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The map label for this gene is proC [H]

Identifier: 37520273

GI number: 37520273

Start: 749838

End: 750629

Strand: Direct

Name: proC [H]

Synonym: glr0704

Alternate gene names: 37520273

Gene position: 749838-750629 (Clockwise)

Preceding gene: 37520272

Following gene: 37520275

Centisome position: 16.09

GC content: 70.08

Gene sequence:

>792_bases
ATGAACTTAGGCATTGTCGGCGGCGGTGCGATGGCCGAGGCTTTGATCGCCGGCCTGATCGCCGGCGCGGTTTATGCACC
TTCGGAAATTGCCGTGAGCGACCCGGTGGCCGAGCGCGGCGAGTGGCTCCATCGCCGCTACGGCGTGGTGGCCGTCACCG
ACAATCTGGTTCCCGCCGCTGCCCCGACGCTGCTTTTGGCTGTCAAGCCCCAGGCTTTTGCCGTGGTGAGCAACCAGGTT
GCCGCCCATGTGCGCTCCGAACTGGTGGTGTCGATCCTGGCGGGCGTTCCGCTGGCCCGCCTGCAGGCGGCCTTTACCGG
GCGGGCTGTCGTGCGGGCGATGCCCAACACCCCGGCGCTGGTGCGCTCCGGAATCACTGCCCTCAGCCGCTCGGAGCGCG
TCACCCCGGAGCAGTTTGCCGTCGCGCGCACGCTCTTCGCCTGCGTGGGTGAAGTGGTCGAGGTGCCCGAATCCGCCATG
GACGCGGTGACGGGCTTGTCGGGCTCCGGTCCCGGTTATCTGGCGCTCGTGGTCGAGGCGCTCATCGACGGCGGCGTGGC
CGCCGGTCTGCCGCGGGCCACCGCCAGCCAGCTGGTGCTTGCCACCTTGCGCGGCAGCGCGGAGTTGTTGATCCAGGAGA
AGCTGCACCCGGCGGTGCTCAAAGACCGCGTCACCAGCCCCGGCGGCACCACCATCGCCGGCATCGAGCAACTGGAGGGA
CGCTCGGTGCGCGGGGCGTTTATCGAGGCGGTCCAGGCCGCCACCCGCCGCGCCCGGGAACTGTCCGGGTAG

Upstream 100 bases:

>100_bases
TCAGGCCAACCAGGCCTTCGGCGGCAACTTCCGGCTCAACCCGGAAGCCCCCCGCCGCGCCCAGGGCTAGAATAAGCGGG
CACTCGCGTCCCCCTTGCCC

Downstream 100 bases:

>100_bases
CGGCTAGTTGGGTTCCGTCGGCACCGGTCCCTGTTCGAGCCAGAGCGAGCGCCGGTCGTAATCGATAGTCAGGCGGTAAT
GTTTCAAGAATGTGTAACCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAAAPTLLLAVKPQAFAVVSNQV
AAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPALVRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAM
DAVTGLSGSGPGYLALVVEALIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEG
RSVRGAFIEAVQAATRRARELSG

Sequences:

>Translated_263_residues
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAAAPTLLLAVKPQAFAVVSNQV
AAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPALVRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAM
DAVTGLSGSGPGYLALVVEALIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEG
RSVRGAFIEAVQAATRRARELSG
>Mature_263_residues
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAAAPTLLLAVKPQAFAVVSNQV
AAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPALVRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAM
DAVTGLSGSGPGYLALVVEALIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEG
RSVRGAFIEAVQAATRRARELSG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=36.9402985074627, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=36.9402985074627, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=37.3134328358209, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=36.1216730038023, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=37.5, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=39.2452830188679, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17540664, Length=276, Percent_Identity=31.5217391304348, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=32.280701754386, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648116, Length=273, Percent_Identity=36.996336996337, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.8490566037736, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=40.5882352941176, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26891; Mature: 26891

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAA
CCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCC
APTLLLAVKPQAFAVVSNQVAAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPAL
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHH
VRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAMDAVTGLSGSGPGYLALVVEA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHH
LIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEG
HHCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHCC
RSVRGAFIEAVQAATRRARELSG
CCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLGIVGGGAMAEALIAGLIAGAVYAPSEIAVSDPVAERGEWLHRRYGVVAVTDNLVPAA
CCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCC
APTLLLAVKPQAFAVVSNQVAAHVRSELVVSILAGVPLARLQAAFTGRAVVRAMPNTPAL
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHH
VRSGITALSRSERVTPEQFAVARTLFACVGEVVEVPESAMDAVTGLSGSGPGYLALVVEA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHH
LIDGGVAAGLPRATASQLVLATLRGSAELLIQEKLHPAVLKDRVTSPGGTTIAGIEQLEG
HHCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHCC
RSVRGAFIEAVQAATRRARELSG
CCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]