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The map label for this gene is purE [H]

Identifier: 37520820

GI number: 37520820

Start: 1329345

End: 1329860

Strand: Reverse

Name: purE [H]

Synonym: gvip176

Alternate gene names: 37520820

Gene position: 1329860-1329345 (Counterclockwise)

Preceding gene: 37520821

Following gene: 37520819

Centisome position: 28.54

GC content: 66.86

Gene sequence:

>516_bases
ATGACCCATCCTGCGCTGGTGGGGATCATCATGGGCAGCGATTCGGATCTGCCCACGATGAAGGCGGCGGCCGAGGTCTG
CACCGAATTCGAGGTGCCCTGTTCGGTGGCGATCGTCTCGGCCCACCGCACGCCGGAGCGCATGTTTGAATTTGCGGCGA
CCGCCCACTCCCGGGGCTTGAAGGTGATCGTGGCCGGGGCGGGCGGGGCGGCCCACCTGCCGGGGATGGTGGCGGCCCTC
ACACCCCTGCCGGTGATTGGAGTGCCGGTACCGGTCACCGCCCTGGGGGGCGTCGATGCGCTCTATTCGATTGTCCAGAT
GCCCGCAGGCATTCCGGTGGCCACCGTGGCGATCGGCAACGCCCGCAACGCCGGTCTGCTCGCTGTGCAGATCCTGGCGA
CGGCGGACCCGGTGTTGCAGCAAAAAATCGTCGCTTATCGCGAGCGGCTGCGCACGGCGGTCGAGAAAAAACAGGCCCGC
CTCGAAGAGCTGGGTTGGCGGAACTACGAGCCTTAA

Upstream 100 bases:

>100_bases
GCCCGCGACCCGGCGGTGGCCTACGAGCGTGCCCTCGCCGCCCGCGAGGCGCTGGGGATATGAGGTGCCGTGCGTTAGGC
GTTGGGACTAGGGGCAATCA

Downstream 100 bases:

>100_bases
AATCGGCCCGGAGAACCGTGACGTCTTGGTTTGGGGCGTGTAGATCTAAAAAAGTTTCGGATGGTAGCCGTGAGCGACGA
AGACTGGATGGAGCGCTGCC

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTHPALVGIIMGSDSDLPTMKAAAEVCTEFEVPCSVAIVSAHRTPERMFEFAATAHSRGLKVIVAGAGGAAHLPGMVAAL
TPLPVIGVPVPVTALGGVDALYSIVQMPAGIPVATVAIGNARNAGLLAVQILATADPVLQQKIVAYRERLRTAVEKKQAR
LEELGWRNYEP

Sequences:

>Translated_171_residues
MTHPALVGIIMGSDSDLPTMKAAAEVCTEFEVPCSVAIVSAHRTPERMFEFAATAHSRGLKVIVAGAGGAAHLPGMVAAL
TPLPVIGVPVPVTALGGVDALYSIVQMPAGIPVATVAIGNARNAGLLAVQILATADPVLQQKIVAYRERLRTAVEKKQAR
LEELGWRNYEP
>Mature_170_residues
THPALVGIIMGSDSDLPTMKAAAEVCTEFEVPCSVAIVSAHRTPERMFEFAATAHSRGLKVIVAGAGGAAHLPGMVAALT
PLPVIGVPVPVTALGGVDALYSIVQMPAGIPVATVAIGNARNAGLLAVQILATADPVLQQKIVAYRERLRTAVEKKQARL
EELGWRNYEP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=152, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI119220557, Length=152, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5453539, Length=152, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1786734, Length=115, Percent_Identity=60.8695652173913, Blast_Score=141, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=59.1463414634146, Blast_Score=187, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17855; Mature: 17724

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPALVGIIMGSDSDLPTMKAAAEVCTEFEVPCSVAIVSAHRTPERMFEFAATAHSRGL
CCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
KVIVAGAGGAAHLPGMVAALTPLPVIGVPVPVTALGGVDALYSIVQMPAGIPVATVAIGN
EEEEECCCCCHHHCHHHHHHCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECC
ARNAGLLAVQILATADPVLQQKIVAYRERLRTAVEKKQARLEELGWRNYEP
CCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
THPALVGIIMGSDSDLPTMKAAAEVCTEFEVPCSVAIVSAHRTPERMFEFAATAHSRGL
CCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
KVIVAGAGGAAHLPGMVAALTPLPVIGVPVPVTALGGVDALYSIVQMPAGIPVATVAIGN
EEEEECCCCCHHHCHHHHHHCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECC
ARNAGLLAVQILATADPVLQQKIVAYRERLRTAVEKKQARLEELGWRNYEP
CCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]