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The map label for this gene is cobW [H]

Identifier: 37519692

GI number: 37519692

Start: 119842

End: 120897

Strand: Reverse

Name: cobW [H]

Synonym: gvip013

Alternate gene names: 37519692

Gene position: 120897-119842 (Counterclockwise)

Preceding gene: 37519696

Following gene: 37519688

Centisome position: 2.59

GC content: 62.88

Gene sequence:

>1056_bases
ATGCAGAAAGTACCCGTCACGGTGATCACCGGCTTTTTGGGAAGCGGCAAAACGACCCTTATCCGCCACATCCTCACCCA
CAATCAGGGGCTGCGCATCGCCGTGCTGGTCAACGAGTTCGGCGAACTGGGCATCGACGGCGAACTGGTCAAAGCCTGCG
GCGGCTGCGGTGAGGAGGACATCATCGAATTGACCAACGGCTGCTTGTGCTGCACGGTGCAGGAAGAATTTTTACCCACG
ATGCAGAGGCTGATCGCCCGCCGCGATGAGATCGACCACATTTTGGTCGAAACTTCCGGCTTGGCGCTTCCGAAACCGCT
GGTGCAGGCGTTTCGCTGGCCCGAAATTCGCAATGGCGCGACGGTTGATGGGGTGGTGACGATTGTGGATGCCGCTTCCG
TCGCGCGGGGCGGCCTGTTCGAGCGCACGAGCGACGCCCCCGGCCACGGCGCAACGGAGGAAGAACTTGTTGAGCTGTTC
GAAGATCAACTGGCCTGCGCTGACCTGGTTCTGCTCAACAAGAGCGATCAGGTGGCACCGGCGGATCAACCGGCCGTCGA
AGCGCACCTGCGCGCTTTGCTGCCGGATTCGGTCAAGCTCATCGCCGCAAGCCACAGCCGGGTGGACCCGCGCACTTTAT
TGGGTCTGGGTCAGGCGGTCGAAGAGCAGATCGCCAAGCGCCCCAGCCACCACGACAGCGAAGCAGAACACGACCACGAC
GAAGACATCCGGGCGCTCAGCGTGCGGCTGGAAGGACCGCAAGATCCCGACCGGCTGGTGGCCGCACTGCAGCGGCTGGT
GCGCTCCGACGAAATCTACCGGGTCAAGGGCTTTGTCCATGCCGCCGGTAAACCCCTGCGCCTGGTGATCCAGGGGGTAG
GTCACCGCTTCGAGCGCTACTTCGACCGTCCCTGGGGCAAAGATGAAACCCGCCGCACCGATCTGGTGATCATCGGCAAA
GATCTGGAGGCGGAAACGATCGGGCGGGCACTGGCCGAGGGCGCTCTCACAGCTCCGCGGCCAGATGCCAGTGCGCTCCC
GAAAACTGCAACTTGA

Upstream 100 bases:

>100_bases
ATCGACCTGCGTCCCGGGAGCGATATCAGGCAGCCGGGCTACGGCTTACCCATCCAGGGCAGTCGGTGTACGATAACGAA
GCTCAATTACACAACCTGTC

Downstream 100 bases:

>100_bases
GTCCTGCAGGCAAGCTGGGCACCCCGCGCTGCAGCAGCAGGCCCCGCCCTTCGAGATTGAGCAGCTGCGAGCCGCGGAAA
TTGGTGGCGAGCGGTTCTTT

Product: cobalamin synthesis protein cobW-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MQKVPVTVITGFLGSGKTTLIRHILTHNQGLRIAVLVNEFGELGIDGELVKACGGCGEEDIIELTNGCLCCTVQEEFLPT
MQRLIARRDEIDHILVETSGLALPKPLVQAFRWPEIRNGATVDGVVTIVDAASVARGGLFERTSDAPGHGATEEELVELF
EDQLACADLVLLNKSDQVAPADQPAVEAHLRALLPDSVKLIAASHSRVDPRTLLGLGQAVEEQIAKRPSHHDSEAEHDHD
EDIRALSVRLEGPQDPDRLVAALQRLVRSDEIYRVKGFVHAAGKPLRLVIQGVGHRFERYFDRPWGKDETRRTDLVIIGK
DLEAETIGRALAEGALTAPRPDASALPKTAT

Sequences:

>Translated_351_residues
MQKVPVTVITGFLGSGKTTLIRHILTHNQGLRIAVLVNEFGELGIDGELVKACGGCGEEDIIELTNGCLCCTVQEEFLPT
MQRLIARRDEIDHILVETSGLALPKPLVQAFRWPEIRNGATVDGVVTIVDAASVARGGLFERTSDAPGHGATEEELVELF
EDQLACADLVLLNKSDQVAPADQPAVEAHLRALLPDSVKLIAASHSRVDPRTLLGLGQAVEEQIAKRPSHHDSEAEHDHD
EDIRALSVRLEGPQDPDRLVAALQRLVRSDEIYRVKGFVHAAGKPLRLVIQGVGHRFERYFDRPWGKDETRRTDLVIIGK
DLEAETIGRALAEGALTAPRPDASALPKTAT
>Mature_351_residues
MQKVPVTVITGFLGSGKTTLIRHILTHNQGLRIAVLVNEFGELGIDGELVKACGGCGEEDIIELTNGCLCCTVQEEFLPT
MQRLIARRDEIDHILVETSGLALPKPLVQAFRWPEIRNGATVDGVVTIVDAASVARGGLFERTSDAPGHGATEEELVELF
EDQLACADLVLLNKSDQVAPADQPAVEAHLRALLPDSVKLIAASHSRVDPRTLLGLGQAVEEQIAKRPSHHDSEAEHDHD
EDIRALSVRLEGPQDPDRLVAALQRLVRSDEIYRVKGFVHAAGKPLRLVIQGVGHRFERYFDRPWGKDETRRTDLVIIGK
DLEAETIGRALAEGALTAPRPDASALPKTAT

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=345, Percent_Identity=32.7536231884058, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI223941779, Length=344, Percent_Identity=32.8488372093023, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI33469141, Length=348, Percent_Identity=31.8965517241379, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI148727351, Length=348, Percent_Identity=31.8965517241379, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI146231952, Length=348, Percent_Identity=32.183908045977, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI223941776, Length=334, Percent_Identity=31.437125748503, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI119120938, Length=336, Percent_Identity=29.1666666666667, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI87082430, Length=342, Percent_Identity=31.8713450292398, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788499, Length=278, Percent_Identity=29.8561151079137, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=360, Percent_Identity=26.9444444444444, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38204; Mature: 38204

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVPVTVITGFLGSGKTTLIRHILTHNQGLRIAVLVNEFGELGIDGELVKACGGCGEED
CCCCCEEHEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCHHHHHHHCCCCCHH
IIELTNGCLCCTVQEEFLPTMQRLIARRDEIDHILVETSGLALPKPLVQAFRWPEIRNGA
HHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHCCCCCCCCC
TVDGVVTIVDAASVARGGLFERTSDAPGHGATEEELVELFEDQLACADLVLLNKSDQVAP
CCCHHHEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCC
ADQPAVEAHLRALLPDSVKLIAASHSRVDPRTLLGLGQAVEEQIAKRPSHHDSEAEHDHD
CCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDIRALSVRLEGPQDPDRLVAALQRLVRSDEIYRVKGFVHAAGKPLRLVIQGVGHRFERY
CCEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHH
FDRPWGKDETRRTDLVIIGKDLEAETIGRALAEGALTAPRPDASALPKTAT
HCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKVPVTVITGFLGSGKTTLIRHILTHNQGLRIAVLVNEFGELGIDGELVKACGGCGEED
CCCCCEEHEECCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCHHHHHHHCCCCCHH
IIELTNGCLCCTVQEEFLPTMQRLIARRDEIDHILVETSGLALPKPLVQAFRWPEIRNGA
HHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHCCCCCCCCC
TVDGVVTIVDAASVARGGLFERTSDAPGHGATEEELVELFEDQLACADLVLLNKSDQVAP
CCCHHHEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCC
ADQPAVEAHLRALLPDSVKLIAASHSRVDPRTLLGLGQAVEEQIAKRPSHHDSEAEHDHD
CCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDIRALSVRLEGPQDPDRLVAALQRLVRSDEIYRVKGFVHAAGKPLRLVIQGVGHRFERY
CCEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHH
FDRPWGKDETRRTDLVIIGKDLEAETIGRALAEGALTAPRPDASALPKTAT
HCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]