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The map label for this gene is dxs

Identifier: 37519763

GI number: 37519763

Start: 182701

End: 184617

Strand: Reverse

Name: dxs

Synonym: gll0194

Alternate gene names: 37519763

Gene position: 184617-182701 (Counterclockwise)

Preceding gene: 37519764

Following gene: 37519761

Centisome position: 3.96

GC content: 63.64

Gene sequence:

>1917_bases
ATGAATCTGAGCGATCTTTCCCACCCGAACCAGCTGCGCGATCTTTCTGTCTCTCAACTCGGCCGACTGGCCCAGCAAAT
TCGCGACAAGCACCTGCAGACGGTGGCGGCGACGGGTGGTCACCTCGGCCCCGGCCTGGGGGTGGTCGAATTGACCCTGG
CTCTCTACAAGACGCTCGATCTCGACCGCGACCGGGTGGTATGGGACGTGGGCCACCAGGCTTACCCCCATAAGATGCTC
ACCGGGCGCTACGCGAACTTTCATACCCTGCGCCAAAAAGACGGCCTCGCCGGCTACCTCAAGCGCGCCGAGAGCCCCTT
CGACTGCTGGGGGGCGGGTCACGCCTCCACGAGCATCTCAGCAGCTTTGGGAATGGCCCTGGCGCGGGACTTCCAGGGGC
TCAACCGCAAAGTCGTGGCGATCATCGGCGACGGGGCGCTCACCGGCGGCATGGCCCTCGAAGCTCTCAACCACGCCGGG
CATCTGAGCAAGACCAACCTGATGGTTATCCTCAACGACAACGAAATGTCCATTTCCGAAAACGTCGGGGGGCTGTCGCT
CTATCTCAACCGGCTGCGCACCGACCCGGCCCTGCGCCAGATCCGCAGCAACCTCGAGACGCAACTGCGCAACATTCCGC
TGGTCGGTCCCACGTTCAGCCCCGAATTCGAGCGCTTCAAAGACACCGTCAAGTACATGACCATGACCCGCTCGAAGGCG
GGGGTCATCTTCGAAGAACTGGGCTTTACCTACCTGGGTCCCATCGACGGCCACAACCTGGGCGATTTGATCGAAACCTT
TGAATTTGCCCATTCGCTGCCGGGGCCGGTCTTCTTGCACGCGATCACCGTCAAGGGCAAGGGCTACGAGGTGGCCGAGC
AAAACCAGATCAAGTACCACGCCCAGAGTGCTTTTGATCTGGCCACCGGCAAGGCCAAACCGGCCAGCAAACCGACCCCG
CCCGCCTACACATCGGTTTTCGCCCAGACCCTGGTAAAACTTGCCGAGCAAAACGAAAAGATTGTGGGCATCACCGCCGC
GATGCCCACCGGCACCGGTCTCGACAAATTCAAAGAGCGCTTTGCCGATCGTTACTTCGATGTGGGCATTGCCGAGCAGC
ACGCCGTGACGATGGCGGCCGGCCTGGCTGCCGACGGGATGCGTCCGGTGGCGGCCATCTACTCGACGTTCCTGCAGCGC
GCCTTCGATCAGATCATCCACGACGTGGCGATTCAGGATCTGCCGGTCTTCTTCTGCCTCGACCGCGCCGGAGTGGTGGG
CGAGGACGGCCCCACCCACCACGGCGTCTTCGACCTGGCCTACCTGCGCCAGATTCCTGGTCTGGTGGTGATGGCCCCCA
AGGACGAGGCCGAATTGCAGCGGATGATGGTGACCGGCATTCAGTACACCAAGGGCCCGATCGCCGTGCGCTACCCACGC
GGATCGGGCTCCGGCGCGCCGTTGATGGCCGAGGGCTGGGATCCGGTACCGATAGGTAAAGCCGAGGTGCTGCGCAGCGG
CGACGACTTGCTCATCGTGGCTATCGGCACGATGGTTCACCCGTCGCTGCAGGCGGCGGCGCTGCTGAGCGAACACGGCA
TCGACGCGACGGTGGTCAACGCCCGCTTCGCCAAGCCCCTCGACACCGAATTGCTGTTGCCTTTGGCCCGCCGCATCGGC
CGGGTGGTAACGGTCGAAGAAGGCTGCCGCATGGGCGGCTTCGGCTCGGCGGTGCTCGAAGCGCTCATGGACGGCGGGAT
TGCCGTGCCGACCCTCAGAATCGGCATCGACGACAAATTTGTCACCCACGCCGGCCGCTCGCAACTCCTCGACCTGCTGG
GATTGACCCCGAGCGGCATTGCCAAAACGATCCGCGAAAGCCTGTCCACCGAACCGGTAAGCGCCCCGCGCGCCTGA

Upstream 100 bases:

>100_bases
GGTAAGCGGTAATACTTACCCGGGCAACGGCCAATTCGGGCGCTTTGCGCGCGTCGGTGCACATTTCGTTATATTTGATG
GGAGCACAGCAGAGCAAAGC

Downstream 100 bases:

