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The map label for this gene is phoP [H]

Identifier: 37520429

GI number: 37520429

Start: 906514

End: 907230

Strand: Direct

Name: phoP [H]

Synonym: glr0860

Alternate gene names: 37520429

Gene position: 906514-907230 (Clockwise)

Preceding gene: 37520428

Following gene: 37520430

Centisome position: 19.46

GC content: 68.06

Gene sequence:

>717_bases
GTGCCGCCGTCTCCGGGTGTAACCATGCCGAACGCCGCTATCCTCGTCGTCGAAGACGACCCGCTCATTCTTGAGACCAT
TCGCCGCTACCTCGAACACGCAGGGCACCGTTGCCATTGCGCCGCCGACGGTTGGGAGGCCGACCGGCTCGCCCTGCGCC
ACCGCCCGGATCTGGTGGTGCTCGACTGGATGCTGCCGGGCGTGGACGGTCTGGCGCTGTGCGAGCGCTGGCGCAAAGGG
GAGTACTTCGCGCCTGTGTTGATGCTCACGGCGCGCACCGAGGAGGACCACCGCGTGCGCGCTCTGGCGGGCGGGGCAGA
CGACTACCTGGACAAACCTTTCTCTGCAAAGGAACTGGTGGCCCGGGTGCAGGCCCTGCTGCGCCGCGCCTACGCCAGCG
GTTACCGCGACTGCAGCCCCAAAAACGGCCTGCTGGTCGATCGCAACACCCGTCAGGTGCAGCTGCACGGTCGCCCGATC
GACCTGCGGGCCCGGGAATTCGACCTGCTCGCCCAGTTGGCCGATCACCCCGGCCGGGTGTACTCGCGCGACGAACTGCT
CGAGCGGGTCTGGGGCTACGACTTCGAAGGCGGTCACCGGACGATCGACGTGCACGTGCGCAAGCTCCGCGAGAAGCTCG
AGCCGGATCCCACCCGCCCGGTCTATGTGCTCACCGTCTGGGGTGTGGGTTACAAATTCGCGGGACCGCCGCGGTGA

Upstream 100 bases:

>100_bases
CAGTCTGTCGGCACCTGCCGCGGCTGGGCGTTTTCCCGTGTTTAACAGATTTCTAACATTCTTTCGGTAGCCTGGGTCTC
AAGGCAGAGCCTCCCCGCCT

Downstream 100 bases:

>100_bases
GCTTCCACCCAAGGGCCCTGGTGCCCCGCACGCTCTGGGGCCGCCTGACCCTCGCCTTCGTGGGCCTGACGGCCGCCTGC
CTGTGGGGAATCGGCCTGGT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MPPSPGVTMPNAAILVVEDDPLILETIRRYLEHAGHRCHCAADGWEADRLALRHRPDLVVLDWMLPGVDGLALCERWRKG
EYFAPVLMLTARTEEDHRVRALAGGADDYLDKPFSAKELVARVQALLRRAYASGYRDCSPKNGLLVDRNTRQVQLHGRPI
DLRAREFDLLAQLADHPGRVYSRDELLERVWGYDFEGGHRTIDVHVRKLREKLEPDPTRPVYVLTVWGVGYKFAGPPR

Sequences:

>Translated_238_residues
MPPSPGVTMPNAAILVVEDDPLILETIRRYLEHAGHRCHCAADGWEADRLALRHRPDLVVLDWMLPGVDGLALCERWRKG
EYFAPVLMLTARTEEDHRVRALAGGADDYLDKPFSAKELVARVQALLRRAYASGYRDCSPKNGLLVDRNTRQVQLHGRPI
DLRAREFDLLAQLADHPGRVYSRDELLERVWGYDFEGGHRTIDVHVRKLREKLEPDPTRPVYVLTVWGVGYKFAGPPR
>Mature_237_residues
PPSPGVTMPNAAILVVEDDPLILETIRRYLEHAGHRCHCAADGWEADRLALRHRPDLVVLDWMLPGVDGLALCERWRKGE
YFAPVLMLTARTEEDHRVRALAGGADDYLDKPFSAKELVARVQALLRRAYASGYRDCSPKNGLLVDRNTRQVQLHGRPID
LRAREFDLLAQLADHPGRVYSRDELLERVWGYDFEGGHRTIDVHVRKLREKLEPDPTRPVYVLTVWGVGYKFAGPPR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=38.2608695652174, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=42.6008968609865, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=36.7713004484305, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=38.1165919282511, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=36.8888888888889, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=36.7713004484305, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=37.8378378378378, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.6515837104072, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=32.3404255319149, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=35.5855855855856, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=34.2105263157895, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=32.0675105485232, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=35.1111111111111, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790299, Length=154, Percent_Identity=33.1168831168831, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=36.9747899159664, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27118; Mature: 26987

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSPGVTMPNAAILVVEDDPLILETIRRYLEHAGHRCHCAADGWEADRLALRHRPDLVV
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEE
LDWMLPGVDGLALCERWRKGEYFAPVLMLTARTEEDHRVRALAGGADDYLDKPFSAKELV
EEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCHHHHCCCCCHHHHH
ARVQALLRRAYASGYRDCSPKNGLLVDRNTRQVQLHGRPIDLRAREFDLLAQLADHPGRV
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YSRDELLERVWGYDFEGGHRTIDVHVRKLREKLEPDPTRPVYVLTVWGVGYKFAGPPR
CCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCC
>Mature Secondary Structure 
PPSPGVTMPNAAILVVEDDPLILETIRRYLEHAGHRCHCAADGWEADRLALRHRPDLVV
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEE
LDWMLPGVDGLALCERWRKGEYFAPVLMLTARTEEDHRVRALAGGADDYLDKPFSAKELV
EEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCHHHHCCCCCHHHHH
ARVQALLRRAYASGYRDCSPKNGLLVDRNTRQVQLHGRPIDLRAREFDLLAQLADHPGRV
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YSRDELLERVWGYDFEGGHRTIDVHVRKLREKLEPDPTRPVYVLTVWGVGYKFAGPPR
CCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]