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The map label for this gene is mtrB [H]

Identifier: 37520430

GI number: 37520430

Start: 907227

End: 908669

Strand: Direct

Name: mtrB [H]

Synonym: glr0861

Alternate gene names: 37520430

Gene position: 907227-908669 (Clockwise)

Preceding gene: 37520429

Following gene: 37520436

Centisome position: 19.47

GC content: 70.27

Gene sequence:

>1443_bases
GTGAGCTTCCACCCAAGGGCCCTGGTGCCCCGCACGCTCTGGGGCCGCCTGACCCTCGCCTTCGTGGGCCTGACGGCCGC
CTGCCTGTGGGGAATCGGCCTGGTGCTCGGCGACGCCCTCAACAATTTTTTTGTTCAAGACGCCCAGGCGCGCCTCGACC
GCCAGGCTCGCGGGCTCGCGGAGTTGGCGCCCTCCGATTGGCGGGCGGCGACTCGCCTGAGCGCCCGTCAAAATCAACTG
CAGGTGCTCGTCTTCGACGCGCGGGAGAACACGGTGGCGAGCGCCCAGGGGCTCGCCGGGGTGCACCAGGTGGTGATCCC
CCGCGGCATCGTCCGCAAGACCCTCACAGGCCAGGGCCAGCGGGGCCGCCTCTGGGTCGAGGGGGAGACCAAGTATCCCT
GGTGGCTCTACAGCACCGCACCCGTGCGCACCAGCGGCGCGATCGGCGCGGCGGTCTACGTGGCGATGCCCCTGCTGCGG
CCCCGCCGTTTTGCCCAGCAGGTGACCGGTCTTGCGATGCTGTGCGTGGGCGGGGCGATGGTGCTGGCGGTACTGGCCGG
TTTGGGCCTCGCCCGCACGATCGCGGGTCCTTTGCAGCGGTTGACCCGGCAGGCCAGACAGCTGGAAGCGGGGGACTACC
AGGCCCGCTGCGGCCTGGACGGGGACGATGAAATCGCCCGCCTGGGCTTGACGCTCGACGCGATGGCCGGACGACTGGAG
GAGACGATCGCGAGCCTCAAAGCCCAGGAAGCTTCCCGCCGGGAGTTGCTGGCCAACATTTCCCACGATCTGCGCACGCC
GTTGACGGCAATGCGCCTCAGCTTAGAGGCGGTGCTCGACGGGGTCGTCAACGGCGAGCAGGTGGGCGGCTACCTGGAGA
AGATGCGGCGCGAAGCGATTTACCTCGGGCAACTGGTTGATCAATTGATGCTGTTGGCCCGCTCCGACAGCGGCCAACTC
GAAGTCAGCCTGCGGGAGGTCCCGATCGCCGCACTGCTCGGCGAAGCGCTCGAGCGGATCGAGCCGCAGGCCATCGCCCG
GGGCGTCTTCCTGGATGGGCGCTGGTCCGGGCACCTGCCGGCCGTCAGGTTGGACGCGCATCTGAGCGCCCAGGTGCTCG
CCAACCTGCTCGACAACGCCGTCAAGTACACCCCTGAAGGCGGTTCGGTGATCCTCTCGGCGCGCGACACCGGCGGCGGG
GCGGTGCAGATCACCGTCGAAGACACCGGATCCGGCATGGACGCGCAGGTGCTCAAACGGGCGACCGAACGCTTCTGGCG
GGCGGATCCGGCTCGCTCGGGAGGCGGGTTCGGCCTGGGGCTCGCCATCGCCGAGCGCCTGTGCCGCCTGCAGGGGGTCG
GCCTCGAAATCGCCAGCGCCCCGGGCCGGGGAACGGCGGTGATCCTGCGCCTGCCCGTGCGGCGCCCCGACTCGGCGGCG
TAG

Upstream 100 bases:

>100_bases
ACGTGCGCAAGCTCCGCGAGAAGCTCGAGCCGGATCCCACCCGCCCGGTCTATGTGCTCACCGTCTGGGGTGTGGGTTAC
AAATTCGCGGGACCGCCGCG

Downstream 100 bases:

>100_bases
CCGGAGCACAACTTAGGGCAGACCGGGCGGGGGCAACTGCACCTGCACCGGTTTGGCCGCCTCGCCGCCTTCGCTCGGCA
CGATCACCAGGTAGCGGCGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSFHPRALVPRTLWGRLTLAFVGLTAACLWGIGLVLGDALNNFFVQDAQARLDRQARGLAELAPSDWRAATRLSARQNQL
QVLVFDARENTVASAQGLAGVHQVVIPRGIVRKTLTGQGQRGRLWVEGETKYPWWLYSTAPVRTSGAIGAAVYVAMPLLR
PRRFAQQVTGLAMLCVGGAMVLAVLAGLGLARTIAGPLQRLTRQARQLEAGDYQARCGLDGDDEIARLGLTLDAMAGRLE
ETIASLKAQEASRRELLANISHDLRTPLTAMRLSLEAVLDGVVNGEQVGGYLEKMRREAIYLGQLVDQLMLLARSDSGQL
EVSLREVPIAALLGEALERIEPQAIARGVFLDGRWSGHLPAVRLDAHLSAQVLANLLDNAVKYTPEGGSVILSARDTGGG
AVQITVEDTGSGMDAQVLKRATERFWRADPARSGGGFGLGLAIAERLCRLQGVGLEIASAPGRGTAVILRLPVRRPDSAA

