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The map label for this gene is gmd [H]

Identifier: 37520332

GI number: 37520332

Start: 816198

End: 817247

Strand: Reverse

Name: gmd [H]

Synonym: gll0763

Alternate gene names: 37520332

Gene position: 817247-816198 (Counterclockwise)

Preceding gene: 37520333

Following gene: 37520331

Centisome position: 17.54

GC content: 62.48

Gene sequence:

>1050_bases
ATGAGCGAATCCAAGCGCGCCTTGATCACTGGGATCACCGGTCAGGACGGATCTTACCTGGCTGAATATCTGCTTGGCTG
CGGCTACGAAGTGCACGGTTTGCTGCGGCGCAGCAGCACCCTCAACGTCGGTCGGGTCTCGCACCTGCAGGAGCGCATCC
AGTTGCACTATTCGGATTTGACCGATTCGATGAGTTTGCAGCGTGTTCTGCAGCTGTGCGAACCGCACGAAGTCTACAAC
CTGGCCGCCCAGTCGCACGTCAAAGTTTCCTTCGACCAGCCCATCTACACCGGCGATGCGACGGCTCTCGGGGTGACCAG
ACTACTGGAAGCTGTGCGGATGATCGTGCCGGAGGCGCGCTTCTACCAGGCGTCTTCCTCCGAGATGTTCGGCAAAGTGC
GCGAGGTGCCCCAGACCGAATTGACCCCTTTCCATCCGCGCTCGCCCTACGCGGTGGCCAAAGTCTACGGCTATTGGGCG
ACGGTCAACTACCGCGAAGCCCACGGCCTGTTCGCCTGCAACGGCATCCTGTTCAACCACGAATCCCCAAGACGTGGAGA
GGATTTTGTAACGCGCAAGATCACCTGTGCGGTGGCGCGCATTGCGGCGGGCAAGCAGCGCGAACTGGTGCTGGGCAATA
CCGAAGCGCGGCGCGACTGGGGCTACGCGGGGGATTACGTCGAATTGATGTGGCGGATGCTCCAGCAGGAGAAGCCCGAC
GACTACGTGGTGGCCACCAACGAACAGTGGAGCGTGCAGCAATTTGTCGAGCGCGCCTTCGAATTAGTGGACCTCGACTG
GCGCCAGTACGTGCGCACCGACCCGCGCTACTTCCGCCCGGCGGAGGTGGACGAACTGATCGGCAACCCGGCTAAAGCCC
GCGAGCAGCTCGGCTGGCAGCCGCGGGTGCGCTTTGACGGATTGGTACGGCTGATGCTCGCGGCGGACCTGGTGGCCAAC
GGGGTGATGCCCGAGTTCGACTGGCCCGAAGTCGAAGATATCGGTCTGTACGCCGCGCCGGGTTTCAAGCTGCTGCGCCC
GGCCCGATAA

Upstream 100 bases:

>100_bases
TTTCAAGCGCTGGTGCGATTGATGGTAGACTCGGCCATTGAACAGGTGAAGGCCGCCACCTTGAGTGCCGCCGCTTCCAG
AGAACACTGACAGGAGAAAC

Downstream 100 bases:

>100_bases
TCGCGCCACCCGGCTGTGGCACACTGTGGGCATGGGGTTATCCATCCACAGTCTCAGAAAGCTCAAAGAGCGCGCCCAAC
CGATTGTCGCCCTTACCGCC

Product: GDP-D-mannose dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSESKRALITGITGQDGSYLAEYLLGCGYEVHGLLRRSSTLNVGRVSHLQERIQLHYSDLTDSMSLQRVLQLCEPHEVYN
LAAQSHVKVSFDQPIYTGDATALGVTRLLEAVRMIVPEARFYQASSSEMFGKVREVPQTELTPFHPRSPYAVAKVYGYWA
TVNYREAHGLFACNGILFNHESPRRGEDFVTRKITCAVARIAAGKQRELVLGNTEARRDWGYAGDYVELMWRMLQQEKPD
DYVVATNEQWSVQQFVERAFELVDLDWRQYVRTDPRYFRPAEVDELIGNPAKAREQLGWQPRVRFDGLVRLMLAADLVAN
GVMPEFDWPEVEDIGLYAAPGFKLLRPAR

Sequences:

>Translated_349_residues
MSESKRALITGITGQDGSYLAEYLLGCGYEVHGLLRRSSTLNVGRVSHLQERIQLHYSDLTDSMSLQRVLQLCEPHEVYN
LAAQSHVKVSFDQPIYTGDATALGVTRLLEAVRMIVPEARFYQASSSEMFGKVREVPQTELTPFHPRSPYAVAKVYGYWA
TVNYREAHGLFACNGILFNHESPRRGEDFVTRKITCAVARIAAGKQRELVLGNTEARRDWGYAGDYVELMWRMLQQEKPD
DYVVATNEQWSVQQFVERAFELVDLDWRQYVRTDPRYFRPAEVDELIGNPAKAREQLGWQPRVRFDGLVRLMLAADLVAN
GVMPEFDWPEVEDIGLYAAPGFKLLRPAR
>Mature_348_residues
SESKRALITGITGQDGSYLAEYLLGCGYEVHGLLRRSSTLNVGRVSHLQERIQLHYSDLTDSMSLQRVLQLCEPHEVYNL
AAQSHVKVSFDQPIYTGDATALGVTRLLEAVRMIVPEARFYQASSSEMFGKVREVPQTELTPFHPRSPYAVAKVYGYWAT
VNYREAHGLFACNGILFNHESPRRGEDFVTRKITCAVARIAAGKQRELVLGNTEARRDWGYAGDYVELMWRMLQQEKPDD
YVVATNEQWSVQQFVERAFELVDLDWRQYVRTDPRYFRPAEVDELIGNPAKAREQLGWQPRVRFDGLVRLMLAADLVANG
VMPEFDWPEVEDIGLYAAPGFKLLRPAR

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=338, Percent_Identity=52.9585798816568, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1788366, Length=352, Percent_Identity=54.2613636363636, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI48994969, Length=334, Percent_Identity=25.1497005988024, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788353, Length=345, Percent_Identity=22.8985507246377, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=342, Percent_Identity=55.2631578947368, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=53.6656891495601, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=53.6656891495601, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=53.6656891495601, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=53.6656891495601, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=53.6656891495601, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24158427, Length=343, Percent_Identity=54.2274052478134, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 39841; Mature: 39710

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESKRALITGITGQDGSYLAEYLLGCGYEVHGLLRRSSTLNVGRVSHLQERIQLHYSDL
CCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
TDSMSLQRVLQLCEPHEVYNLAAQSHVKVSFDQPIYTGDATALGVTRLLEAVRMIVPEAR
HHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCEECCCHHHHHHHHHHHHHHHHCCHHH
FYQASSSEMFGKVREVPQTELTPFHPRSPYAVAKVYGYWATVNYREAHGLFACNGILFNH
HHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEHHEEEEEHHHCCEEEECCEEECC
ESPRRGEDFVTRKITCAVARIAAGKQRELVLGNTEARRDWGYAGDYVELMWRMLQQEKPD
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCC
DYVVATNEQWSVQQFVERAFELVDLDWRQYVRTDPRYFRPAEVDELIGNPAKAREQLGWQ
CEEEECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHCCCC
PRVRFDGLVRLMLAADLVANGVMPEFDWPEVEDIGLYAAPGFKLLRPAR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCEEECCCHHHCCCCC
>Mature Secondary Structure 
SESKRALITGITGQDGSYLAEYLLGCGYEVHGLLRRSSTLNVGRVSHLQERIQLHYSDL
CCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
TDSMSLQRVLQLCEPHEVYNLAAQSHVKVSFDQPIYTGDATALGVTRLLEAVRMIVPEAR
HHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCEECCCHHHHHHHHHHHHHHHHCCHHH
FYQASSSEMFGKVREVPQTELTPFHPRSPYAVAKVYGYWATVNYREAHGLFACNGILFNH
HHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEHHEEEEEHHHCCEEEECCEEECC
ESPRRGEDFVTRKITCAVARIAAGKQRELVLGNTEARRDWGYAGDYVELMWRMLQQEKPD
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCC
DYVVATNEQWSVQQFVERAFELVDLDWRQYVRTDPRYFRPAEVDELIGNPAKAREQLGWQ
CEEEECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHCCCC
PRVRFDGLVRLMLAADLVANGVMPEFDWPEVEDIGLYAAPGFKLLRPAR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCEEECCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]