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The map label for this gene is mtnA

Identifier: 37519764

GI number: 37519764

Start: 184746

End: 185792

Strand: Reverse

Name: mtnA

Synonym: gll0195

Alternate gene names: 37519764

Gene position: 185792-184746 (Counterclockwise)

Preceding gene: 37519766

Following gene: 37519763

Centisome position: 3.99

GC content: 68.96

Gene sequence:

>1047_bases
ATGACTTTTAGCGCCGTCCAGTCCGAAATCCGGCCCGTGCAGTGGAATGGGCACACCTGCGTGCTCATCGATCAAACGGT
CCTGCCAGGGATCTACCGCACCATCGAAATTCGCACCAGCGATCAGATGGCCACCGCCATCCGCACGATGATCGTGCGCG
GGGCGCCCGCCATCGGGGTGGCCGCCGCCTTCGGCATGGTGCTGGGTTGGCAAGAAGCACCCCAGGGCGATCCGATCACC
CACCTGGAGCGGGTGGCCGCCACCCTGCGCGCCACCCGGCCCACCGCCGTCAATTTGTTCTGGGCTATCGACCGGATGCT
CACCGTCGCACGCCGGGATCCGAGCTTCGCGCGCCTGGAGCGCGAGGCGACGGCCATCCTCGAAGGGGACATCGCCACCT
GCCGCGCCATCGGTGAGCACGGCCTTCTGGCCCTGCCCGCCGCCCCCGAGCGGTTGCGCCTGCTCACCCACTGCAACGCC
GGAGCGCTCGCCACCGCCGGTTACGGCACCGCCCTCGGGGTGGTGCGCTCCGCCCACCGCGCCGACAGACTCGAGCGCGT
CTATGCCGACGAGACCCGTCCGCGCCTGCAGGGGGCGCGCCTCACCGCCTGGGAACTGGTGCACGAGCGCATCCCGGTCA
CGGTCCTGGCCGACACGATGGCCGCCCACGTCATCGGCCGGGGGCTGGTGGACGCGGTGGTGGTGGGGGCCGACCGGATC
GCCGCCAACGGCGACACCGCCAACAAGATCGGCACTTGCGGCGTGGCGATTATCGCCAGGCACTACGGTGTGCCCTTCTT
TGTAGCCGCCCCCTGGTCGACGGTGGACTTGAATCTGTCGAGCGGAGAACAGATCCCGATCGAACAGCGCGACAGCGAAG
AGATGCGCGCCATCGAAGGCGTGGCCCTCTGCCCGCAGGGCGTCGAATTTTATAATCCCGCCTTCGACGTCACCCCGGCC
TCTCTCGTCACCGGGATCATCGTCGAGAGCGGCGTCTACGCACCCGGCGAACTCGCGGCGGCCGGACAGGTCCGACTTGG
GCGCTAG

Upstream 100 bases:

>100_bases
TAGATTGCACCGGATTGGCCAGCCCACCGGTTTCGACCGAACTGGCATCGCGCACAAGGCTGGTGGCTCCGGGCACCGAT
GCTCTTGGTATTATCGACCC

Downstream 100 bases:

>100_bases
GGGGCAGTGCCCTGGACTTTCCGCGGCGGGTAAGCGGTAATACTTACCCGGGCAACGGCCAATTCGGGCGCTTTGCGCGC
GTCGGTGCACATTTCGTTAT

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGVAAAFGMVLGWQEAPQGDPIT
HLERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLEREATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNA
GALATAGYGTALGVVRSAHRADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRI
AANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEGVALCPQGVEFYNPAFDVTPA
SLVTGIIVESGVYAPGELAAAGQVRLGR

Sequences:

>Translated_348_residues
MTFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGVAAAFGMVLGWQEAPQGDPIT
HLERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLEREATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNA
GALATAGYGTALGVVRSAHRADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRI
AANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEGVALCPQGVEFYNPAFDVTPA
SLVTGIIVESGVYAPGELAAAGQVRLGR
>Mature_347_residues
TFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGVAAAFGMVLGWQEAPQGDPITH
LERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLEREATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNAG
ALATAGYGTALGVVRSAHRADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRIA
ANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEGVALCPQGVEFYNPAFDVTPAS
LVTGIIVESGVYAPGELAAAGQVRLGR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=350, Percent_Identity=42.8571428571429, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI23943880, Length=339, Percent_Identity=38.3480825958702, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4503503, Length=262, Percent_Identity=28.2442748091603, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17557462, Length=336, Percent_Identity=36.3095238095238, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17557123, Length=186, Percent_Identity=27.9569892473118, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=391, Percent_Identity=32.4808184143223, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21357667, Length=355, Percent_Identity=41.9718309859155, Blast_Score=260, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24651647, Length=355, Percent_Identity=41.9718309859155, Blast_Score=260, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_GLOVI (Q7NP62)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923141.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q7NP62
- SMR:   Q7NP62
- GeneID:   2599980
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0195
- NMPDR:   fig|251221.1.peg.195
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- BioCyc:   GVIO251221:GLL0195-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37236; Mature: 37105

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 238-238 BINDING 93-93 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGV
CCHHHHHHHCCCEEECCCEEEEECCHHCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHH
AAAFGMVLGWQEAPQGDPITHLERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
REATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNAGALATAGYGTALGVVRSAHR
HHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHH
ADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRI
HHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEG
ECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHC
VALCPQGVEFYNPAFDVTPASLVTGIIVESGVYAPGELAAAGQVRLGR
CEECCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
TFSAVQSEIRPVQWNGHTCVLIDQTVLPGIYRTIEIRTSDQMATAIRTMIVRGAPAIGV
CHHHHHHHCCCEEECCCEEEEECCHHCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHH
AAAFGMVLGWQEAPQGDPITHLERVAATLRATRPTAVNLFWAIDRMLTVARRDPSFARLE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
REATAILEGDIATCRAIGEHGLLALPAAPERLRLLTHCNAGALATAGYGTALGVVRSAHR
HHHHHHHCCCHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHH
ADRLERVYADETRPRLQGARLTAWELVHERIPVTVLADTMAAHVIGRGLVDAVVVGADRI
HHHHHHHHHCCCCHHHCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AANGDTANKIGTCGVAIIARHYGVPFFVAAPWSTVDLNLSSGEQIPIEQRDSEEMRAIEG
ECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHC
VALCPQGVEFYNPAFDVTPASLVTGIIVESGVYAPGELAAAGQVRLGR
CEECCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292