Sequences:

>Translated_480_residues
MSFHPRALVPRTLWGRLTLAFVGLTAACLWGIGLVLGDALNNFFVQDAQARLDRQARGLAELAPSDWRAATRLSARQNQL
QVLVFDARENTVASAQGLAGVHQVVIPRGIVRKTLTGQGQRGRLWVEGETKYPWWLYSTAPVRTSGAIGAAVYVAMPLLR
PRRFAQQVTGLAMLCVGGAMVLAVLAGLGLARTIAGPLQRLTRQARQLEAGDYQARCGLDGDDEIARLGLTLDAMAGRLE
ETIASLKAQEASRRELLANISHDLRTPLTAMRLSLEAVLDGVVNGEQVGGYLEKMRREAIYLGQLVDQLMLLARSDSGQL
EVSLREVPIAALLGEALERIEPQAIARGVFLDGRWSGHLPAVRLDAHLSAQVLANLLDNAVKYTPEGGSVILSARDTGGG
AVQITVEDTGSGMDAQVLKRATERFWRADPARSGGGFGLGLAIAERLCRLQGVGLEIASAPGRGTAVILRLPVRRPDSAA
>Mature_479_residues
SFHPRALVPRTLWGRLTLAFVGLTAACLWGIGLVLGDALNNFFVQDAQARLDRQARGLAELAPSDWRAATRLSARQNQLQ
VLVFDARENTVASAQGLAGVHQVVIPRGIVRKTLTGQGQRGRLWVEGETKYPWWLYSTAPVRTSGAIGAAVYVAMPLLRP
RRFAQQVTGLAMLCVGGAMVLAVLAGLGLARTIAGPLQRLTRQARQLEAGDYQARCGLDGDDEIARLGLTLDAMAGRLEE
TIASLKAQEASRRELLANISHDLRTPLTAMRLSLEAVLDGVVNGEQVGGYLEKMRREAIYLGQLVDQLMLLARSDSGQLE
VSLREVPIAALLGEALERIEPQAIARGVFLDGRWSGHLPAVRLDAHLSAQVLANLLDNAVKYTPEGGSVILSARDTGGGA
VQITVEDTGSGMDAQVLKRATERFWRADPARSGGGFGLGLAIAERLCRLQGVGLEIASAPGRGTAVILRLPVRRPDSAA

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=346, Percent_Identity=32.6589595375723, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786783, Length=353, Percent_Identity=25.2124645892351, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=31.9502074688797, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=250, Percent_Identity=30.8, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789149, Length=362, Percent_Identity=25.9668508287293, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=28.2700421940928, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=26.8181818181818, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790861, Length=274, Percent_Identity=29.9270072992701, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=29.8755186721992, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=224, Percent_Identity=29.4642857142857, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=26.3636363636364, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=27.1493212669683, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=287, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=29.3388429752066, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=298, Percent_Identity=21.1409395973154, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=313, Percent_Identity=27.7955271565495, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=229, Percent_Identity=27.0742358078603, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51468; Mature: 51337

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFHPRALVPRTLWGRLTLAFVGLTAACLWGIGLVLGDALNNFFVQDAQARLDRQARGLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELAPSDWRAATRLSARQNQLQVLVFDARENTVASAQGLAGVHQVVIPRGIVRKTLTGQGQ
HCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
RGRLWVEGETKYPWWLYSTAPVRTSGAIGAAVYVAMPLLRPRRFAQQVTGLAMLCVGGAM
CCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
VLAVLAGLGLARTIAGPLQRLTRQARQLEAGDYQARCGLDGDDEIARLGLTLDAMAGRLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHCCHHHHHHHHHH
ETIASLKAQEASRRELLANISHDLRTPLTAMRLSLEAVLDGVVNGEQVGGYLEKMRREAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLGQLVDQLMLLARSDSGQLEVSLREVPIAALLGEALERIEPQAIARGVFLDGRWSGHLP
HHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHCCHHHHHCCEEECCCCCCCCC
AVRLDAHLSAQVLANLLDNAVKYTPEGGSVILSARDTGGGAVQITVEDTGSGMDAQVLKR
EEEECHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
ATERFWRADPARSGGGFGLGLAIAERLCRLQGVGLEIASAPGRGTAVILRLPVRRPDSAA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SFHPRALVPRTLWGRLTLAFVGLTAACLWGIGLVLGDALNNFFVQDAQARLDRQARGLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELAPSDWRAATRLSARQNQLQVLVFDARENTVASAQGLAGVHQVVIPRGIVRKTLTGQGQ
HCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
RGRLWVEGETKYPWWLYSTAPVRTSGAIGAAVYVAMPLLRPRRFAQQVTGLAMLCVGGAM
CCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
VLAVLAGLGLARTIAGPLQRLTRQARQLEAGDYQARCGLDGDDEIARLGLTLDAMAGRLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHCCHHHHHHHHHH
ETIASLKAQEASRRELLANISHDLRTPLTAMRLSLEAVLDGVVNGEQVGGYLEKMRREAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLGQLVDQLMLLARSDSGQLEVSLREVPIAALLGEALERIEPQAIARGVFLDGRWSGHLP
HHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHCCHHHHHCCEEECCCCCCCCC
AVRLDAHLSAQVLANLLDNAVKYTPEGGSVILSARDTGGGAVQITVEDTGSGMDAQVLKR
EEEECHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
ATERFWRADPARSGGGFGLGLAIAERLCRLQGVGLEIASAPGRGTAVILRLPVRRPDSAA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA