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The map label for this gene is yhdN [H]

Identifier: 37519758

GI number: 37519758

Start: 177871

End: 178851

Strand: Reverse

Name: yhdN [H]

Synonym: gll0189

Alternate gene names: 37519758

Gene position: 178851-177871 (Counterclockwise)

Preceding gene: 37519761

Following gene: 37519757

Centisome position: 3.84

GC content: 66.87

Gene sequence:

>981_bases
ATGGAACAGCGGCAATTGGGCAAAGGGGGACCGCGCGTATCAGCCCTCGGCCTCGGGTGCATGGGGATGTCGGATTTTTA
CGGCAAAGCCGACGAACAGGAGAGCATCGCCACAGTCCACCAGGCCCTCGACGCGGGGATCACCCTGTTCAACACCGGCG
ATTTTTACGGCATGGGGCACAACGAAATGTTGTTGCGCGAGGCGCTTGCAGACCGACGCGAGCAGGTGTTTCTCTCGGTC
AAATTTGGTGCCCAGCGCGCCCCGGATGGGACGTTTCTCGGTTTTGACGCCCGCCCGGCGGCGGTGAAGACGGCTCTCGC
CTACACCCTGCGCCGGCTGGGGACGGACCATGTCGATCTCTACCAGCCCGCGCGCATCGACCCGGCCGTGCCCATCGAGG
AGACAGTCGGCGCCATCGCCGAAATGGTCCAGGCAGGCTACGTCCGCTACATCGGCCTGTCGGAGGCGTCCGCTGCCACA
GTGCGCCGTGCCCACGCCGTCCATCCGATTGCGGCGCTGGAGATCGAGTACTCGCTGCTCACCCGCGACATCGAAGCTGA
GGTGCTTCCGACCGTGCGCGCACTGGGCATCGGGCTGGTGGCCTACGGGGTGCTCTCGCGGGGGTTACTGAGCGATCGGG
CCACCGGCACGTTCGCGGCGGACGATTTTCGGGCGCACCTGCCGCGCTTTGCGGGGGAAAATCTGCAGAACAACCTCGCC
CTGGTCGAAGCGCTGCGGGCGCTGGCGGCCGAAAAAGGCGTGGGGGTGGCACAGCTGGCGATCGCCTGGGTACTGGCGCG
CGGCGAGGACATCGTACCTCTGGTAGGCGCGCGGCGGCCCGCCCGGCTGAGCGAAGCCCTGGCTGCCGCTCAGGTGCATT
TGAGCGCCGAGGATATGGCGCGCATCGAGGCGGCTGTGCCCACCGCCGCTGTGGCCGGGACGCGCTACAGTACGGATCAA
ATGGCCATGCTGGACAGCTGA

Upstream 100 bases:

>100_bases
CCCGTCGCCCAGAAACCGCAAATGACAAATGACAGATATTGAAATTTGTCATAGCCTGTGAGAACCTGGGCGTATAGCCA
TCTATTTCAGGATACGAGCC

Downstream 100 bases:

>100_bases
GCACCGGATAAGCTTCCGGCAGTGTCCACTGGGCCGCAGCCGCCACTGCAGTGTCCGACACCACCCGCTCCCGCATTCTC
GAAGCCGCCGAACTGCTCCT

Product: oxidoreductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MEQRQLGKGGPRVSALGLGCMGMSDFYGKADEQESIATVHQALDAGITLFNTGDFYGMGHNEMLLREALADRREQVFLSV
KFGAQRAPDGTFLGFDARPAAVKTALAYTLRRLGTDHVDLYQPARIDPAVPIEETVGAIAEMVQAGYVRYIGLSEASAAT
VRRAHAVHPIAALEIEYSLLTRDIEAEVLPTVRALGIGLVAYGVLSRGLLSDRATGTFAADDFRAHLPRFAGENLQNNLA
LVEALRALAAEKGVGVAQLAIAWVLARGEDIVPLVGARRPARLSEALAAAQVHLSAEDMARIEAAVPTAAVAGTRYSTDQ
MAMLDS

Sequences:

>Translated_326_residues
MEQRQLGKGGPRVSALGLGCMGMSDFYGKADEQESIATVHQALDAGITLFNTGDFYGMGHNEMLLREALADRREQVFLSV
KFGAQRAPDGTFLGFDARPAAVKTALAYTLRRLGTDHVDLYQPARIDPAVPIEETVGAIAEMVQAGYVRYIGLSEASAAT
VRRAHAVHPIAALEIEYSLLTRDIEAEVLPTVRALGIGLVAYGVLSRGLLSDRATGTFAADDFRAHLPRFAGENLQNNLA
LVEALRALAAEKGVGVAQLAIAWVLARGEDIVPLVGARRPARLSEALAAAQVHLSAEDMARIEAAVPTAAVAGTRYSTDQ
MAMLDS
>Mature_326_residues
MEQRQLGKGGPRVSALGLGCMGMSDFYGKADEQESIATVHQALDAGITLFNTGDFYGMGHNEMLLREALADRREQVFLSV
KFGAQRAPDGTFLGFDARPAAVKTALAYTLRRLGTDHVDLYQPARIDPAVPIEETVGAIAEMVQAGYVRYIGLSEASAAT
VRRAHAVHPIAALEIEYSLLTRDIEAEVLPTVRALGIGLVAYGVLSRGLLSDRATGTFAADDFRAHLPRFAGENLQNNLA
LVEALRALAAEKGVGVAQLAIAWVLARGEDIVPLVGARRPARLSEALAAAQVHLSAEDMARIEAAVPTAAVAGTRYSTDQ
MAMLDS

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=310, Percent_Identity=28.7096774193548, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4504825, Length=307, Percent_Identity=28.6644951140065, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI27436964, Length=316, Percent_Identity=29.1139240506329, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27436966, Length=316, Percent_Identity=29.1139240506329, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27436962, Length=317, Percent_Identity=29.0220820189274, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436971, Length=312, Percent_Identity=30.1282051282051, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223718702, Length=316, Percent_Identity=27.8481012658228, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI41327764, Length=273, Percent_Identity=27.8388278388278, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI41152114, Length=317, Percent_Identity=25.2365930599369, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081735, Length=337, Percent_Identity=30.8605341246291, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=30.0319488817891, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789375, Length=342, Percent_Identity=28.6549707602339, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787674, Length=317, Percent_Identity=28.391167192429, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789199, Length=351, Percent_Identity=28.7749287749288, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788081, Length=316, Percent_Identity=24.6835443037975, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325169, Length=342, Percent_Identity=28.6549707602339, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323998, Length=323, Percent_Identity=25.6965944272446, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325384, Length=301, Percent_Identity=27.906976744186, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319958, Length=301, Percent_Identity=23.5880398671096, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322615, Length=254, Percent_Identity=26.3779527559055, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319951, Length=321, Percent_Identity=23.6760124610592, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646159, Length=227, Percent_Identity=32.15859030837, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646155, Length=276, Percent_Identity=27.1739130434783, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640980, Length=353, Percent_Identity=24.929178470255, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45549126, Length=353, Percent_Identity=24.929178470255, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34739; Mature: 34739

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQRQLGKGGPRVSALGLGCMGMSDFYGKADEQESIATVHQALDAGITLFNTGDFYGMGH
CCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCEECCCC
NEMLLREALADRREQVFLSVKFGAQRAPDGTFLGFDARPAAVKTALAYTLRRLGTDHVDL
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCC
YQPARIDPAVPIEETVGAIAEMVQAGYVRYIGLSEASAATVRRAHAVHPIAALEIEYSLL
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCHHEEEHHHHH
TRDIEAEVLPTVRALGIGLVAYGVLSRGLLSDRATGTFAADDFRAHLPRFAGENLQNNLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHCCCCHHHHHH
LVEALRALAAEKGVGVAQLAIAWVLARGEDIVPLVGARRPARLSEALAAAQVHLSAEDMA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCHHHHH
RIEAAVPTAAVAGTRYSTDQMAMLDS
HHHHHCCHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MEQRQLGKGGPRVSALGLGCMGMSDFYGKADEQESIATVHQALDAGITLFNTGDFYGMGH
CCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCEECCCC
NEMLLREALADRREQVFLSVKFGAQRAPDGTFLGFDARPAAVKTALAYTLRRLGTDHVDL
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCC
YQPARIDPAVPIEETVGAIAEMVQAGYVRYIGLSEASAATVRRAHAVHPIAALEIEYSLL
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCHHEEEHHHHH
TRDIEAEVLPTVRALGIGLVAYGVLSRGLLSDRATGTFAADDFRAHLPRFAGENLQNNLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHCCCCHHHHHH
LVEALRALAAEKGVGVAQLAIAWVLARGEDIVPLVGARRPARLSEALAAAQVHLSAEDMA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCHHHHH
RIEAAVPTAAVAGTRYSTDQMAMLDS
HHHHHCCHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]