>100_bases
GCAAGCTCCCCTGCGACTGAGCGCCATCGGCGAGCGTCTGGCGGCCCAGCCCGGCTGAAGAGCTGACAGAAGGGCACTGT
CTGATTTCAACCGTGCCGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MNLSDLSHPNQLRDLSVSQLGRLAQQIRDKHLQTVAATGGHLGPGLGVVELTLALYKTLDLDRDRVVWDVGHQAYPHKML
TGRYANFHTLRQKDGLAGYLKRAESPFDCWGAGHASTSISAALGMALARDFQGLNRKVVAIIGDGALTGGMALEALNHAG
HLSKTNLMVILNDNEMSISENVGGLSLYLNRLRTDPALRQIRSNLETQLRNIPLVGPTFSPEFERFKDTVKYMTMTRSKA
GVIFEELGFTYLGPIDGHNLGDLIETFEFAHSLPGPVFLHAITVKGKGYEVAEQNQIKYHAQSAFDLATGKAKPASKPTP
PAYTSVFAQTLVKLAEQNEKIVGITAAMPTGTGLDKFKERFADRYFDVGIAEQHAVTMAAGLAADGMRPVAAIYSTFLQR
AFDQIIHDVAIQDLPVFFCLDRAGVVGEDGPTHHGVFDLAYLRQIPGLVVMAPKDEAELQRMMVTGIQYTKGPIAVRYPR
GSGSGAPLMAEGWDPVPIGKAEVLRSGDDLLIVAIGTMVHPSLQAAALLSEHGIDATVVNARFAKPLDTELLLPLARRIG
RVVTVEEGCRMGGFGSAVLEALMDGGIAVPTLRIGIDDKFVTHAGRSQLLDLLGLTPSGIAKTIRESLSTEPVSAPRA

Sequences:

>Translated_638_residues
MNLSDLSHPNQLRDLSVSQLGRLAQQIRDKHLQTVAATGGHLGPGLGVVELTLALYKTLDLDRDRVVWDVGHQAYPHKML
TGRYANFHTLRQKDGLAGYLKRAESPFDCWGAGHASTSISAALGMALARDFQGLNRKVVAIIGDGALTGGMALEALNHAG
HLSKTNLMVILNDNEMSISENVGGLSLYLNRLRTDPALRQIRSNLETQLRNIPLVGPTFSPEFERFKDTVKYMTMTRSKA
GVIFEELGFTYLGPIDGHNLGDLIETFEFAHSLPGPVFLHAITVKGKGYEVAEQNQIKYHAQSAFDLATGKAKPASKPTP
PAYTSVFAQTLVKLAEQNEKIVGITAAMPTGTGLDKFKERFADRYFDVGIAEQHAVTMAAGLAADGMRPVAAIYSTFLQR
AFDQIIHDVAIQDLPVFFCLDRAGVVGEDGPTHHGVFDLAYLRQIPGLVVMAPKDEAELQRMMVTGIQYTKGPIAVRYPR
GSGSGAPLMAEGWDPVPIGKAEVLRSGDDLLIVAIGTMVHPSLQAAALLSEHGIDATVVNARFAKPLDTELLLPLARRIG
RVVTVEEGCRMGGFGSAVLEALMDGGIAVPTLRIGIDDKFVTHAGRSQLLDLLGLTPSGIAKTIRESLSTEPVSAPRA
>Mature_638_residues
MNLSDLSHPNQLRDLSVSQLGRLAQQIRDKHLQTVAATGGHLGPGLGVVELTLALYKTLDLDRDRVVWDVGHQAYPHKML
TGRYANFHTLRQKDGLAGYLKRAESPFDCWGAGHASTSISAALGMALARDFQGLNRKVVAIIGDGALTGGMALEALNHAG
HLSKTNLMVILNDNEMSISENVGGLSLYLNRLRTDPALRQIRSNLETQLRNIPLVGPTFSPEFERFKDTVKYMTMTRSKA
GVIFEELGFTYLGPIDGHNLGDLIETFEFAHSLPGPVFLHAITVKGKGYEVAEQNQIKYHAQSAFDLATGKAKPASKPTP
PAYTSVFAQTLVKLAEQNEKIVGITAAMPTGTGLDKFKERFADRYFDVGIAEQHAVTMAAGLAADGMRPVAAIYSTFLQR
AFDQIIHDVAIQDLPVFFCLDRAGVVGEDGPTHHGVFDLAYLRQIPGLVVMAPKDEAELQRMMVTGIQYTKGPIAVRYPR
GSGSGAPLMAEGWDPVPIGKAEVLRSGDDLLIVAIGTMVHPSLQAAALLSEHGIDATVVNARFAKPLDTELLLPLARRIG
RVVTVEEGCRMGGFGSAVLEALMDGGIAVPTLRIGIDDKFVTHAGRSQLLDLLGLTPSGIAKTIRESLSTEPVSAPRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=689, Percent_Identity=26.4150943396226, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4507521, Length=689, Percent_Identity=26.4150943396226, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI133778974, Length=680, Percent_Identity=24.5588235294118, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637463, Length=303, Percent_Identity=29.3729372937294, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637459, Length=303, Percent_Identity=29.3729372937294, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637461, Length=303, Percent_Identity=29.3729372937294, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156564403, Length=261, Percent_Identity=27.2030651340996, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4557353, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI34101272, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI291084858, Length=253, Percent_Identity=27.6679841897233, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=46.1290322580645, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17539652, Length=426, Percent_Identity=30.2816901408451, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17538422, Length=311, Percent_Identity=26.3665594855305, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=295, Percent_Identity=26.7796610169492, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551847, Length=656, Percent_Identity=27.7439024390244, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI45550715, Length=656, Percent_Identity=27.7439024390244, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24645119, Length=612, Percent_Identity=27.9411764705882, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24666278, Length=671, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21358145, Length=258, Percent_Identity=29.4573643410853, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24650940, Length=258, Percent_Identity=29.4573643410853, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI160714832, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI160714828, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_GLOVI (Q7NP63)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923140.1
- ProteinModelPortal:   Q7NP63
- SMR:   Q7NP63
- GeneID:   2599979
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0194
- NMPDR:   fig|251221.1.peg.194
- HOGENOM:   HBG571647
- OMA:   VSNTGGH
- ProtClustDB:   PRK05444
- BioCyc:   GVIO251221:GLL0194-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68803; Mature: 68803

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSDLSHPNQLRDLSVSQLGRLAQQIRDKHLQTVAATGGHLGPGLGVVELTLALYKTLD
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
LDRDRVVWDVGHQAYPHKMLTGRYANFHTLRQKDGLAGYLKRAESPFDCWGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHH
AALGMALARDFQGLNRKVVAIIGDGALTGGMALEALNHAGHLSKTNLMVILNDNEMSISE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEHHC
NVGGLSLYLNRLRTDPALRQIRSNLETQLRNIPLVGPTFSPEFERFKDTVKYMTMTRSKA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GVIFEELGFTYLGPIDGHNLGDLIETFEFAHSLPGPVFLHAITVKGKGYEVAEQNQIKYH
CHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEH
AQSAFDLATGKAKPASKPTPPAYTSVFAQTLVKLAEQNEKIVGITAAMPTGTGLDKFKER
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
FADRYFDVGIAEQHAVTMAAGLAADGMRPVAAIYSTFLQRAFDQIIHDVAIQDLPVFFCL
HHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DRAGVVGEDGPTHHGVFDLAYLRQIPGLVVMAPKDEAELQRMMVTGIQYTKGPIAVRYPR
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCEEEEECC
GSGSGAPLMAEGWDPVPIGKAEVLRSGDDLLIVAIGTMVHPSLQAAALLSEHGIDATVVN
CCCCCCCEEECCCCCCCCCHHHHHCCCCCEEEEEECHHHCCHHHHHHHHHHCCCCEEEEC
ARFAKPLDTELLLPLARRIGRVVTVEEGCRMGGFGSAVLEALMDGGIAVPTLRIGIDDKF
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHH
VTHAGRSQLLDLLGLTPSGIAKTIRESLSTEPVSAPRA
HHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNLSDLSHPNQLRDLSVSQLGRLAQQIRDKHLQTVAATGGHLGPGLGVVELTLALYKTLD
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
LDRDRVVWDVGHQAYPHKMLTGRYANFHTLRQKDGLAGYLKRAESPFDCWGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHH
AALGMALARDFQGLNRKVVAIIGDGALTGGMALEALNHAGHLSKTNLMVILNDNEMSISE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEHHC
NVGGLSLYLNRLRTDPALRQIRSNLETQLRNIPLVGPTFSPEFERFKDTVKYMTMTRSKA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GVIFEELGFTYLGPIDGHNLGDLIETFEFAHSLPGPVFLHAITVKGKGYEVAEQNQIKYH
CHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEH
AQSAFDLATGKAKPASKPTPPAYTSVFAQTLVKLAEQNEKIVGITAAMPTGTGLDKFKER
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
FADRYFDVGIAEQHAVTMAAGLAADGMRPVAAIYSTFLQRAFDQIIHDVAIQDLPVFFCL
HHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DRAGVVGEDGPTHHGVFDLAYLRQIPGLVVMAPKDEAELQRMMVTGIQYTKGPIAVRYPR
CCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCEEEEECC
GSGSGAPLMAEGWDPVPIGKAEVLRSGDDLLIVAIGTMVHPSLQAAALLSEHGIDATVVN
CCCCCCCEEECCCCCCCCCHHHHHCCCCCEEEEEECHHHCCHHHHHHHHHHCCCCEEEEC
ARFAKPLDTELLLPLARRIGRVVTVEEGCRMGGFGSAVLEALMDGGIAVPTLRIGIDDKF
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHH
VTHAGRSQLLDLLGLTPSGIAKTIRESLSTEPVSAPRA
HHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292