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The map label for this gene is nadA [H]

Identifier: 37519761

GI number: 37519761

Start: 180454

End: 181413

Strand: Reverse

Name: nadA [H]

Synonym: gvip016

Alternate gene names: 37519761

Gene position: 181413-180454 (Counterclockwise)

Preceding gene: 37519763

Following gene: 37519758

Centisome position: 3.89

GC content: 63.96

Gene sequence:

>960_bases
ATGCTTACCATCCAACGTCCCGCCATCGATCCCCGCCTGGATCTGTTTGCTGAGATCGAGCGGCTCAAGCGCGAGTTGAA
CGCGGTCATCCTGGCGCACTACTACCAAGATCCCGACATCCAGGATGTGGCCGACTACATCGGCGACTCGCTCGGCCTCT
CGCGCCAGGCCGCCGCCACCGACGCCCGGGTAATCGTCTTCGCGGGTGTGCACTTCATGGCCGAGACCGCCAAGATTCTC
AACCCCACCAAACAGGTGCTTCTGCCGGATCTGGCCGCCGGTTGCTCGCTTTCTGACAACTGCCCGTCCGACCGGTTCGC
CGAATTTCTGCGGGCCTACCCGGGCCACATCGTCATCTCCTATATCAACTGCTCGGCGGCGGTCAAGGCACTCAGCGACA
TCATCTGCACCTCGGCCAACGCCGTGGCCATCGTCAATCAGATCCCCAAAGACCAGCCGATTGTCTTTGCCCCCGACCGC
AACCTGGGCCGCTATGTGATGGCGCAGAGCGGGCGGGAGATGGTGCTGTGGCCGGGGACGTGCATCGTGCACGAGACTTT
TTCGGAGCGCAAGCTGATCGCCCTCAAGGTGCGCCACCCCGACGCCGAGGTGATCGCCCACCCCGAGTGCGAACCGGCGG
TGCTGCGCCACGCCGATTTTGTCGGTTCGACCACCGCTCTACTCAAGTACGCGGGCACCAGCGATAGGCGGGCCTTCATC
GTGGTCACCGAGGCGGGCATCTTGCACCAGATGCAAAAAGCCCACCCCGACAAACTGTTCATCCCAGCGCCGCCCGAGGC
CGATTGCGCCTGCAACGAGTGCCCGTTCATGCGCCTCAACACCCTTGAGAAGCTCTACCTGTGCATGCGCGACCGCACCC
CCGAGGTCACCCTCGACGAAGCCACCCGCCTGCGCGCCCTCACGCCCATCGAGCGGATGCTCGCGATGAGCCCGAAGTAA

Upstream 100 bases:

>100_bases
ACTCATAATACACAATGCCCATCCCAAAAGGGGGTTTAAGCATCCCTGGGGACTCACCCACCCAAAAAGTTAAACTGGAA
AGACAGCCCCAAGCCAAGCG

Downstream 100 bases:

>100_bases
CGCTCAACCGGTCCAGCGGCGCAAGATGTCCAGGTAACTGAGCGCCACCAGGGTATCTGACACTTCGAGTGCGTCGCGGG
CGCCAACGACGGCGTTCGCC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MLTIQRPAIDPRLDLFAEIERLKRELNAVILAHYYQDPDIQDVADYIGDSLGLSRQAAATDARVIVFAGVHFMAETAKIL
NPTKQVLLPDLAAGCSLSDNCPSDRFAEFLRAYPGHIVISYINCSAAVKALSDIICTSANAVAIVNQIPKDQPIVFAPDR
NLGRYVMAQSGREMVLWPGTCIVHETFSERKLIALKVRHPDAEVIAHPECEPAVLRHADFVGSTTALLKYAGTSDRRAFI
VVTEAGILHQMQKAHPDKLFIPAPPEADCACNECPFMRLNTLEKLYLCMRDRTPEVTLDEATRLRALTPIERMLAMSPK

Sequences:

>Translated_319_residues
MLTIQRPAIDPRLDLFAEIERLKRELNAVILAHYYQDPDIQDVADYIGDSLGLSRQAAATDARVIVFAGVHFMAETAKIL
NPTKQVLLPDLAAGCSLSDNCPSDRFAEFLRAYPGHIVISYINCSAAVKALSDIICTSANAVAIVNQIPKDQPIVFAPDR
NLGRYVMAQSGREMVLWPGTCIVHETFSERKLIALKVRHPDAEVIAHPECEPAVLRHADFVGSTTALLKYAGTSDRRAFI
VVTEAGILHQMQKAHPDKLFIPAPPEADCACNECPFMRLNTLEKLYLCMRDRTPEVTLDEATRLRALTPIERMLAMSPK
>Mature_319_residues
MLTIQRPAIDPRLDLFAEIERLKRELNAVILAHYYQDPDIQDVADYIGDSLGLSRQAAATDARVIVFAGVHFMAETAKIL
NPTKQVLLPDLAAGCSLSDNCPSDRFAEFLRAYPGHIVISYINCSAAVKALSDIICTSANAVAIVNQIPKDQPIVFAPDR
NLGRYVMAQSGREMVLWPGTCIVHETFSERKLIALKVRHPDAEVIAHPECEPAVLRHADFVGSTTALLKYAGTSDRRAFI
VVTEAGILHQMQKAHPDKLFIPAPPEADCACNECPFMRLNTLEKLYLCMRDRTPEVTLDEATRLRALTPIERMLAMSPK

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=318, Percent_Identity=42.1383647798742, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 35348; Mature: 35348

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIQRPAIDPRLDLFAEIERLKRELNAVILAHYYQDPDIQDVADYIGDSLGLSRQAAAT
CCEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHCC
DARVIVFAGVHFMAETAKILNPTKQVLLPDLAAGCSLSDNCPSDRFAEFLRAYPGHIVIS
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEE
YINCSAAVKALSDIICTSANAVAIVNQIPKDQPIVFAPDRNLGRYVMAQSGREMVLWPGT
EECHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCEEECCCCCCCHHHHHCCCCEEEEECCE
CIVHETFSERKLIALKVRHPDAEVIAHPECEPAVLRHADFVGSTTALLKYAGTSDRRAFI
EEEECCCCCCEEEEEEEECCCHHEEECCCCCHHHHHHHHHCCCHHHHHEECCCCCCEEEE
VVTEAGILHQMQKAHPDKLFIPAPPEADCACNECPFMRLNTLEKLYLCMRDRTPEVTLDE
EEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHH
ATRLRALTPIERMLAMSPK
HHHHHHHCHHHHHHHCCCC
>Mature Secondary Structure
MLTIQRPAIDPRLDLFAEIERLKRELNAVILAHYYQDPDIQDVADYIGDSLGLSRQAAAT
CCEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHCC
DARVIVFAGVHFMAETAKILNPTKQVLLPDLAAGCSLSDNCPSDRFAEFLRAYPGHIVIS
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEE
YINCSAAVKALSDIICTSANAVAIVNQIPKDQPIVFAPDRNLGRYVMAQSGREMVLWPGT
EECHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCEEECCCCCCCHHHHHCCCCEEEEECCE
CIVHETFSERKLIALKVRHPDAEVIAHPECEPAVLRHADFVGSTTALLKYAGTSDRRAFI
EEEECCCCCCEEEEEEEECCCHHEEECCCCCHHHHHHHHHCCCHHHHHEECCCCCCEEEE
VVTEAGILHQMQKAHPDKLFIPAPPEADCACNECPFMRLNTLEKLYLCMRDRTPEVTLDE
EEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHH
ATRLRALTPIERMLAMSPK
HHHHHHHCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]