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The map label for this gene is purK [H]

Identifier: 37520821

GI number: 37520821

Start: 1329898

End: 1331043

Strand: Reverse

Name: purK [H]

Synonym: gvip177

Alternate gene names: 37520821

Gene position: 1331043-1329898 (Counterclockwise)

Preceding gene: 37520823

Following gene: 37520820

Centisome position: 28.57

GC content: 70.77

Gene sequence:

>1146_bases
GTGCGACCGGCAGCAGGGCGGACGGGCCTGCCGACGGTCGGTATTGTCGGGGGCGGCCAGCTTGGCCGGATGATGGCCCT
GGCGGGCCATGCCCTGGGATTGCGGCTGGTGGTGCTCGACCCCGATCCGGCCAGCCCCGCCTCCCAGGTGGTGCCCGTCT
CACTGGAGGGGGCGTTCGACGACATCGAGAGCCTGCGCTCCCTGGCCAGGATCACCGACATCGTCACGTTCGAAAACGAG
TGGGTGGAGCCGCTGCTGGTCGCCCAGCTGGAGGCGGATGGCTGCCGGGTCTGGCCCGCCAGCCGGACCCTCGCGCGCAT
CCAGGACAAGTTGCACCAGCGCACCCATCTGGCTGCGGCCGGATTGCCGGTGCCGCGCTTCGCCGCCGCCCCGAGTCTGG
AGGCGGTGCGGGCGTGGGGAGGAAGCCGGCCGCTGGTGCTCAAGACCCGCCTTCAGGGCTACGACGGTCACGGCGTGCGC
ATCGTCGAGAACCCCGCGCACCTGGAGGACGCCTGGGAGGCCCTCGCAGGTCAACCGCTTATGGTCGAAGCGTTCGTGAC
TTTTGAACGGGAACTGGCGGTGATGGTGGCCCGCTCCTCAACCGGCGAGGTGCGCTCCTATCCGGTGGTCGAGACGCGCC
AGCGTCGGCACGTCTGCCACACTGTGATCGCCCCGGCTCCAGTGGACGAAGTGATCCGCGAGCGCGCCGGAGCGGTTGCC
CGCGCCGCCGTCGAGGCGGTCGAGGGAGTGGGCATCTTCGGTGTCGAGCTGTTTGTGGACGCCCGCGGGGAGGTGAGCAT
CAATGAACTGGCCCCCCGCCCCCACAACTCCGGCCATTACACCCTCGACGCCTGCACCACCAGCCAGTTCGAGCAGCACC
TGCGCGCCGTGCTCGGTTGGCCGCTGGCGGACCCATCCATGCACAGTCCGGCGGCGGTGATGGTGAACATTCTGGCCGAA
GGCGACGCGCCTGAGGCCGAACCCGATCTGGCGGCGGCCCTCGCCTTCGCTGGGGTCAAAGTGCATTGGTACGGCAAGCG
CGGCGCCCGGCCCGGCCGCAAGCTCGGCCACATCACCGCCGTCGCCCGCGACCCGGCGGTGGCCTACGAGCGTGCCCTCG
CCGCCCGCGAGGCGCTGGGGATATGA

Upstream 100 bases:

>100_bases
TGTCCGCCACCGCCAGGGTCTGTGTCCGATTGCGATTAAGATAAAGATCTTTGATCTGCGCAACGTGATGATGGGAAGTG
GGGCACTGGAAGCGGAGCTT

Downstream 100 bases:

>100_bases
GGTGCCGTGCGTTAGGCGTTGGGACTAGGGGCAATCAATGACCCATCCTGCGCTGGTGGGGATCATCATGGGCAGCGATT
CGGATCTGCCCACGATGAAG

Product: phosphoribosylaminoimidazole carboxylase ATPase-subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRPAAGRTGLPTVGIVGGGQLGRMMALAGHALGLRLVVLDPDPASPASQVVPVSLEGAFDDIESLRSLARITDIVTFENE
WVEPLLVAQLEADGCRVWPASRTLARIQDKLHQRTHLAAAGLPVPRFAAAPSLEAVRAWGGSRPLVLKTRLQGYDGHGVR
IVENPAHLEDAWEALAGQPLMVEAFVTFERELAVMVARSSTGEVRSYPVVETRQRRHVCHTVIAPAPVDEVIRERAGAVA
RAAVEAVEGVGIFGVELFVDARGEVSINELAPRPHNSGHYTLDACTTSQFEQHLRAVLGWPLADPSMHSPAAVMVNILAE
GDAPEAEPDLAAALAFAGVKVHWYGKRGARPGRKLGHITAVARDPAVAYERALAAREALGI

Sequences:

>Translated_381_residues
MRPAAGRTGLPTVGIVGGGQLGRMMALAGHALGLRLVVLDPDPASPASQVVPVSLEGAFDDIESLRSLARITDIVTFENE
WVEPLLVAQLEADGCRVWPASRTLARIQDKLHQRTHLAAAGLPVPRFAAAPSLEAVRAWGGSRPLVLKTRLQGYDGHGVR
IVENPAHLEDAWEALAGQPLMVEAFVTFERELAVMVARSSTGEVRSYPVVETRQRRHVCHTVIAPAPVDEVIRERAGAVA
RAAVEAVEGVGIFGVELFVDARGEVSINELAPRPHNSGHYTLDACTTSQFEQHLRAVLGWPLADPSMHSPAAVMVNILAE
GDAPEAEPDLAAALAFAGVKVHWYGKRGARPGRKLGHITAVARDPAVAYERALAAREALGI
>Mature_381_residues
MRPAAGRTGLPTVGIVGGGQLGRMMALAGHALGLRLVVLDPDPASPASQVVPVSLEGAFDDIESLRSLARITDIVTFENE
WVEPLLVAQLEADGCRVWPASRTLARIQDKLHQRTHLAAAGLPVPRFAAAPSLEAVRAWGGSRPLVLKTRLQGYDGHGVR
IVENPAHLEDAWEALAGQPLMVEAFVTFERELAVMVARSSTGEVRSYPVVETRQRRHVCHTVIAPAPVDEVIRERAGAVA
RAAVEAVEGVGIFGVELFVDARGEVSINELAPRPHNSGHYTLDACTTSQFEQHLRAVLGWPLADPSMHSPAAVMVNILAE
GDAPEAEPDLAAALAFAGVKVHWYGKRGARPGRKLGHITAVARDPAVAYERALAAREALGI

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=373, Percent_Identity=31.0991957104558, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788155, Length=387, Percent_Identity=30.749354005168, Blast_Score=114, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=375, Percent_Identity=39.7333333333333, Blast_Score=258, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40695; Mature: 40695

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAAGRTGLPTVGIVGGGQLGRMMALAGHALGLRLVVLDPDPASPASQVVPVSLEGAFD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCHH
DIESLRSLARITDIVTFENEWVEPLLVAQLEADGCRVWPASRTLARIQDKLHQRTHLAAA
HHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHC
GLPVPRFAAAPSLEAVRAWGGSRPLVLKTRLQGYDGHGVRIVENPAHLEDAWEALAGQPL
CCCCCCHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCE
MVEAFVTFERELAVMVARSSTGEVRSYPVVETRQRRHVCHTVIAPAPVDEVIRERAGAVA
EEEHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RAAVEAVEGVGIFGVELFVDARGEVSINELAPRPHNSGHYTLDACTTSQFEQHLRAVLGW
HHHHHHHHCCCEEEEEEEEECCCCEEHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHCC
PLADPSMHSPAAVMVNILAEGDAPEAEPDLAAALAFAGVKVHWYGKRGARPGRKLGHITA
CCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCHHHEEEE
VARDPAVAYERALAAREALGI
ECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRPAAGRTGLPTVGIVGGGQLGRMMALAGHALGLRLVVLDPDPASPASQVVPVSLEGAFD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCHH
DIESLRSLARITDIVTFENEWVEPLLVAQLEADGCRVWPASRTLARIQDKLHQRTHLAAA
HHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHC
GLPVPRFAAAPSLEAVRAWGGSRPLVLKTRLQGYDGHGVRIVENPAHLEDAWEALAGQPL
CCCCCCHHCCCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCE
MVEAFVTFERELAVMVARSSTGEVRSYPVVETRQRRHVCHTVIAPAPVDEVIRERAGAVA
EEEHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RAAVEAVEGVGIFGVELFVDARGEVSINELAPRPHNSGHYTLDACTTSQFEQHLRAVLGW
HHHHHHHHCCCEEEEEEEEECCCCEEHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHCC
PLADPSMHSPAAVMVNILAEGDAPEAEPDLAAALAFAGVKVHWYGKRGARPGRKLGHITA
CCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCHHHEEEE
VARDPAVAYERALAAREALGI
ECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA