATCG
GGGCGGCCTTTGGTCTCGGGTTCATCCTGGGACCGGCCCTGGGAGGAGCGTTGCTGACCATCGATCTCAACGCACCGGTT
TACTGCGCTGGGTTCCTGGCTCTGGCCAATACGGTATTGGGATATTTCACTTTGGCCGAATCGCTGCCGCCTGAGCGGCG
CCGGGCCGTGGGCTGGCAGGAACTCAATCCGCTCGGGCAACTGGTGCGGCTGGCGCTCGACACCAAGATCCGCGGTTTGC
TGGCCGGTTTTTTTACCTTCAACGCGGTCTTTGCCGGTTTTACGAGCATCTTTGCGCTGTCGATCCGCGATCGCTTCGGC
TGGGGACCGCAACTGGTGGTCTGGCTGTTCGTCTTCATCGGGGTGATCGCCACCGTCGTCCAGGGCGGGCTTATCCGCAA
GCTGGTGCCGCGCTTCGGCGAAGCGCGCCTGGCGCTGTGGGGGTTGGCGCTGGTGGCGTTGGCCTTTGGGCTGGTGGCGG
CCATTCCCTCGGGAGACTGGCTCTACCTCACCCAGGCGGTGCTGGCTCTGGGGGTGGGGCTGGCCACCCCGTCGCTGCGC
GGACTGATTTCCAACAGTGTCGCCGACAACGAGCAGGGCCGCGTGCTGGGGGGCAGCCAATCGCTGGTGAGCCTGGCGCA
GGTGATCGGCCCCCTGGCTGCGAGTGTCTGCTACGACTACCTGGGGCGGCTGGTGCCCTTCTGGGGCGGCGCGCTGGTGA
TGCTCGCGGCGGTGGGTTTTGTCTATGCCAACTTGCGGCGACAGCAATCCGCTCCATCGCCTTTCAAGTAA

Upstream 100 bases:

>100_bases
CCTGGGGCGCGCCTGCACCGCTTCGGGGAAGCGGGATCGCTTCTGTGGCCCGCACCGCCAGGGCGTACTATCGACACGTG
GCCTCTCTAGCCGTGCGCGC

Downstream 100 bases:

>100_bases
ATATTCATTTTTGGTCTAGCAATTCCTTTGTATATTTTACTCGAATGTTACTATGTCCTAAAGTTAACCTTATACTTTAA
CGGCAGCCATTTTGGTTGGA

Product: tetracycline resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MPKPSPLLFVLLTVFIDLAGGSLLVPVLPYLVERFRSDALTIGLLSSVFSVAQFLATPVLGSLSDRFGRRPVLIACVFGT
AVSYFLFALAGNLWLMFVARIIAGATGGVIATAQAYIADVTPPEKRTQAFGLIGAAFGLGFILGPALGGALLTIDLNAPV
YCAGFLALANTVLGYFTLAESLPPERRRAVGWQELNPLGQLVRLALDTKIRGLLAGFFTFNAVFAGFTSIFALSIRDRFG
WGPQLVVWLFVFIGVIATVVQGGLIRKLVPRFGEARLALWGLALVALAFGLVAAIPSGDWLYLTQAVLALGVGLATPSLR
GLISNSVADNEQGRVLGGSQSLVSLAQVIGPLAASVCYDYLGRLVPFWGGALVMLAAVGFVYANLRRQQSAPSPFK

Sequences:

>Translated_396_residues
MPKPSPLLFVLLTVFIDLAGGSLLVPVLPYLVERFRSDALTIGLLSSVFSVAQFLATPVLGSLSDRFGRRPVLIACVFGT
AVSYFLFALAGNLWLMFVARIIAGATGGVIATAQAYIADVTPPEKRTQAFGLIGAAFGLGFILGPALGGALLTIDLNAPV
YCAGFLALANTVLGYFTLAESLPPERRRAVGWQELNPLGQLVRLALDTKIRGLLAGFFTFNAVFAGFTSIFALSIRDRFG
WGPQLVVWLFVFIGVIATVVQGGLIRKLVPRFGEARLALWGLALVALAFGLVAAIPSGDWLYLTQAVLALGVGLATPSLR
GLISNSVADNEQGRVLGGSQSLVSLAQVIGPLAASVCYDYLGRLVPFWGGALVMLAAVGFVYANLRRQQSAPSPFK
>Mature_395_residues
PKPSPLLFVLLTVFIDLAGGSLLVPVLPYLVERFRSDALTIGLLSSVFSVAQFLATPVLGSLSDRFGRRPVLIACVFGTA
VSYFLFALAGNLWLMFVARIIAGATGGVIATAQAYIADVTPPEKRTQAFGLIGAAFGLGFILGPALGGALLTIDLNAPVY
CAGFLALANTVLGYFTLAESLPPERRRAVGWQELNPLGQLVRLALDTKIRGLLAGFFTFNAVFAGFTSIFALSIRDRFGW
GPQLVVWLFVFIGVIATVVQGGLIRKLVPRFGEARLALWGLALVALAFGLVAAIPSGDWLYLTQAVLALGVGLATPSLRG
LISNSVADNEQGRVLGGSQSLVSLAQVIGPLAASVCYDYLGRLVPFWGGALVMLAAVGFVYANLRRQQSAPSPFK

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=347, Percent_Identity=29.3948126801153, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI225703102, Length=347, Percent_Identity=29.3948126801153, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI39753965, Length=349, Percent_Identity=25.5014326647564, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI94721311, Length=349, Percent_Identity=25.214899713467, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI217416366, Length=431, Percent_Identity=23.4338747099768, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI166064062, Length=366, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI166064060, Length=366, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787291, Length=401, Percent_Identity=25.6857855361596, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=348, Percent_Identity=29.5977011494253, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71996331, Length=357, Percent_Identity=27.1708683473389, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985371, Length=349, Percent_Identity=24.9283667621776, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17738085, Length=356, Percent_Identity=30.6179775280899, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357569, Length=349, Percent_Identity=27.2206303724928, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656463, Length=357, Percent_Identity=27.1708683473389, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656468, Length=357, Percent_Identity=27.1708683473389, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161080926, Length=357, Percent_Identity=27.1708683473389, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161080924, Length=357, Percent_Identity=27.1708683473389, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221513297, Length=222, Percent_Identity=29.7297297297297, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667557, Length=215, Percent_Identity=26.5116279069767, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667561, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41863; Mature: 41732

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PKPSPLLFVLLTVFIDLAGGSLLVPVLPYLVERFRSDALTIGLLSSVFSVAQFLATPVL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GSLSDRFGRRPVLIACVFGTAVSYFLFALAGNLWLMFVARIIAGATGGVIATAQAYIADV
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
TPPEKRTQAFGLIGAAFGLGFILGPALGGALLTIDLNAPVYCAGFLALANTVLGYFTLAE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
SLPPERRRAVGWQELNPLGQLVRLALDTKIRGLLAGFFTFNAVFAGFTSIFALSIRDRFG
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGPQLVVWLFVFIGVIATVVQGGLIRKLVPRFGEARLALWGLALVALAFGLVAAIPSGDW
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCH
LYLTQAVLALGVGLATPSLRGLISNSVADNEQGRVLGGSQSLVSLAQVIGPLAASVCYDY
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
LGRLVPFWGGALVMLAAVGFVYANLRRQQSAPSPFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]